Tumour budding is a strong and independent prognostic factor in pancreatic cancer

Karamitopoulou, Evanthia; Zlobec, Inti; Born, Diana; Kondi-Pafiti, A; Lykoudis, Panagis M.; Mellou, Argyro; Gennatas, K; Gloor, Beat; Lugli, Alessandro

doi:10.1016/j.ejca.2012.10.022

Cited by 128 publications

(153 citation statements)

References 28 publications

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“…However, no separate analysis of SCC and AC was attempted concerning TNM-relevant clinicopathological features. Of note, a recent study presented at the Annual Meeting of the German Society of Pathology confirmed the association of TB with aggressive histopathology of esophageal and GI-junction AC on an independent set of 86 stage I–IV patients treated by primary resection (17). In particular, high-grade TB correlated significantly with advanced T-stage, higher tumor grade, non-intestinal/diffuse histological subtype, and higher rates of R1-resection.…”

Section: Tumor Budding In Carcinomas Of the Esophagus And Stomachmentioning

confidence: 82%

“…For the visualization of TB, two studies using cytokeratin staining were identified (14, 17), while the remaining studies are based on standard H&E staining (11–13, 15, 16, 18, 19). Methodologically, TB in esophageal SCC has been assessed in one densest high-power field (HPF, 200×) according to Ueno (22) by eight authors with variable modifications.…”

Section: Tumor Budding In Carcinomas Of the Esophagus And Stomachmentioning

confidence: 99%

“…Other authors have used the scoring approach suggested by Ohike (52) and the 10 HPF methods (25) (Tables 2 and 3). Only one study was identified assessing inter-observer variability for TB using a 10 HPF approach (17). Consequently, a systematic inter-observer study comparing different methods for the assessment of TB seems desirable both in SCC and AC to reach consensus on the optimal approach for daily diagnostic practice.…”

Section: Tumor Budding In Carcinomas Of the Esophagus And Stomachmentioning

confidence: 99%

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Tumor Budding in Upper Gastrointestinal Carcinomas

et al. 2014

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The basis of personalized medicine in oncology is the prediction of an individual’s risk of relapse and death from disease. The presence of tumor budding (TB) at the tumor–host interface of gastrointestinal cancers has been recognized as a hallmark of unfavorable disease biology. TB is defined as the presence of dedifferentiated cells or small clusters of up to five cells at the tumor invasive front and can be observed in aggressive carcinomas of the esophagus, stomach, pancreas, ampulla, colon, and rectum. Presence of TB reproducibly correlates with advanced tumor stage, frequent lymphovascular invasion, nodal, and distant metastasis. The UICC has officially recognized TB as additional independent prognostic factor in cancers of the colon and rectum. Recent studies have also characterized TB as a promising prognostic indicator for clinical management of esophageal squamous cell carcinoma, adenocarcinoma of the gastro-esophageal junction, and gastric adenocarcinoma. However, several important issues have to be addressed for application in daily diagnostic practice: (1) validation of prognostic scoring systems for TB in large, multi-center studies, (2) consensus on the optimal assessment method, and (3) inter-observer reproducibility. This review provides a comprehensive analysis of TB in cancers of the upper gastrointestinal tract including critical appraisal of perspectives for further study.

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Section: Tumor Budding In Carcinomas Of the Esophagus And Stomachmentioning

confidence: 82%

Section: Tumor Budding In Carcinomas Of the Esophagus And Stomachmentioning

confidence: 99%

Section: Tumor Budding In Carcinomas Of the Esophagus And Stomachmentioning

confidence: 99%

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Tumor Budding in Upper Gastrointestinal Carcinomas

et al. 2014

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“…Tumor budding is defined as the presence of five or more isolated cancer cells, or clusters of fewer than five cancer cells, that have detached from the neoplastic epithelium and migrated a short distance in the stroma of the tumor [23]. Tumor deposits can be identified by their discontinuous spread, venous invasion, or a totally replaced lymph node (defined as macroscopic or microscopic nests or nodules found in the lymph drainage area), without proof of residual lymph nodes in the nodule [24].…”

Section: Morphological Changes Of Cells During the Emtmentioning

confidence: 99%

“…Detachment of the tumor buds is fostered by the loss of E-cadherin expression. Activation of the Wnt pathway in tumor buds is supported by the nuclear expression of b-catenin, an increase of laminin 5 gamma 2, and the activation of Slug and ZEB1 [23].…”

Section: Morphological Changes Of Cells During the Emtmentioning

confidence: 99%