Tumour‐induced alterations in single‐nucleus transcriptome of atrophying muscles indicate enhanced protein degradation and reduced oxidative metabolism
Samet Agca,
Aylin Domaniku‐Waraich,
Sevval Nur Bilgic
et al.
Abstract:BackgroundTumour‐induced skeletal muscle wasting in the context of cancer cachexia is a condition with profound implications for patient survival. The loss of muscle mass is a significant clinical obstacle and is linked to reduced tolerance to chemotherapy and increased frailty. Understanding the molecular mechanisms driving muscle atrophy is crucial for the design of new therapeutics.MethodsLewis lung carcinoma tumours were utilized to induce cachexia and muscle atrophy in mice. Single‐nucleus libraries of th… Show more
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