Tumors of the Endocrine Glands

Capen, Charles C.

doi:10.1002/9780470376928.ch13

Cited by 92 publications

(188 citation statements)

References 223 publications

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“…Based on morphological and immunohistochemical findings, the diagnosis was malignant aortic body tumor and PHS, which is similar to previous descriptions of these tumors in dogs [1][2][3][4][5]7]. The expression of chromogranin A and synaptophysin in the heart base tumor was low; this might indicate malignancy, since it has been reported that concentration of secretory granules of chromogranin is diminished in malignant tumors [2].…”

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confidence: 61%

Simultaneous Aortic Body Tumor and Pulmonary Histiocytic Sarcoma in a Flat-Coated Retriever

Nakagawa

Sakai

Yanai

et al. 2009

The Journal of Veterinary Medical Science

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ABSTRACT. A case of multiple primary tumors observed in the heart base and in the lung of a 7-year-old intact female, flat-coated retriever was reported. Morphological differences between both tumors and detailed immunohistochemical study revealed that the cardiac neoplasm was as a malignant aortic body tumor and the lung tumor was a pulmonary histiocytic sarcoma. The occurrence of aortic body tumor with other primary neoplasms has been previously reported in animals suggesting that this might be a common presentation in dogs.KEY WORDS: aortic body tumor, canine, multiple tumor, pulmonary histiocytic sarcoma.J. Vet. Med. Sci. 71(9): 1221-1223, 2009 Multiple primary tumors (MPTs) were defined as multiple autonomously originating tumors in an individual patient by Warren and Gates [18]. The occurrence of more than 1 primary cancer in an animal, previously only a medical curiosity, has now become a worldwide problem; however, there are few studies on this interesting entity in veterinary literature [8,9,16]. The present paper describes the histopathological and immunohistochemical findings of a malignant aortic body chemodectoma and pulmonary histiocytic sarcoma (PHS) in a flat-coated retriever.A 7-year-old intact female, flat-coated retriever was admitted to the Veterinary Hospital, Gifu University, Japan, with severe dyspnea. Thoracic X-ray images revealed severe pleural effusion and a large heart-base tumor. At needle thoracocentesis an opaque, red-whitish (chylous effusion) fuid was observed. A sample of the pleural effusion was collected for cytology, which demonstrated mesothelial cells, macrophages, and lymphocytes, suggestive of modified transudate. Neoplastic cells were not observed. Despite symptomatic treatment, in early July, she showed severe subcutaneous edema and dyspnea and died during hospitalization.Necropsy revealed 2 hard, encapsulated, reddish, coalescent masses (8  7  6 cm and 3  3  2 cm) arising at the heart base, around the ascending aorta (Fig. 1a). Moreover, a large (7  5 cm) whitish mass with an irregular surface was observed in the right caudal pulmonary lobe (Fig. 2a). The thoracic cavity contained approximately 2.5 l of an opaque, red-whitish fluid (chylous effusion) with a moderate amount of fibrin, hydropericardium, concentric hypertrophy of the left ventricule, and ascites. On the other organs, abnormality was not seen.In microscopic observation, the cardiac neoplasm was comprised of multiple lobules separated by fine connective tissue septa. The tumor cells were cuboidal to polyhedral with lightly basophilic granular cytoplasm and prominent round nuclei (Fig. 1b). Mitotic figures were frequent, and some blood vessels showed neoplastic invasion. In the lung, round to polyhedral tumor cells arranged in a solid pattern were observed to replace the pulmonary parenchyma, while there were areas preserving normal alveolar and bronchiolar architecture. These cells had ample eosinophilic cytoplasm and round to oval nuclei (Fig. 2b). Binucleated and multinucleated giant cells, a small n...

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confidence: 61%

Simultaneous Aortic Body Tumor and Pulmonary Histiocytic Sarcoma in a Flat-Coated Retriever

Nakagawa

Sakai

Yanai

et al. 2009

The Journal of Veterinary Medical Science

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“…Unilateral involvement with thyroid carcinomas, as was observed in both dogs reported here, is approximately twice as frequent in dogs as the involvement of both lobes (CAPEN, 2002). Carcinomas are generally poorly encapsulated and invade locally into the wall of the trachea, cervical muscles, esophagus, larynx, nerves and vessels (CAPEN, 2007).…”

Section: Microscopicamente Ambos Os Neoplasmas Primários Eram Caractmentioning

confidence: 93%

“…In dogs, thyroid carcinomas are more frequent and often have both follicular and compact cellular growth pattern. The most common metastatic site is the lung; the retropharyngeal and caudal cervical lymph nodes are less frequently affected (CAPEN, 2002). The aim of this report is to describe two cases of thyroid carcinoma with infrequent metastatic pattern and secondary mielopathy.…”

Section: Microscopicamente Ambos Os Neoplasmas Primários Eram Caractmentioning

confidence: 99%

“…In the same case, the esophageal tunica adventitia was invaded, and there was a neoplastic thrombus in the cranial vena cava. The lungs and the regional lymph nodes are the most common metastatic sites (CAPEN, 2002). Early invasion into the branches of the cranial and caudal thyroid veins with the formation of tumor cell thrombi leads to multiple pulmonary metastases, often before the involvement of the retropharyngeal and caudal cervical lymph nodes (CAPEN, 2007), as noted in case 2.…”

Section: Microscopicamente Ambos Os Neoplasmas Primários Eram Caractmentioning

confidence: 99%

“…The higher risk among Boxers is thought to be partly due to the anomalous follicular patterns commonly seen in their thyroid gland. Dachshunds are not listed as a breed predisposed to developing thyroid carcinoma (CAPEN, 2002).…”

Section: Microscopicamente Ambos Os Neoplasmas Primários Eram Caractmentioning

confidence: 99%

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