Tumour-associated eosinophilia: a review.

Lowe, David; Jorizzo, Johanna R.; Hutt, Msr

doi:10.1136/jcp.34.12.1343

Cited by 223 publications

(127 citation statements)

References 54 publications

Supporting

Mentioning

117

Contrasting

Unclassified

Order By: Relevance

“…MMP-1 was dmeonstrated to be intensely expressed in eosinophil (Ono et al, 1997;Gray et al, 1993) as our immunohistochemistry did (Fig. 5E, F) and good carcinoma prognosis has been shown to correlate with eosinophil infiltration (Lowe et al, 1981;Pretlow et al, 1983;Fisher et al, 1989;McGinnis et al, 1989;Sier et al, 1996). Recently, other MMP expression derived from the host cell such as macrophages or neutrophils was demonstrated to reflect the host defence against carcinoma cells (Takeha et al, 1997;Migita et al, 1999).…”

Section: Discussionmentioning

confidence: 97%

The clinical significance of MMP-1 expression in oesophageal carcinoma

et al. 2001

View full text Add to dashboard Cite

Summary Matrix metalloproteinase-1 (MMP-1) is involved in the degradation of interstitial collagen and thus thought to play a role in invasion of carcinoma. We investigated 51 oesophageal carcinoma patients to clarify the significance of MMP-1. MMP-1 mRNA was demonstrated to be expressed exclusively in almost all carcinoma tissue specimens (T) (94.1%) by reverse transcription-polymerase chain reaction, but not found in normal mucosal tissue specimens (N). The mean T/N ratio of MMP-1 was 42.5 and cases with T/N ≥ 10 had a higher incidence of cases involving muscularis propria than those with T/N < 10 which included all the cases involving the submucosa (P < 0.05). MMP-1 mRNA was significantly associated with both 40 kD (putative active MMP-1) and 50 kD (putative latent MMP-1) gelatinolytic bands (n = 17). These findings indicated that MMP-1 mRNA reflected the net function of MMP-1 and suggested MMP-1 to be involved in carcinoma invasive process. On the other hand, MMP-1 mRNA was inversely correlated with the patient prognosis (P < 0.01). These results indicated that MMP-1 might therefore play a crucial role in local invasion, but not in systemic dissemination. As a result, MMP-1 might be a novel prognostic factor independent from those previously reported in oesophageal carcinoma. 276-282 © 2001 Cancer Research Campaign doi: 10.1054/ bjoc.2000.1568, available online at http://www.idealibrary.com on http://www.bjcancer.com basal cell carcinoma and one adenocarcinoma. The depth of invasion of the tumour was as follows, 5 involved the submucosa, 7 involved the muscularis propria, and 39 involved the adventitia or more. The cases with lymph node metastases were classified into two groups: the non-metastatic group (n = 8) and metastatic group (n = 43). Carcinoma specimens were obtained from the tumour edge, avoiding a necrotic centre and corresponding distant normal mucosa specimens were also obtained at least 5 cm away from the tumour edge by sharply dissecting the mucosa off the muscularis propria. All specimens were quick-frozen in liquid nitrogen and stored at Ϫ80˚C until processing.When obtaining the tumour tissue from the surgical specimens, we have carefully chosen the area where abundant tumour cells seemed to be contained. The cut surface of the tumour centre indicate the whitish area where usually contain a lot of tumour cells. Moreover we reviewed the specimens histologically, and almost all specimens (47/51) were ascertained that more than 80% area contained tumour cells and the remaining 4 showed that tumour cells occupied more than 70%. Thus we think the used specimens were good for the molecular analysis. RNA extraction, reverse transcription-polymerase chain reaction (RT-PCR) and Northern blot hybridizationTotal RNA isolation Frozen-tissue specimens were homogenized in guanidium thiocyanate and total RNAs were obtained by ultracentrifugation through a cesium chloride cushion as described previously (Mori et al, 1993;Yamashita et al, 2000).cDNA preparation and RT-PCR Eight µg of each total RNA was re...

