Tumors

Hefti, Fritz; Jundt, Gernot

doi:10.1007/978-3-662-46810-4_13

Cited by 1 publication

(5 citation statements)

References 155 publications

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“…This is 2–6 times longer than delays in Ewing sarcomas located at other sites of the skeleton [2, 11–13]. These findings are consistent with Adkins et al [14] and Metcalfe and Grimer [15] reporting on a delay of 11,75 and 14 months.…”

Section: Discussionsupporting

confidence: 86%

“…Delays seen in diagnosis of osteosarcomas in our study (median of 15 months), as with Ewing sarcomas, were considerably longer (4.5- to 14-fold) than reported for osteosarcomas at other sites [2, 11, 12, 16, 17]. Likewise, the volume of these tumors was much smaller than reported for tumors at other sites.…”

Section: Discussioncontrasting

confidence: 52%

“…One reason for the high number of patients with an inadequate treatment is the long follow-up of the study; diagnoses and treatments were performed in the 1970s and 1980s. Meanwhile, the treatment regimens have markedly changed—for example, multimodal therapy regimes including chemotherapy—and have led to significant improvements in the outcome for patients with sarcomas [2, 3, 14, 19, 26–28]. …”

Section: Discussionmentioning

confidence: 99%

“…They are benign in 75%–85% of cases and malignant in 15%–25% [2, 5, 6]. The bone most commonly affected is the calcaneus, followed by metatarsal and phalangeal bones [1, 7].…”

Section: Introductionmentioning

confidence: 99%

“…The bone most commonly affected is the calcaneus, followed by metatarsal and phalangeal bones [1, 7]. Chondrosarcoma is the most frequent malignant tumor of the foot, followed by Ewing sarcoma and osteosarcoma [1, 2]. Although there is no thick soft tissue layer to potentially cover a developing mass, a relatively long delay in diagnosis has been reported for such tumors [8].…”

Section: Introductionmentioning

confidence: 99%

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Do Malignant Bone Tumors of the Foot Have a Different Biological Behavior than Sarcomas at Other Skeletal Sites?

Brotzmann

Hefti

Baumhoer

et al. 2013

Sarcoma

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We analyze the delay in diagnosis and tumor size of malignant bone tumors of the foot in a retrospective study. We compared the oncological and surgical long-term results with identical tumor at other anatomical sites in order to analyze the biological behavior of sarcomas that are found in the foot. Thirty-two patients with a histologically proven malignant bone tumor (fifteen chondrosarcomas, nine osteosarcomas, and eight Ewing sarcomas) between the years 1969 and 2008 were included. The median follow-up was 11.9 years. The overall median time gap between the beginning of symptoms and diagnosis in the study group was 10 months. Ewing sarcoma presented with the longest delay in diagnosis (median of 18 months), followed by osteosarcoma (median of 15 months) and chondrosarcoma (median of 7.5 months). The delay in diagnosis of these tumors was significantly longer than that of equivalent tumors at other skeletal sites, but the 5- and 10-year survival rates and the occurrence of distant metastases were comparable. In contrast, the average size of foot tumors was 5- to 30-fold less than that of tumors analyzed at other skeletal sites. This study indicates that sarcomas of the foot demonstrate a distinct biological behavior compared to the same tumor types at other skeletal sites.

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Section: Discussionsupporting

confidence: 86%

Section: Discussioncontrasting

confidence: 52%

Section: Discussionmentioning

confidence: 99%

“…They are benign in 75%–85% of cases and malignant in 15%–25% [2, 5, 6]. The bone most commonly affected is the calcaneus, followed by metatarsal and phalangeal bones [1, 7].…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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