Tumors of the Testicle With Dermatologic Sequelae

Murrell, Thomas W.; A, Pepple

doi:10.1001/archderm.1948.01520190009002

Cited by 10 publications

(3 citation statements)

References 4 publications

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“…In the literature, skin has been rarely reported as a site of metastatic testictilar choriocarcinoma. Mtirrell & Pepple reported a case of metastatic choriocarcinoma from the testis to the scalp, abdominal wall and right lower leg occurring after primaiy diagnosis was made (9). A case of metastatic disease to the lip containing a choriocarcinomatous component f'rom testicular embiyonal carcinoma was also reported by Reingold in his study of 32 autopsied cases with cutaneous metastases from internal malignancy (4).…”

Section: Discussionmentioning

confidence: 96%

Choriocarcinoma presenting as a cutaneous metastasis

et al. 1995

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The rare presentation of choriocarcinoma as a cutaneous metastasis in a 23-year-old male is reported. Histological and immunohistochemical analysis of the biopsy material demonstrated two distinct cell populations, syncytiotrophoblasts and cytotrophoblasts, with syncytiotrophoblasts strongly positive for human chorionic gonadotropin antigen. Subsequent clinical evaluation revealed a testicular tumor with metastases to lungs, brain, liver and kidney and increased serum levels of human chorionic gonadotropin. The patient died shortly after diagnosis due to complications of metastatic disease despite chemotherapy.

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Section: Discussionmentioning

confidence: 96%

Choriocarcinoma presenting as a cutaneous metastasis

et al. 1995

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“…Unfortunately, Reingold did not include histopathologic illustrations of his case for comparison. Another report 13 of a choriocarcinoma of the testis metastatic to scalp stated that the cutaneous metastases appeared after primary diagnosis had already been made. An additional report 14 described a woman who developed multiple skin metastases following a miscarriage, but this report did not have histopathologic confirmation.…”

Section: Discussionmentioning

confidence: 99%

“…Choriocarcinoma has a distinct propensity to spread hematogenously and the principal sites of involvement include lung, liver, intestines, spleen, adrenals, and brain 9 . Reports of metastatic choriocarcinoma infrequently mention the skin as a site of metastasis 6,7,12–15 . Reingold 12 reported 32 necropsied cases with cutaneous metastases from internal carcinoma.…”

Section: Discussionmentioning

confidence: 99%

Choriocarcinoma of the Testis Metastatic to the Skin

Requena

Sánchez

Aguilar

et al. 1991

The Journal of Dermatologic Surgery and Oncology

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A case of choriocarcinoma of the testis metastatic to the skin is reported. In this case report the primary tumor was first diagnosed by the histopathologic findings in the cutaneous biopsy of a single nodule that appeared on the chest, with both syncytiotrophoblastic and cytotrophoblastic cells in the metastatic solid tumor islands. Using peroxidase-antiperoxidase techniques, beta-human chorionic gonadotropin (beta-HCG) was positive within the cytoplasm of syncytiotrophoblastic cells. The patient was treated with orchiectomy, chemotherapy, and radiotherapy. With these measures there was a decrease of chorionic gonadotropin serum levels to normal limits and 2 years after this treatment there is no evidence of recurrence.

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Metastases to Skin From Occult Malignant Neoplasms

Price¹

1974

Arch Dermatol

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Tumors of the Testicle With Dermatologic Sequelae

Cited by 10 publications

References 4 publications

Choriocarcinoma presenting as a cutaneous metastasis

Choriocarcinoma presenting as a cutaneous metastasis

Choriocarcinoma of the Testis Metastatic to the Skin

Metastases to Skin From Occult Malignant Neoplasms

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