Tumors of the Nervous System

Higgins, Robert; Bollen, Andrew W.; Dickinson, Peter J.; Sisó-Llonch, Sílvia

doi:10.1002/9781119181200.ch19

Cited by 114 publications

(365 citation statements)

References 134 publications

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“…Furthermore, a mixture of granular cells and neoplastic meningeal cells has been described in animals ( Higgins et al . ).…”

Section: Discussionmentioning

confidence: 97%

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Intradural extramedullary granular cell tumour in a cat

Valentini

Canal²,

Balducci³

et al. 2018

J of Small Animal Practice

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A 7-year-old domestic shorthair cat was evaluated for progressive paraparesis, inability to jump, a paralysed tail and inability to void the bladder. Neurologic examination was consistent with a L4-S3 localisation. Survey radiographs of the lumbar vertebral column revealed L4-L7 vertebral body remodelling. A pre-contrast T1-weighted hyperintense, diffusely enhancing intradural lesion extending from L4 to S1 vertebral bodies was detected by MRI. Large, mesenchymal, round-to-polygonal cells arranged in nests or sheets were found on histologic examination at post mortem. These cells were characterised by abundant intracytoplasmic PAS-positive, diastase-resistant granules and positive immunoexpression of vimentin, S-100, neuron-specific enolase and desmin. This is the first report of a spinal granular cell tumour in a cat.

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“…Furthermore, a mixture of granular cells and neoplastic meningeal cells has been described in animals ( Higgins et al . ).…”

Section: Discussionmentioning

confidence: 97%

“… , Higgins et al . ). GCTs comprise a large number of neoplasms occurring both within the nervous system and extraneurally ( Mandara et al .…”

Section: Introductionmentioning

confidence: 97%

Intradural extramedullary granular cell tumour in a cat

Valentini

Canal²,

Balducci³

et al. 2018

J of Small Animal Practice

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“…Although the most recent cancer literature in veterinary medicine includes the brain as the site of metastases of OSA (8), the scarcity of reports in the main databases still leads us to agree with previous literature that indicate the rarities of these cases (13). A retrospective study of extraskeletal OSA (OES) in 169 dogs and a comparative evaluation of OSA in dogs and humans described metastasis in lymph nodes, lungs, kidneys, spleen, bone marrow, tegument, but did not mention the brain (9,14).…”

Section: Discussionmentioning

confidence: 99%

“…For this highly debilitating characteristic, most of the cases of CVA in the veterinary literature are associated with malignancies, mainly intravascular angiocentric lymphomas. (5,6,8).…”

Section: Introductionmentioning

confidence: 99%

Metastatic osteosarcoma as a cause of hemorrhagic stroke in a dog

Cristo¹,

Vargas²,

Biezus³

et al. 2017

Braz. J. Vet. Pathol.

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Cristo, et al.; Metastatic osteosarcoma as a cause of hemorrhagic stroke in a dog. Braz J Vet Pathol, 2017, 10(3), 105 -110 DOI: 10.24070/bjvp.1983-0246.v10i3p105-110 AbstractThe aim of this case report is to describe an uncommon hemorrhagic cerebrovascular accident (CVA) associated with an osteosarcoma (OSA) metastasis. Cerebrovascular accident (CVA) is the acute onset of a neurological deficit from any change in blood supply resulting from a pathological process, characterizing a stroke and among all the causes, the neoplastic thrombus of osteosarcoma, specifically, is the most infrequent in clinical practice. A seven-year-old female midsize mixed-breed dog was submitted to a forelimb amputation for showing an osteoblastic OSA in proximal humerus. Three weeks later, the patient presented uninterruptible seizure and coma, resulting in death. At necropsy, it was observed a friable and reddish mass in the left frontal cortex which, microscopically was constituted by OSA metastasis in association with multiple ruptures of blood vessels and focally extensive severe bleeding, which caused a CVA. At immunohistochemistry, neoplastic cells of the humerus and the brain metastasis were positive for vimentin and osteonectin, confirming the diagnosis of osteoblastic OSA. The reports about OSA metastasis on the brain are rare in animals and humans, what could be related to the low frequency and few diagnosis ante and post-mortem. As uncommon as the description of OSA metastasis to the brain, is the CVA associated to them, demonstrating that reporting cases related to these clinical and anatomopathological lesions are important for the scientific community.

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“…Segundo Azim et al (2017), em mulheres, há maior risco de ocorrer metástase cerebral quando já ocorreu metástase pulmonar; e outros fatores que também podem influenciar são o menor intervalo de recidiva e expressão de HER2 (receptor do fator de crescimento epidérmico humano tipo 2). Em animais domésticos, Higgins et al (2017) apontaram os carcinomas nasal, pulmonar, mamário e renal como aqueles que apresentaram sítios de metástase no sistema nervoso central mais frequentemente. No presente caso o animal apresentou inicialmente metástase em linfonodo e, posteriormente, metástase pulmonar e cerebral.…”

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Metástase De Carcinoma Mamário Em Sistema Nervoso Central De Cadela

Castro¹,

Gouveia²,

Silva³

et al. 2017

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RESUMOMetástases de carcinoma mamário podem ocorrer em vários tecidos, porém são incomuns no sistema neural. Objetivou-se relatar um caso de neoplasia mamária primária com metástase no cérebro, cerebelo, pulmão e linfonodo. O animal em questão era uma cadela da raça Shih-Tzu de sete anos de idade, com histórico de neoplasia mamária com recidiva após exérese cirúrgica. O diagnóstico da neoplasia mamária foi carcinoma tubular com êmbolos neoplásicos em vasos linfáticos e metástase em linfonodo. Após a exérese cirúrgica a cadela retornou para atendimento apresentando sintomatologia compatível com síndrome vestibular. Foi realizada a eutanásia e durante a necropsia observou-se massa no lobo caudal do pulmão direito, assim como aderência da dura-máter no osso temporal e occipital, na região do hemisfério cerebral direito e cerebelo, respectivamente. Após retirada do encéfalo e cerebelo verificou-se presença de duas massas localizadas no encéfalo e cerebelo, respectivamente. A massa localizada no encéfalo direito adentrava a substância branca, apresentava coloração pardacenta, bordas ligeiramente irregulares, medindo aproximadamente 2,5 cm de diâmetro, em contrapartida, a massa no cerebelo era elevada, brancacenta, de formato irregular, medindo aproximadamente 2,0 cm de diâmetro. Microscopicamente havia áreas multifocais, circunscritas, de proliferação de células epiteliais, formando ácinos, compatíveis com metástase de carcinoma mamário. As metástases pulmonares de carcinoma mamário são comuns, porém infrequentes no sistema neural. No caso em questão os sinais neurológicos apresentados pelo animal foram ocasionados pela metástase de carcinoma mamário reforçando a necessidade de diagnóstico precoce e acompanhamento de cadelas portadoras de tumores de mama, mesmo após a exérese cirúrgica. PALAVRAS-CHAVE: canino, disseminação, neoplasia mamária.

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Tumors of the Nervous System

Cited by 114 publications

References 134 publications

Intradural extramedullary granular cell tumour in a cat

Intradural extramedullary granular cell tumour in a cat

Metastatic osteosarcoma as a cause of hemorrhagic stroke in a dog

Metástase De Carcinoma Mamário Em Sistema Nervoso Central De Cadela

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