Tumors of specialized gonadal stroma in human male patients.Androblastoma, sertoli cell tumor, granulosa-theca cell tumor of the testis, and gonadal stromal tumor

Mostofi, F. K.; Theiss, Erich A.; Ashley, David J. B.

doi:10.1002/1097-0142(195909/10)12:5<944::aid-cncr2820120515>3.0.co;2-t

Cited by 130 publications

(11 citation statements)

References 22 publications

(1 reference statement)

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“…In the known cases the duration of clinical signs ranged from a few months to 10 years! Nineteen case reports included a follow up: 2 patients died of disease, one of them 11 years after diagnosis [7,17], 3 patients died of unrelated diseases [12,20], 3 patients were alive with disease, one of them 6 years after surgery [16,17,23]. The longest follow-up of one of the 13 patients who were alive without evidence of disease was 14 years [14].…”

Section: Discussionmentioning

confidence: 99%

Adult type granulosa cell tumor of the testis with a heterologous sarcomatous component: case report and review of the literature

et al. 2014

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Adult testicular granulosa cell tumors are rare sex cord- stromal tumors of which only 45 have been previously reported. As compared with their ovarian counterparts, these tumors may follow a more aggressive course because the proportion of malignant cases is higher. We report here a unique case of a 78-year Caucasian with a left sided adult type granulosa cell tumor with a heterologous sarcomatous tumor component. A heterologous sarcomatous component has occasionally been observed in ovarian tumors but never in testicular granulosa cell tumors. The sarcomatous component showed a higher number of mitotic figures (1/Hpf) and a marked proliferation rate (up to 50% Ki 67 positive cells) compared with the granulosa type tumor component. CD 99 and the progesterone receptor were positive in both tumor components, inhibin and calretinin only in the granulosa cells, and pancytokeratin only in the sarcomatouse one. Key words: testis - ovary - granulosa cells - sarcoma - inhibin Runing title: testicular sarcomatous granulosa tumor.Virtual SlidesThe virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/6959043481207016

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Section: Discussionmentioning

confidence: 99%

Adult type granulosa cell tumor of the testis with a heterologous sarcomatous component: case report and review of the literature

et al. 2014

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“…6 The differential diagnosis of adult type GCT includes unclassified sex cord-stromal tumor, lymphoma, metastatic carcinoma with spindle cell differentiation, primary sarcoma, and metastatic melannoma. 7 Ultrasonography can add more information and can be helpful in the differential diagnosis. The neoplasm can appear as a hypoechoic mass with few internal echoes.…”

Section: Discussionmentioning

confidence: 90%

Adult Type Granulosa Cell Tumor of the Testis

Kim

Song

et al. 2008

Korean J Urol

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Testicular granulosa cell tumor (GCT) is a rare neoplasm. We report here on an incidentally discovered testicular granulosa cell tumor in a 36-year-old man. The serum tumor markers were within the normal limits. The ultrasonographic findings revealed a mass with a heterogenous hypoechoic echotexture, including multiple variable sized cystic components. The histology on the orchiectomy specimen demonstrated a gonadal stromal tumor with granulosa cell features. Testicular granulosa cell tumor of the adult type is a very rare tumor, and there have been several isolated case reports and small serial studies described in the literature. CASE REPORTA healthy 35-year-old man presented with a painless right testicular mass started to develop from more than 10 years ago.He denied any past history of trauma, infection, lower urinary tract symptom, surgery, or use of any prescription drug. He was married and had no child. On physical examination, the patient had a 10x8 cm, hard, painless mass and hydrocele on the right testis. The left epididymis and testis were not remarkerble. He had no evidence of gynecomastia or endocrine dysfunction.Serum level of human chorionic gonadotropin, alphafetoprotein, and lactate dehydrogenase were within normal ranges. The scrotal ultrasonography showed a 10x8x7 cm mass with heterogeneous hypoechoic echotexture and multiple variable sized cysts. Doppler color flow within the mass was evident. There was a reactive hydrocele within scrotal sac (Fig. 1). Abdominal CT showed no retroperitoneal lymphadenopathy.Inguinal exploration and radical orchiectomy was performed without complication. The specimen consisted of a right testis measuring 10x8x7 cm with spermatic cord and weighing 378 g in total. Its external surface was covered with tunica vagi-

