“…In the 1930s, Meigs, an American gynecologist, was the first to advocate cytoreductive surgery followed by adjuvant radiotherapy in patients with ovarian cancer, a disease with a very high propensity to disseminate to the peritoneum. 37 The survival rate after cytoreductive surgery for the treatment of ovarian cancer, however, remained poor. As a result, treatment of ovarian cancer mainly depended on chemotherapy, and surgical strategies were not optimized until the late 1960s and 1970s, when Munnell and Griffiths independently demonstrated that better survival rates could be achieved by more extensive surgery with the size of residual disease being the most important prognostic factor.…”