Tumors Involving Bone in the Domestic Cat: A Review of Fifty-eight Cases

Quigley, P. J.; Leedale, A. H.

doi:10.1177/030098588302000603

Cited by 87 publications

(70 citation statements)

References 12 publications

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“…organs (1, 4,5,7,9,10,11,12,13). Such metastases seem to occur frequently, as seen in our postmortem material and from a preliminary retrospective study of carcinomas in the skin in cats, where many had the features of metastatic carcinomas of pulmonary origin (own data, not shown).…”

Section: Discussionsupporting

confidence: 69%

Primary and metastatic carcinomas in the digits of cats

Linde‐Sipman

Ingh

2000

Veterinary Quarterly

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In the period 1993-1998, digital carcinomas in 64 cats were examined. In all animals primary complaints were painful digit(s). Eight cats had a primary squamous cell carcinoma which involved one digit or two adjacent digits of one leg. Fifty-six cats had metastases of a pulmonary carcinoma in the digits, and in general multiple digits of different legs were involved. In many of these cats metastases also occurred in other organs, including the skin and muscles. No primary sweat gland carcinomas of the digits were seen. Primary squamous cell carcinomas of the digits were characterized by cornification and the absence of PAS-positive cells, PAS-positive secretory material. Immunohistochemically, these neoplasms stained negative with the monoclonal antibody CAM 5.2 directed against Keratin 8 (K 8). The metastases of pulmonary carcinomas to the digits showed one or more of the following histological features: goblet cells, ciliated epithelial cells, PAS-positive cells or lakes, and/or a PAS-positive lining of luminal membranes and no cornification. Immunohistochemically, they showed positive staining for CAM 5.2 (K8). Thoracic radiographs from three cats with a primary squamous cell carcinoma showed no abnormalities, whereas all cases of metastases from a pulmonary carcinoma to the digits available for follow-up showed evidence of a primary pulmonary carcinoma on radiography and/or postmortem examination (25 out of 56). The conclusion of this study was that most carcinomas in the digits of cats were metastases of a primary pulmonary carcinoma (87.5%). Primary squamous cell carcinomas occurred infrequently. The prognosis of metastases of a pulmonary carcinoma in the digits is poor with an average survival time of 4.9 weeks, in contrast to 29.5 weeks in cats with a squamous cell carcinoma. These data stress the importance of taking thoracic radiographs of cats with digital tumours before surgical intervention.

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Section: Discussionsupporting

confidence: 69%

Primary and metastatic carcinomas in the digits of cats

Linde‐Sipman

Ingh

2000

Veterinary Quarterly

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“…In human cancer patients, a standard intravenous dose of 1 mg/kg results in a peak plasma concentration of 9.7 μ M. The dose used in our patients was extrapolated from that published in people, dogs, and cats (1-2 mg/kg) [13, 15, 18–20, 25]. In this study of neoplastic feline cell lines with bone-invasive potential [3, 4], pamidronate demonstrated direct in vitro anticancer activity. Feline cells (SCC and FSA) demonstrate comparable sensitivity to canine OSA cell lines [22, 23] with antiproliferative effects within the putative achievable serum concentration (9.7 μ M).…”

Section: Discussionmentioning

confidence: 99%

“…In addition to the tumors treated here, (OSCC, aural SCC, osteosarcoma and rib metastasis of pulmonary carcinoma), other tumor histologies with bone-invasive potential that may benefit include soft tissue sarcomas such as vaccine-associated sarcomas and fibrosarcoma, multiple myeloma, and tumors of the orbit, digit, ear canal, vertebra, and sinonasal cavity. [4, 35–45]. Caution should be taken when administering pamidronate with preexisting renal disease or in conjunction with other potentially nephrotoxic drugs.…”

Section: Discussionmentioning

confidence: 99%

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Pamidronate Disodium for Palliative Therapy of Feline Bone-Invasive Tumors

Wypij

Heller²

2014

Veterinary Medicine International

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This study sought to quantify in vitro antiproliferative effects of pamidronate in feline cancer cells and assess feasibility of use of pamidronate in cats by assessing short-term toxicity and dosing schedule in cats with bone-invasive cancer. A retrospective pilot study included eight cats with bone invasive cancer treated with intravenous pamidronate. In vitro, pamidronate reduced proliferation in feline cancer cells (P < 0.05). One cat treated with pamidronate in combination with chemotherapy and two cats treated with pamidronate as a single agent after failing prior therapy had subjective clinically stable disease; median progression free interval in these cats from initial pamidronate treatment was 81 days. Three cats developed azotemia while undergoing various treatment modalities including nonsteroidal anti-inflammatory drugs and pamidronate. Median overall survival was 116.5 days for all cats and 170 days for cats with oral squamous cell carcinoma. Median progression free survival was 55 days for all cats and 71 days for cats with oral squamous cell carcinoma. Pamidronate therapy appears feasible for administration in cancer bearing cats with aggressive bone lesions in the dose range of 1-2 mg/kg every 21–28 days for multiple treatments. No acute or short-term toxicity was directly attributable to pamidronate.

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“…Ameloblastic odontoma has been reported in a variety of mammalian species, including dog (5), cat (6), cow (7), sheep (8), llama (9), non-human primate (10,11), and rat (2,12,13). …”

Section: Introductionmentioning

confidence: 99%

Spontaneous Peripheral Ameloblastic Odontoma in a Male Sprague-Dawley Rat

Li¹,

Bae

Kim³

et al. 2017

ToxicolRes

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Peripheral ameloblastic odontoma is a rare variant of odontogenic tumor occurring in the extraosseous region. The present report describes a spontaneous tumor in male Sprague-Dawley (SD) rats. The clinically confirmed nodule in the right mandibular region was first observed when the rat was 42 weeks and remained until the terminal sacrifice date when the animal was 48 weeks of age. At necropsy, a well demarcated nodule, approximately 2.5 × 2.0 × 2.0 cm, protruded from the ventral area of the right mandible. The nodule was not attached to mandibular bone and was not continuous with the normal teeth. Histopathologically, the tumor was characterized by the simultaneous occurrence of an ameloblastomatous component and composite odontoma-like elements within the same tumor. The epithelial portion formed islands or cords resembling the follicle or plexiform pattern typical of ameloblastoma and was surrounded by mesenchymal tissue. Formation of eosinophilic and basophilic hard tissue matrix (dentin and enamel) resembling odontoma was observed in the center of the tumor. Mitotic figures were rare, and areas of cystic degeneration were present. Immunohistochemically, the epithelial component was positive for cytokeratin AE1/AE3 (CK AE1/AE3), and the mesenchymal component and odontoblast-like cells were positive for vimentin, in the same manner as in normal teeth. On the basis of these findings, the tumor was diagnosed as a peripheral ameloblastic odontoma in an extraosseous mandibular region in a SD rat. In the present study, we report the uncommon spontaneous peripheral ameloblastic odontoma in the SD rat. We also discuss here the morphological characteristics, origin, histochemical, and immunohistochemical features for the diagnosis of this tumor.

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Tumors Involving Bone in the Domestic Cat: A Review of Fifty-eight Cases

Cited by 87 publications

References 12 publications

Primary and metastatic carcinomas in the digits of cats

Primary and metastatic carcinomas in the digits of cats

Pamidronate Disodium for Palliative Therapy of Feline Bone-Invasive Tumors

Spontaneous Peripheral Ameloblastic Odontoma in a Male Sprague-Dawley Rat

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