show abstract

Section: Discussionmentioning

confidence: 97%

The clinical significance of MMP-1 expression in oesophageal carcinoma

et al. 2001

View full text Add to dashboard Cite

show abstract

“…However, in many cancers, notably in carcinoma, eosinophils recruitment, commonly referred to as tumor-associated tissue eosinophilia (TATE), has been observed in some patients in tumor vicinity (3,4). Several epidemiological studies have attempted to correlate TATE and cancer prognosis or to study the relationships between allergy-related disorders and cancer development (5,6). Even though the beneficial effect of TATE remains controversial, the presence of eosinophils appears as an indicator of good prognosis indicator in some cancers, such as head and neck cancers (7)(8)(9) and gastrointestinal cancers (10), particularly in colorectal cancers, in which high eosinophil counts were associated to increased 5-y survival (11).…”

mentioning

confidence: 99%

Human Eosinophils Exert TNF-α and Granzyme A-Mediated Tumoricidal Activity toward Colon Carcinoma Cells

Legrand

Driss

Delbeke

et al. 2010

The Journal of Immunology

144

135

View full text Add to dashboard Cite

Peripheral blood and tissue eosinophilia is a prominent feature in allergic diseases and helminth infections. In cancer patients, tumor-associated tissue eosinophilia is frequently observed. Tumor-associated tissue eosinophilia can be associated with a favorable prognosis, notably in colorectal carcinoma. However, underlying mechanisms of eosinophil contribution to antitumor responses are poorly understood. We have in this study investigated the direct interactions of human eosinophils with Colo-205, a colorectal carcinoma cell line, and show that eosinophils induce apoptosis and directly kill tumor cells. Using blocking Abs, we found that CD11a/CD18 complex is involved in the tumoricidal activity. Coculture of eosinophils with Colo-205 led to the release of eosinophil cationic protein and eosinophil-derived neurotoxin as well as TNF-α secretion. Moreover, eosinophils expressed granzyme A, which was released upon interaction with Colo-205, whereas cytotoxicity was partially inhibited by FUT-175, an inhibitor of trypsin-like enzymatic activity. Our data present the first demonstration, to our knowledge, that granzyme A is a cytotoxic mediator of the eosinophil protein arsenal, exerting eosinophil tumoricidal activity toward Colo-205, and provide mechanistic evidence for innate responses of eosinophil against tumor cells.

show abstract

“…Acute eosinophilic leukemia is a rare disorder that almost always presents with hypereosinophilia and is distinguished by the marked increase in immature eosinophils in the blood and bone marrow [5]. Hypereosinophilia is encountered with less frequency in malignancies of the head and neck, ovaries, uterus, breast, pancreas, lungs, liver, thyroid gland, and gastrointestinal tract [5,13,14]. Soft-tissue sarcomas are rarely associated with hypereosinophilia, and only 7 cases have been described in the literature [12,[14][15][16].…”

Section: Discussionmentioning

confidence: 99%

Hypereosinophilia associated with cardiac rhabdomyosarcoma

Fox

Ferrari

et al. 2003

American J Hematol

View full text Add to dashboard Cite

Hypereosinophilia, defined as an absolute eosinophil count exceeding 1,500/mm 3 , is caused by a limited number of disorders. Its association with malignancy is a rare occurrence that typically denotes extensive metastasis and a poor prognosis. Several theories have been proposed to explain the hypereosinophilia associated with malignancy, focusing on the production of eosinophilopoietic cytokines by tumors. We describe a patient with hypereosinophilia associated with a cardiac rhabdomyosarcoma, review the etiologies of hypereosinophilia, and discuss the possible mechanisms. Am. J. Hematol. 74:64-67, 2003.

show abstract

Tumour-associated eosinophilia: a review.

Cited by 223 publications

References 54 publications

The clinical significance of MMP-1 expression in oesophageal carcinoma

The clinical significance of MMP-1 expression in oesophageal carcinoma

Human Eosinophils Exert TNF-α and Granzyme A-Mediated Tumoricidal Activity toward Colon Carcinoma Cells

Hypereosinophilia associated with cardiac rhabdomyosarcoma

Contact Info

Product

Resources

About