Tumour Angiogenesis in Rectal Cancer-Computer-Assisted Endosonographic and Immunohistochemical Methods for Assessment

Tankova, Ludmila; Kovatchki, Daniel; Stoilov, Georgi; A, Gegova; Terziev, Ivan

doi:10.5772/25336

Cited by 2 publications

(3 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…5,[7][8][9] Other studies have demonstrated that moderately and poorly differentiated tumors present with higher malignant potential, through the higher incidence of lymphatic, venous invasion and lymph node and hepatic metastasis. 5,8,10 The data in the present study show a non-significant statistical difference in higher microvessel density of moderately and poorly differentiated tumors. This finding was in accordance to the study done by Tarta et al which also showed a non -significant difference with higher microvessel density in moderately and poorly differentiated tumors.…”

Section: Discussioncontrasting

confidence: 48%

“…MVD is significantly higher in more advanced tumor stages and may be used as a determinant of survival in patients with rectal cancers. 7,10 There is a significant correlation of MVD with Dukes′ stage and lymph node involvement. 7,10,15 However, in our study significant correlation was not observed between the microvessel density and clinical stage.…”

Section: Discussionmentioning

confidence: 99%

“…7,10 There is a significant correlation of MVD with Dukes′ stage and lymph node involvement. 7,10,15 However, in our study significant correlation was not observed between the microvessel density and clinical stage.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Angiogenesis in Colorectal Carcinoma: An Immunohistochemical study

Maskey¹,

Karki²,

Pradhan³

et al. 2022

Nep. J. Cancer

View full text Add to dashboard Cite

Background: Angiogenesis plays an important role in carcinogenesis. Angiogenesis is studied by calculating the microvessel density. The purpose of this study is to determine whether angiogenesis can be documented in colorectal tumor progression and to assess whether the quantification of microvessels can be correlated to tumor aggressiveness. Methods: This is a hospital based descriptive cross-sectional study, done from August 2015 to July 2016 after obtaining ethical approval from Institutional Review Committee. We quantified microvessel density in colorectal carcinoma. An immunohistochemical study was performed using mouse monoclonal antibody against CD34, which was used for localizing endothelial cell lined blood vessels & cluster of endothelial cells without lumen formation. Counting was done in 10 consecutive high power fields (40x). The data were analyzed after the counting was done. Results: We compared microvessel density with age, gender, tumor size, histologic differentiation, tumoral invasion, lymph node metastasis and tumor stage. No significant correlation was found between microvessel density and the aforementioned parameters (p>0.05). Conclusions: The correlation between microvessel density and tumor progression was non-significant. Hence we conclude that there is a need to undertake studies involving larger samples, and also assessment of the other factors associated with angiogenesis should be done to have a better information on prognostic values

show abstract

Section: Discussioncontrasting

confidence: 48%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Angiogenesis in Colorectal Carcinoma: An Immunohistochemical study

Maskey¹,

Karki²,

Pradhan³

et al. 2022

Nep. J. Cancer

View full text Add to dashboard Cite

show abstract

Ultrasound Methods for Lower Rectal Cancer Staging

Churchev¹

2014

JGPLD

View full text Add to dashboard Cite

By endorectal ultrasonography the rectal tumors can be evaluated for their size, stage, echostructure and vascularization. Cancers in the parts of the colon beyond the rectum usually are not staged with ultrasound methods, because the primary treatment-surgical resection gives the means for definite pathohistological staging and grading. The forward-viewing radial-array echoendoscopes gives the ability to reach and evaluate these lesions. The accuracy of the collected data and its significance for clinical practice in the cases of colon tumors has to be verified by larger systematic studies [4]. The endosonographic image of rectal carcinoma is one of a hypoechoic, heterogenic lesion and the degree to which it disrupts the rectal wall layers determines the local tumor T-stage.

show abstract

Tumour Angiogenesis in Rectal Cancer-Computer-Assisted Endosonographic and Immunohistochemical Methods for Assessment

Cited by 2 publications

References 42 publications

Angiogenesis in Colorectal Carcinoma: An Immunohistochemical study

Angiogenesis in Colorectal Carcinoma: An Immunohistochemical study

Ultrasound Methods for Lower Rectal Cancer Staging

Contact Info

Product

Resources

About