Tumour-enhancing Activity of the Active Principles of Croton tiglium L.

Tumorigenicity of acridine orange.

“…a single application of A.O. followed by repeated application of a potent tumor-promoting agent, phorbol myristate acetate (Van Duuren and Orris, 1965); (b) a promoting agent, i.e. a single application of 7,12-dimethylbenz(a)anthracene (DMBA), followed by repeated application of the dye, and (c) as a skin carcinogen by repeated application of the dye only.…”

“…In earlier studies with a series of epoxides and related compounds, we have compared carcinogenicity and mutagenicity (Van Duuren et al, 1965). Using data obtained from our own work and the literature, we have also compared these two properties with tumor-initiating activity for a series of 18 diverse compounds (Van Duuren and Sivak, 1968).…”

“…Using data obtained from our own work and the literature, we have also compared these two properties with tumor-initiating activity for a series of 18 diverse compounds (Van Duuren and Sivak, 1968). No clearcut correlations could be drawn from such comparative lists.…”

“…Phorbol myristate acetate. The preparation of this material was described earlier (Van Duuren and Orris, 1965).…”

“…The relationship between the mode of action of carcinogens, mutagens and tumor-initiating agents is a problem of continuing interest (Trainin et al, 1964;Van Duuren and Sivak, 1968). Since little is known about the tumor-initiating and carcinogenic activity of acridine orange, it was of interest to examine these properties in mice and rats.…”