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“…The great tradition of testicular pathology at the AFIP established in the late 1940s, noted already, continued from the mid‐1950s under the leadership of Dr Fathollah K. Mostofi. Two of the most noteworthy contributions that he and his co‐authors made were an article in the mid‐1950s on sex cord tumours of the testis, and one with Dr John G. Azzopardi as senior author on the remarkable phenomenon of regression of testicular germ cell tumours …”

Section: The Testismentioning

confidence: 99%

“…The great tradition of testicular pathology at the AFIP established in the late 1940s, noted already, continued from the mid-1950s under the leadership of Dr Fathollah K. Mostofi. Two of the most noteworthy contributions that he and his co-authors made were an article in the mid-1950s on sex cord tumours of the testis, 35 and one with Dr John G. Azzopardi as senior author on the remarkable phenomenon of regression of testicular germ cell tumours. 36 The yolk sac tumour is one of the most interesting of all testicular neoplasms, and knowledge about it is, in great part, due to the Danish pathologist Dr Gunnar Teilum (Figure 6), who established its germ cell nature, 37 dating back to his seeing yolk sac tumour (or, as he preferred to call it, endodermal sinus tumour) as a component of mixed germ cell tumours of the testis.…”

Section: The Testismentioning

confidence: 99%

The history of urologic pathology: an overview

Young

Eble

2018

Histopathology

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This article begins with the testis and a legendary figure, Sir Astley Cooper, who wrote an early text on the organ. The early 20th century saw the first major development, the description of the seminoma by the French investigator Maurice Chevassu, but the pace of knowledge did not accelerate until after World War II with a major article from the Armed Forces Institute of Pathology (AFIP) by Nathan B. Friedman and Robert A. Moore, soon followed by the first series testis fascicle by Frank J. Dixon and Moore. Other noteworthy contributions were made by two masters of gonadal pathology, Gunnar Teilum and Robert E. Scully. In the 1970s, Niels E. Skakkebaek played a seminal role in elaborating in‐situ neoplasia of the testis. The school of British testicular tumour authored, in the mid‐1970s, under the editorship of Roger C. B. Pugh, one of the best texts on testicular pathology. Advances in more recent years have been largely spearheaded by Thomas M. Ulbright of the Indiana University School of Medicine. Observations on the prostate gland date back to Andreas Vesalius and William Cheselden, the latter appearing to have introduced the word for the gland. Note is made of contributions on the anatomy and histology of the gland by Oswald Lowsley, L. M. Franks, and John McNeal. Diagnosing carcinoma of the prostate was brought into the modern age in a landmark 1953 article by Robert S. Totten et al. In the 1960s, Donald F. Gleason introduced a grading system that is now in use worldwide. The topic of premalignant lesions has been well established only for approximately three decades, based initially on the work of Dr McNeal and David G. Bostwick. One of the first to write a book on the bladder was the remarkable British surgeon‐pathologist Sir Henry Thompson. Workers at the AFIP, including Colonel James E. Ash and Fatallah K. Mostofi, wrote many outstanding articles on bladder pathology. The roles of other institutions, such as Johns Hopkins University, the Mayo Clinic, and St Peter's Hospital Institute of Urology, London, and those who worked there are noted. Knowledge of the pathology of the urachus dates largely back to the remarkable book on the topic in 1916 by the Hopkins investigator Thomas S. Cullen. Information on renal tumours dates largely to the work of Paul Grawitz, but awareness of the many variants of renal cell carcinoma in general was slow to evolve, and has only accelerated in recent years. The AFIP group of Dr Mostofi, ably assisted by Colonel Charles J. Davis and Isabell A. Sesterhenn, has contributed to knowledge of renal neoplasia with articles of note on oncocytoma, metanephric adenoma, and medullary carcinoma. In the mid‐1980s, the German workers Wolfgang Thoenes and Stephan Störkel recognised the distinctive tumour known as chromophobe renal cell carcinoma. Work on renal tumours in the young owes much to J. Bruce Beckwith. The observational talents of numerous investigators have, in just over a century, advanced our knowledge of diseases of the urinary tract and testis remarkably.

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Tumors of specialized gonadal stroma in human male patients.Androblastoma, sertoli cell tumor, granulosa-theca cell tumor of the testis, and gonadal stromal tumor

Cited by 130 publications

References 22 publications

Adult type granulosa cell tumor of the testis with a heterologous sarcomatous component: case report and review of the literature

Adult type granulosa cell tumor of the testis with a heterologous sarcomatous component: case report and review of the literature

Adult Type Granulosa Cell Tumor of the Testis

The history of urologic pathology: an overview

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