Tumors of the appendix

Abstract

An analysis of 101 tumors of the appendix is presented. During the period under study (from 1949 to 1972), 8,699 appendectomies had been performed. Only 17 of the 101 tumors were malignant. In this group, there were two primary carcinomas, 12 metastatic carcinomas, and three lymphomas. Most of the tumors (84) were benign, including 43 carcinoids, 32 mucoceles, five neuromas, two leiomyomas, and two villous adenomas, Some of the clinical and pathologic features of carcinoids, adenocarcinoma, and mucoceles are discussed. The most significant observation in this study is the statistically significant evidence that, even without associated acute appendicitis, mucoceles 2 cm or more in diameter probably do cause clinical symptoms, which may be alleivated by appendectomy.

Crohnʼs Disease Patient with Right Lower Quadrant Abdominal Pain for 20 Years Due to an Appendiceal Neuroma (Fibrous Obliteration of the Appendix)

“…[4][5][6] The association of appendiceal neuromas (fibrous obliteration of the appendix) with clinical symptoms, such as abdominal pain, has been unclear. 1,2 Most appendiceal neuromas are found incidentally in asymptomatic patients after pathological examination of the appendix reveals fibrous obliteration. 7,8 However, in chronic appendicitis the incidence of appendiceal neuromas has been reported to be as high as 51.2%.…”

Appendiceal neuroendocrine neoplasms: diagnosis and management

“…The rate of aNENs presence in patients undergoing appendicectomy is reported to be 0.3-0.9% (Moertel et al 1968, Connor et al 1998, Tchana-Sato et al 2006, Debnath et al 2008, In't Hof et al 2008, Shapiro et al 2010, Yilmaz et al 2013; however, in some series, it has been reported to be as high as 2.3% (Hatzipantelis et al 2010, Ozer et al 2011, Van Gompel et al 2007 or as low as 0.16% (Coskun et al 2006, Doede et al 2000. The prevalence of aNENs among primary malignant lesions of the appendix ranges between 43 and 57% (Schmutzer et al 1975, Connor et al 1998. Interestingly, in the SEER database, the prevalence of aNENs among all appendiceal neoplasms ranged between 17.3 and 19.7% until 1998(McCusker et al 2002, McGory et al 2005, then were substantially reduced to 9.4% because only 'malignant' neoplasms were included (Hsu et al 2013).…”

Secondary Appendiceal Tumors: A Review of 139 Cases

“…In a review of 8,699 appendectomy specimens by Schmutzer et al, 1 a total of 17 malignancies were identified. They were primary adenocarcinoma (n=2), metastatic adenocarcinoma (n=12), and lymphoma (n=3).…”

“…In a review of 8,699 appendectomy specimens over a 23-year period, no more than 15 cases were identified as SATs. 1 Most SATs have been reported in the form of case reports. The primary sites include the urogenital tract, [2][3][4] gastrointestinal tract, 5,6 breast, 7 and lung.…”

“…One large scale review of appendectomy specimens dates back to the 1970s. 1 Another large scale review of appendectomy specimens only included those from patients that were treated for a clinical diagnosis of appendicitis, with no report of SATs. 9 In addition, there is little data on the clinicopathologic features of patients with SATs.…”