Tumors of the heart and pericardium

Scott, Roy W.; Garvin, Curtis F.

doi:10.1016/s0002-8703(39)90593-4

Cited by 125 publications

(12 citation statements)

References 7 publications

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“…Until recent times the description of métastases into the heart could be found mainly in works devoted to the study of morphological material [9,15,18]. Clinical man ifestations of heart tumors have been so far assessed, first and foremost, on the basis of retrospective analy sis, as the diagnosis has been chiefly detected at autop sies.…”

Section: Discussionmentioning

confidence: 99%

Secondary Malignant Lesions of the Heart and Pericardium in Neoplastic Disease

Lv¹

1986

Oncology

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The present work is based on the analysis of clinical data and instrumental studies of 240 patients with metastases and malignant tumors extended to the heart and pericardium. Tumor lesion process of the pericardium is accompanied by the complex of symptoms of acute pericarditis (fibrosis, effusional, constrictive), rapid enlargement of the heart shadow, in combination with changes of voltage and ECG complexes, appearance of echo-free spaces, presence of atypical cells in pericardial effusion. The process of tumor extension to the myocardium is characterized by the following factors: progressive refractory cardiac decompensation, steady rhythm disturbances without any dynamic changes, appearance of stenosal murmurs, enlargement and blurredcontours of the heart shadow on chest roentgenograms, appearance of echocardiographic spaces with akinesia and hyperkinesia.

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Section: Discussionmentioning

confidence: 99%

Secondary Malignant Lesions of the Heart and Pericardium in Neoplastic Disease

Lv¹

1986

Oncology

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“…There are many causes of pericardial effusion and it is useful to classify them etiologically, since this disorder is the most common pathologic process involving the pericardium [3,32]. They include first viral, bacterial, fungal or rickettsial infections, second non-infectious diseases like acute myocardial infarctions, radiation, trauma, storage diseases, neoplastic disorders and third pericardial effusion presumbly related to hypersensitivity and autoimmunity for example in rheumatoid arthritis [8,29].…”

mentioning

confidence: 99%

Cytokine Activation in Pericardial Fluids in Different Forms of Pericarditis

Pankuweit

Wädlich²,

Meyer³

et al. 2000

Herz

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There are many causes of pericardial effusion and it is useful to classify them etiologically, since this disorder is the most common pathologic process involving the pericardium. This report details our experience with pericardioscopy and epicardial biopsy in 101 patients with pericardial effusions in whom pericardioscopy was performed. By means of clinical data and polymerase chain reaction we tried to elucidate the etiology of the pericardial effusion which were classified as follows: we found 41 effusions to be induced by primary malignant tumors or tumors metastatic to the pericardium. Specific diagnosis of viral and bacterial pericarditis was established in 17 patients by examination of the pericardial effusion with PCR, where we found 3 patients positive for adenovirus, 5 patients positive for cytomegalovirus, 2 patients positive for enterovirus-RNA and 5 patients positive for borrelia Burgdorferi-DNA. Additionally, idiopathic effusions (lymphocytic and autoreactive) were seen in 35 patients. In summary immunological and molecular biology investigations seem to provide an additional tool in the diagnostic of pericardial effusion with unknown etiology. If we focus on the ELISA results, there is some evidence, that the demonstration [table: see text] of activation markers and soluble mediators of inflammation such as Il-6, Il-8 and IFN-gamma in pericardial effusion and the simultaneously lack of these mediators in sera of the patients first may be helpful in the discrimination of autoreactive and lymphocytic effusion. Second, this cytokine pattern or distribution indicates a possible local inflammatory process, where these cytokines were all released from activated T lymphocytes present in lymphocytic effusion. In the future, this may have therapeutic implications.

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“…Approximately 75% of malignant pericardial effusions are clinically diagnosed. 9 Almost all tumors can potentially involve the pericardium and result in an effusion. Malignant pericardial effusion often has an insidious clinical onset that can mimic the picture of disseminated carcinomatosis.…”

Section: Discussionmentioning

confidence: 99%

Incidence of Malignancy Related Pericardial Effusion in a Tertiary Hospital

et al. 2017

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Back ground: Malignancy related pericardial effusion (PE) may represent a terminal event in patients with therapeutically unresponsive disease. Pericardial tamponade (PT) is a co morbid condition in many diagnosed malignant cases. Selection of patients with malignancies who are responsive to available treatment may achieve significant improvement in palliation. Early detection of pericardial tamponade and appropriate intervention (Pericardiocentesis) or Subxyphoid pericardiotomy may result long term survival benefit.Objective: Early detection and management of PE and tamponade in malignant cases.Methods: Color Doppler (C-D) echocardiography was done in 260 patients with underlying malignancies on chemo or radiotherapy from oncology department of Delta Medical college and hospital from May 2016 to December 2016. These cases were reviewed retrospectively for clinical features, diagnosis and therapy for their malignancy.Results: 81% have shortness of breath, sign of pulsus paradoxus and pericardial tamponade were found in 22% and 5% patients respectively. During echocardiography, pericardial effusion was found in 102 patients. 65% have mild pericardial effusion, whereas 27% have moderate and 8% have severe PE. Effusions with malignancy comprising of 40% adenocarcinomas of lung, 15% carcinoma (Ca) of pharynx, 10% Ca breast, 10% lymphoma, 10% is Carcinoma of unknown primary, 8% Ca esophagus and 7% others (Renal, Hepatic, ovary & cheek).University Heart Journal Vol. 12, No. 1, January 2016; 23-25

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Tumors of the heart and pericardium

Cited by 125 publications

References 7 publications

Secondary Malignant Lesions of the Heart and Pericardium in Neoplastic Disease

Secondary Malignant Lesions of the Heart and Pericardium in Neoplastic Disease

Cytokine Activation in Pericardial Fluids in Different Forms of Pericarditis

Incidence of Malignancy Related Pericardial Effusion in a Tertiary Hospital

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