Tumors, Mucus Production, and Hypercoagulability

Pineo, Graham F.; Brain, M. C.; Gallus, Alexander; Hirsh, Jack; Hatton, M. W. C.; Regoeczi, E.

doi:10.1111/j.1749-6632.1974.tb14458.x

Cited by 145 publications

(60 citation statements)

References 16 publications

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“…Thus, the term Trousseau's syndrome is used broadly to refer to any form of excessive coagulation associated with cancers (3). The most commonly associated tumors are mucin-producing adenocarcinomas originating in the lungs, breasts, or alimentary tract (4), which frequently cause microangiopathies induced by hypercoagulability and resultant disseminated intravascular coagulation (5,6). Moreover, the vascular toxicity caused by the chemotherapy may in itself increase the risk of stroke (7).…”

Section: Thrombosis Is One Potential Complication In Patients With Mamentioning

confidence: 99%

Acute Cerebral Infarction during Combination Chemotherapy with S-1 and Cisplatin for a Young Patient with a Mucin-Producing Adenocarcinoma of the Stomach

et al. 2006

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Section: Thrombosis Is One Potential Complication In Patients With Mamentioning

confidence: 99%

Acute Cerebral Infarction during Combination Chemotherapy with S-1 and Cisplatin for a Young Patient with a Mucin-Producing Adenocarcinoma of the Stomach

et al. 2006

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“…Recently, the term has been applied to patients with a known malignancy. The pathogenesis of Trousseau's Syndrome is complex and multi-variable, including intravascular hypercoagulable tumour material [2,3], tumourproducing cytokines [4,5] and external factors.…”

Section: Cinical Imagementioning

confidence: 99%

Trousseau’s Syndrome in Metastatic Vulval Carcinoma

O'Shea¹

2017

Ann Hematol Oncol

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“…Multiple mechanisms of Trousseau's syndrome have also been described [313] . Intravascular coagulation (thrombosis or DIC) has been most frequently associated with mucin-producing adenocarcinomas [314] . Mucins can initiate intravascular coagulation by activating factor X [314] .…”

Section: Trousseau's Syndromementioning

confidence: 99%

“…Intravascular coagulation (thrombosis or DIC) has been most frequently associated with mucin-producing adenocarcinomas [314] . Mucins can initiate intravascular coagulation by activating factor X [314] . Injecting carcinoma mucins into mice generated plateletrich microthrombi dependent on P-and L-selectin, but not thrombin [315] .…”

Section: Trousseau's Syndromementioning

confidence: 99%

Paraneoplastic syndromes associated with lung cancer

1993

Lung Cancer

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Paraneoplastic syndromes are signs or symptoms that occur as a result of organ or tissue damage at locations remote from the site of the primary tumor or metastases. Paraneoplastic syndromes associated with lung cancer can impair various organ functions and include neurologic, endocrine, dermatologic, rheumatologic, hematologic, and ophthalmological syndromes, as well as glomerulopathy and coagulopathy (Trousseau's syndrome). The histological type of lung cancer is generally dependent on the associated syndrome, the two most common of which are humoral hypercalcemia of malignancy in squamous cell carcinoma and the syndrome of inappropriate antidiuretic hormone secretion in small cell lung cancer. The symptoms often precede the diagnosis of the associated lung cancer, especially when the symptoms are neurologic or dermatologic. The proposed mechanisms of paraneoplastic processes include the aberrant release of humoral mediators, such as hormones and hormone-like peptides, cytokines, and antibodies. Treating the underlying cancer is generally the most effective therapy for paraneoplastic syndromes, and treatment soon after symptom onset appears to offer the best potential for symptom improvement. In this article, we review the diagnosis, potential mechanisms, and treatments of a wide variety of paraneoplastic syndromes associated with lung cancer.

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Tumors, Mucus Production, and Hypercoagulability

Cited by 145 publications

References 16 publications

Acute Cerebral Infarction during Combination Chemotherapy with S-1 and Cisplatin for a Young Patient with a Mucin-Producing Adenocarcinoma of the Stomach

Acute Cerebral Infarction during Combination Chemotherapy with S-1 and Cisplatin for a Young Patient with a Mucin-Producing Adenocarcinoma of the Stomach

Trousseau’s Syndrome in Metastatic Vulval Carcinoma

Paraneoplastic syndromes associated with lung cancer

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