Tumors in the parotid are not relatively more often malignant in children than in adults

Stevens, Elizabeth M.; Andreasen, Simon; Bjørndal, Kristine; Homøe, Preben

doi:10.1016/j.ijporl.2015.04.035

Cited by 20 publications

(19 citation statements)

References 22 publications

(69 reference statements)

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“…The study reported a total of nine cases of salivary gland cancer with patients ranging from the age of 11–17 years. Of the nine cases, five children were 14 years or less, and of these the most frequent histological type was mucoepidermoid carcinoma, as described by our study . Fortunately, pediatric salivary gland tumors often have a favorable prognosis as they are typically identified at an early stage and are most often low grade .…”

Section: Discussionsupporting

confidence: 56%

“…Of the nine cases, five children were 14 years or less, and of these the most frequent histological type was mucoepidermoid carcinoma, as described by our study. 28 Fortunately, pediatric salivary gland tumors often have a favorable prognosis as they are typically identified at an early stage and are most often low grade. 29 Interestingly, the incidence of salivary gland cancer among children and adults has remained stable in Denmark from 1990…”

Section: Trends In the Incidence Of Pediatric Hnc Stratified By Tumormentioning

confidence: 99%

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Incidence of head and neck cancer in children: A Danish nationwide study from 1978 to 2014

Larsen

Hjalgrim

Jakobsen

et al. 2018

Pediatric Blood & Cancer

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Section: Discussionsupporting

confidence: 56%

Section: Trends In the Incidence Of Pediatric Hnc Stratified By Tumormentioning

confidence: 99%

Incidence of head and neck cancer in children: A Danish nationwide study from 1978 to 2014

Larsen

Hjalgrim

Jakobsen

et al. 2018

Pediatric Blood & Cancer

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“…However, the Danish nationwide survey reported incidences of 0.12 and 0.53 per 100,000 children for malignant and benign ESGNs, respectively [4] . Most malignant salivary gland tumours present in the older child, with an average age of 13.5 years at diagnosis, whereas benign neoplasms present at a slightly older age, or 15 years, with an equal sex distribution [6] .…”

Section: Malignantmentioning

confidence: 99%

“…When a solitary SGN is present, the chance of malignancy is greater in a child than in an adult [1][2][3] . The concept that paediatric SGNs are more likely malignant than adult SGNs has been challenged by suggestions that previous data have been 'selected material' and by reporting of a nationwide survey from Denmark over a 16-year period (1990-2005) [4] . The survey identified 61 patients, in whom 85% of the tumours were benign, and the parotid gland was involved in the 9 cases of malignancy.…”

Section: Introductionmentioning

confidence: 99%

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Salivary Gland Neoplasms in Children and Adolescents

Bradley

Eisele

2016

Salivary Gland Neoplasms

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Salivary gland neoplasms (SGNs) in children are uncommon. Epithelial SGNs (ESGNs) comprise the majority (95%), with the remaining being mesenchymal SGNs (MeSGNs). Pleomorphic adenoma is the most frequently encountered benign neoplasm, mucoepidermoid carcinoma is the most frequent malignant ESGN, and rhabdomyosarcoma is the most frequent malignant MeSGN. ESGN presents in the second decade, whereas MeSGN presents in the first and second decades. Swelling without pain or neurological signs is the main presentation of both benign and malignant neoplasms. Making an accurate preoperative histological diagnosis is important, so a needle biopsy or a perioperative frozen section is useful when there is doubt about the disease status of the patient; the excised tumour margin is also important. Surgical excision should aim to achieve clear margin excision in benign and malignant ESGNs, minimising the need for adjuvant radiotherapy and maximising the long-term likelihood of patient cure. Benign ESGNs are uncommon, and excision is curative, whereas malignant ESGN and MeSGN should be managed by a multidisciplinary paediatric oncology team.

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Pleomorphic adenoma of the head and neck in children: presentation and management

et al. 2018

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Objective: Pleomorphic adenoma is the most common benign salivary gland neoplasm in children. Recurrence and malignant transformation are concerns necessitating proper treatment. The goal of this research was to discuss the presentation, evaluation, and management of pediatric pleomorphic adenoma of the head and neck.Methods: Retrospective chart review of patients under 20 years of age treated for pleomorphic adenoma of the head and neck between 1998 and 2017. Data assessed included demographics, clinical presentation, imaging, treatment, complications, recurrence, and follow-up.Results: Forty-one patients with pleomorphic adenoma were identified. Major salivary gland lesions were most common (n = 32, 78.0%); 78.1% (25 of 32) arising in the parotid and 21.9% (7 of 32) in the submandibular glands. Minor salivary gland lesions were removed from the palate (5 of 9, 55.6%), buccal mucosa (2 of 9, 22.2%), parapharyngeal space (1 of 9, 11.1%), and upper lip (1 of 9, 11.1%). Preoperative imaging was reviewed in 32 patients and consisted of nine ultrasound exams, 15 computerized tomography (CT) exams, and 23 magnetic resonance imaging (MRI) exams. Multimodality imaging was performed in 14 of 32 patients. Surgical excision was performed in all patients. Postoperative complications included transient facial paresis (n = 9), Frey syndrome (n = 1), and bacterial pharyngitis (n = 1). Average length of follow-up was 25.5 months; confirmed recurrence occurred in two patients (4.9%).Conclusion: Evaluation of pleomorphic adenoma in children should include preoperative imaging. The goal of surgery should be complete surgical excision with negative margins. Rate of recurrence is low; however, prolonged monitoring is recommended.

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Tumors in the parotid are not relatively more often malignant in children than in adults

Cited by 20 publications

References 22 publications

Incidence of head and neck cancer in children: A Danish nationwide study from 1978 to 2014

Incidence of head and neck cancer in children: A Danish nationwide study from 1978 to 2014

Salivary Gland Neoplasms in Children and Adolescents

Pleomorphic adenoma of the head and neck in children: presentation and management

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