Tumour cell adhesion and integrin expression affected by Ganoderma lucidum

Wu, Qingping; Xie, Yizhen; Li, Sen-Zhu; Pierre, David P. La; Deng, Zhaoqun; Chen, Qi; Li, Chong; Zhang, Zhi; Guo, Jun; Wong, Chung-Kwun Amy; Lee, Daniel Y.; Yee, Albert; Yang, Burton B.

doi:10.1016/j.enzmictec.2005.10.034

Cited by 27 publications

(14 citation statements)

References 29 publications

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“…GLS is an herbal remedy containing multiple constituents, not all of which have been identified. However, the preparation is known to contain major bioactive components such as ergosterol, triterpenoids, unsaturated fatty acids, and polysaccharides, 12,[26][27][28] all of which are generally believed to be safe. Furthermore, in animal studies the LD50 of GLS has been shown to be more than 10.0 g/kg with no mutagenic or teratogenic action, which suggests that GLS is probably safe.…”

Section: Discussionmentioning

confidence: 99%

Ganoderma lucidum Spore Induced CA72-4 Elevation in Gastrointestinal Cancer

et al. 2013

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Ganoderma lucidum spore (GLS), an over-the-counter herbal supplement, is widely used by cancer patients in China. Although preclinical studies have shown it to be safe, complete safety data on GLS is still lacking. In this article, we report 5 cases of gastrointestinal cancer that were treated with GLS plus multiple strategies between 2010 and 2011. These patients presented with increased levels of the serum tumor marker CA72-4, one of the most valuable markers for monitoring therapeutic response in patients receiving gastrointestinal cancer treatment, after oral ingestion of GLS twice a day for 1 or 2 months. Interestingly, CA72-4 rapidly returned to normal levels when the patients discontinued the supplement and no change in clinical symptoms accompanied the CA72-4 surge. Taking into consideration that the underlying mechanism of this reaction is obscure, we suggest that additional studies are urgently needed and GLS be used with caution in cancer patients.

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Section: Discussionmentioning

confidence: 99%

Ganoderma lucidum Spore Induced CA72-4 Elevation in Gastrointestinal Cancer

et al. 2013

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“…cells in vitro (6), inhibited tumor cell adhesion (7), inhibited induced oxidative stress-invasiveness of cancer cells through suppression of interleukin (IL)-8 secretion (8), and suppressed motility and invasiveness of highly invasive breast and prostate cancer cells (9).…”

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confidence: 99%

Ganoderic Acid Me Inhibits Tumor Invasion Through Down-Regulating Matrix Metalloproteinases 2/9 Gene Expression

2008

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Abstract. The effect of ganoderic acid Me (GA-Me), which was purified from the fermentation mycelia of the traditional Chinese medicinal mushroom Ganoderma lucidum as reported (Tang W, Gu TY, Zhong JJ. Biochem Eng J. 2006;32:205-210), on anti-invasion was investigated. Wound healing assay indicated that GA-Me inhibited cell migration of 95-D, a human highly metastatic lung tumor cell line, in dose-and time-dependent manners. Results of cell aggregation and adhesion assays showed that GA-Me promoted cell homotypic aggregation and inhibited cell adherence to extracellular matrix (ECM). In addition, GA-Me suppressed matrix metalloproteinases 2 / 9 (MMP2 / 9) gene expressions at both mRNA and protein levels in 95-D cells according to qRT-PCR and Western blotting, respectively. The results demonstrated that GA-Me effectively inhibited tumor invasion, and it might act as a new MMP2 / 9 inhibitor for antimetastasis treatment of carcinoma cells.

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“…The possibility to have a supportive role in cancer treatment appears to be immunomodulation by protection DNA damage of normal cells through its powerful antioxidant mechanism and inhibition of tumor necrosis factor (TNF). There are a number of reports that have mentioned the benefit of this mushroom on various cancers (Wang et al, 1997;Sliva, 2003;Wu et al, 2006). The other herbs are the edible plants, Houttuynia cordata thunb (Hayashi et al, 1995) and the root of Boesenbergia pandurata Holtt (Murakami et al, 1995).…”

Section: Discussionmentioning

confidence: 99%