Tumors Metastasizing to the Oral Cavity: A Study of 16 Cases

Murillo, Judith; Bagán, José; Hens, E.; Díaz, Juan Sánchez; Leopoldo, Manuel

doi:10.1016/j.joms.2013.03.017

Cited by 45 publications

(58 citation statements)

References 13 publications

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“…The clinical presentation could be deceiving and unusual, therefore, especially in cases with metastasis, searching oral cavity aggressively and performing biopsy is necessary since prognosis is dependent on the extent of metastasis. Mean survival is reported to be poor, which ranged from 7 to 8 months [8, 9]. Treatment strategies are often focused on quality of life, including local resection, radiotherapy as the local treatment and chemotherapy as the systemic treatment for other metastasis [3].…”

Section: Discussionmentioning

confidence: 99%

Gingival Metastasis of ALK Rearranged Non-Small Cell Lung Cancer

2019

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Background: Metastasis to oral soft tissues is rare and account for only 0.1% of all oral malignancies. Oral cavity metastasis tends to be male-predominant, and lung cancer is the leading cause. Targeted therapies for advanced ALK rearranged non-small cell lung cancer (NSCLC) have shown a promising higher response than cytotoxic chemotherapy. Gingival metastasis usually shows poor prognosis. However using ALK inhibitor to ALK-positive advanced NSCLC may show longer survival. Case: A 64-year-old male who was diagnosed non-small cell carcinoma (NSCC) favoring adenocarcinoma presented with gingival metastasis. After first-line chemotherapy, ALK rearrangement was revealed in both primary lesion and gingival metastasis, and therefore the patient was treated with alectinib. Tumor response of the primary site and gingival lesion were obtained, however he presented with intestinal metastasis that lead to bowel obstruction and passed away. Conclusion: Our case showed good response to primary tumor and gingival metastasis but not to intestinal obstruction. ALK inhibitor often shows high response rate and long survival for ALK rearrangement NSCLC, however ALK rearranged positive NSCLC with gingival metastasis may have poor prognosis.

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Section: Discussionmentioning

confidence: 99%

Gingival Metastasis of ALK Rearranged Non-Small Cell Lung Cancer

2019

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“…Twenty-four articles were identified from 1,482 publications [12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31]. The distribution of the 24 publications that entered the final review is as follows: case reports (n: 11), review data from a single institution (n: 11), review data from three institutions (n: 1), systematic reviews or data from multiple institutions (n: 1).…”

Section: Discussionmentioning

confidence: 99%

Unusual Presentation of an Adenocarcinoma of the Lung Metastasizing to the Mandible, Including Molecular Analysis and a Review of the Literature

Gültekin

Şengüven

Gönül

et al. 2016

Journal of Oral and Maxillofacial Surgery

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“…Approximately 1 % of malignant neoplasms of the oral cavity are metastases, and most (64 %) are found in the fifth-to-seventh decade of life, with an associated poor prognosis [7]. They may even constitute the first manifestation of a still unidentified primary malignancy, mainly from the lungs, followed by the prostate, gastrointestinal tract, thyroid gland, breast, skin, and liver [8]. There is a clear male predominance, with a mixed presentation of soft tissue and bone involvement, especially in the mandible [7,8].…”

Section: Discussionmentioning

confidence: 99%

“…They may even constitute the first manifestation of a still unidentified primary malignancy, mainly from the lungs, followed by the prostate, gastrointestinal tract, thyroid gland, breast, skin, and liver [8]. There is a clear male predominance, with a mixed presentation of soft tissue and bone involvement, especially in the mandible [7,8]. Gingiva and alveolar mucosa have been described as the most common oral sites (54.8 %), with a misleading resemblance to hyperplastic or inflammatory reactions [7].…”

Section: Discussionmentioning

confidence: 99%

Salivary mucinous adenocarcinoma of the mandible

et al. 2016

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Mucinous adenocarcinoma (MAC) is a malignancy rarely affecting the salivary glands, with fewer than 30 cases described in the medical literature. MAC is mostly observed in the minor salivary glands of the palate, and to date, no case of salivary MAC has been reported in the mandible. Identifying a salivary MAC may be both clinically and histopathologically challenging, as differential diagnosis must consider not only other salivary malignancies expressing a mucinous component but also metastases from MACs of the gastrointestinal tract, breast, and sweat glands that strongly resemble a salivary MAC on histopathology. We describe an 80-year-old man with a gingival overgrowth of the left mandible for the past 9 months, who was referred to our institution with an initial diagnosis of a periodontal reaction. On clinical examination, the mass mimicked a hyperplastic lesion; but after biopsy, the histopathologic pattern suggested a diagnosis of MAC. Herein, we present how comprehensive physical examination of the patient, immunohistochemistry study of the specimen, and radiological features helped in establishing the diagnosis of intraosseous salivary MAC, ruling out metastatic disease or other salivary neoplasms.

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Tumors Metastasizing to the Oral Cavity: A Study of 16 Cases

Cited by 45 publications

References 13 publications

Gingival Metastasis of ALK Rearranged Non-Small Cell Lung Cancer

Gingival Metastasis of ALK Rearranged Non-Small Cell Lung Cancer

Unusual Presentation of an Adenocarcinoma of the Lung Metastasizing to the Mandible, Including Molecular Analysis and a Review of the Literature

Salivary mucinous adenocarcinoma of the mandible

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