Tumour characteristics, treatment patterns and survival of patients aged 80 years or older with colorectal cancer

Abstract

This study showed a significant difference in tumour characteristics and treatment patterns in patients aged 80 and above. Even after adjustment for clinicopathological factors, the difference in survival persisted and age was considered a robust prognostic factor.

Octogenarian patients with colorectal cancer: Characterizing an emerging clinical entity.

“…In agreement with previous reports [5][6][7] , we found that octogenarians had clear predilection for right colon tumors. This finding might suggest a distinct pathogenesis of CRC among older patients, such as a higher rate of MMR deficiency or its phenotype, MSI-H tumors.…”

“…While some studies imply that elderly patients with CRC might have unique features [5][6][7] as well as worse outcome [7][8][9] , these findings are not consistent [1013] . Elderly patients are considerably underrepresented in clinical trials [14,15] .…”

“…As the median age at diagnosis of CRC is 68 [2] , similar to some recent studies [5,6,16] we chose a cut off of 80 years old in order to emphasize agerelated characteristics.…”

A comparative study of short-term outcomes of colorectal cancer surgery in the elderly population

“…Likewise, this study observed similar, albeit higher, rates at 92.6% in <75 age group and 87.1% in the ≥75 age group, p=4.04. However, unlike kotake et al, no difference was found in LN yield between the two groups of patients (22).…”

“…Hence, lower PS score, and the virtue of being more elderly, may partly explain the lower use of adjuvant therapies in ≥75 group patients, which may affect longer term oncological outcomes (8, 22,24,25).…”