Tumors in long-term rat studies associated with microchip animal identification devices

Elcock, Laura E.; Stuart, Barry P.; Wahle, B.S.; Hoss, H.; Crabb, Kerry; Millard, Donna M.; Mueller, Robert E.; Hastings, Thomas F.; Lake, Stephen G.

doi:10.1016/s0940-2993(01)80002-6

Cited by 59 publications

(46 citation statements)

References 10 publications

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“…The majority of transponderassociated tumors have been mesenchymal in origin, and the mechanism of carcinogenicity is thought to be foreign bodyinduced tumorigenesis (Brand et al 1976;Elcock et al 2001). …”

Section: Resultsmentioning

confidence: 99%

Peritoneal Sarcomatosis Associated with Telemetry Implants in Sprague Dawley CD Rats

et al. 2011

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Surgical implantation of radiotelemetric transmitters is a current practice to collect a variety of physiological parameters in unrestrained laboratory animals, and in rodents in particular. In this study, the incidence of peritoneal sarcomatosis arising secondary to surgically implanted telemetry devices (< 15% of implanted Sprague Dawley rats) is considered to represent a significant issue for both animal welfare and data validity in affected animals. Macroscopically, the telemetry-associated fibrosarcomas spread along the visceral and parietal peritoneum and mesentery surrounding abdominal organs. The histologic morphology of these sarcomas was typically an undifferentiated sarcoma, although well-differentiated fibrosarcomas and telangiectatic and pleomorphic variants were noted. Using special stains such as Masson's Trichrome demonstrated a collagenous extracellular matrix in 50% of these rats, which is consistent with a fibroblastic origin. Immunohistochemical studies clearly delineated the mesenchymal components of the sarcomas (fibroblasts and smooth muscle cells); one case, however, was diagnosed as an osteosarcoma.

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Section: Resultsmentioning

confidence: 99%

Peritoneal Sarcomatosis Associated with Telemetry Implants in Sprague Dawley CD Rats

et al. 2011

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“…The fibrosarcomas in this study were predominately at the site of implantation in both the placebo (2 females) and the control rats (one male). Fibrosarcomas have also been associated with microchip identification devices in rats [51] and injections/vaccines and microchips in both cats and dogs [52,53]. The relative increase in the presence of fibrosarcomas in this study (5.6%), as compared with historical controls (up to 3.2%), may be due to the minor damage and associated inflammatory and reparative responses that occurred during the implant procedure.…”

Section: Discussionmentioning

confidence: 55%

The Occurrence of Spontaneous Lymphomas but Not Adenomas or Sarcomas in Rats Treated With Sustained Release Naltrexone

Kelty¹

2012

Clin Exp Pharmacol

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Naltrexone has been observed to have both a stimulatory and inhibitory effect on the development of tumours in rodents, potentially mediated by changes to the neuroendocrine system as a result of blockade of the opiate receptors, with the period of blockade and the tumour type thought to be influential. This study examined the occurrence of spontaneous tumours in rats treated with a sustained release naltrexone preparation. Materials and methods: 27 male and 27 female rats were randomized into three equal treatment groups (A, B and C). Rats in group A were implanted with a single naltrexone implant tablet, rats in group B were implanted with a single polymer implant tablet (placebo) and rats in group C underwent a sham procedure (control). Three different groups of spontaneous tumours were observed; lymphomas, adenomas and sarcomas. Lymphomas (4 tumours/3 rats) were observed solely in naltrexone treated rats, while adenomas (9 tumours/5 rats) and sarcomas (4 tumours/3 rats) were only observed in the placebo and the control groups. The data suggests that the association of naltrexone on the development of tumours maybe dependent on tumour type. Long term exposure to naltrexone appears to have both a stimulatory and inhibitory effect on tumours in rats, dependent on tumour type.

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“…These include migration, infection, neoplastic growth reaction, failure to work or loss from the body (Rao & Edmonson 1990, Burk & Eich 1995, Swift 2000, Elcock et al 2001, Swift 2002, Le Calvez et al 2006, Vascellari et al 2006. To minimize the risk of adverse reactions in the fetus, it is important to follow the manufacturers' instructions and to fix the animal so the thigh muscle is accessible without harming the fetus.…”

Section: Discussionmentioning

confidence: 99%

“…The microchip is hermetically encapsulated within a smooth and strong biocompatible glass and is small enough to fit into a 12G hypodermic needle. The capsule is about the size of a grain of rice (12 mm long and 2 mm in diameter) and a 5 mm long part of the body is covered by a porous polypropylene polymer sheath as an antimigration measure (Rao & Edmondson 1990, Ball et al 1991, Elcock et al 2001, Le Calvez et al 2006. This polypropylene cap causes development of a thin coherent membrane consisting of fibrocytes and collagen fibres thereby fixing the microchip (Rao & Edmondson 1990).…”

mentioning

confidence: 99%

A novel method for transuterine identification of piglets

Birck¹,

Iburg²,

Schmidt³

et al. 2008

Lab Anim

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SummaryImplantable microchips provide a secure, permanent and unique identification of individual animals. When performing fetal intervention studies in experimental animal models easy and secure identification of fetuses is desirable, as having test and control groups within the same uterus reduces the total number of animals used in a study. The aims of this study were: (1) to establish a protocol to identify porcine fetuses in utero by microchip implantation and (2) to assess postnatally whether clinical or pathological reactions to the implant occurred. Two Danish Landrace/Danish Large White crossbred sows at day 100 of gestation were used. The sows were sedated with azaperone and induced with propofol intravenously. Anaesthesia was maintained with isoflurane and oxygen. Antibiotics were administered intramuscularly (i.m.) at induction and analgesia was given pre-, intra-and postoperatively. A laparotomy was performed and the uterus exteriorized. The rump of the first fetus was recognized through the uterine wall and the thigh muscle of the fetus was fixed between the thumb and the forefinger. The microchip was then implanted into the fetus at an angle of 458 i.m. in the lateral hindleg using an insertion device with a 12G needle. The same procedure was done in every fetus. The uterus was returned to the abdomen and the abdominal wall closed. The sows gave birth to 24 liveborn piglets and one stillborn. None of the liveborn piglets were limping at the time of birth and no visible cutaneous or palpable reactions on the hindlegs were observed. Following euthanasia, the microchip was easily localized and no macroscopic reactions at the implantation site were seen. None of the piglets had more than one microchip implanted. Histology showed a chronic mild foreign body granulomatous inflammatory response with peripheral eosinophils surrounding the microchip. No inflammation was evident in the adjacent muscles. It is concluded that transuterine identification of piglets two weeks before delivery is feasible using a microchip implant as an effective, easy and reliable method for identification of individuals after birth.

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Tumors in long-term rat studies associated with microchip animal identification devices

Cited by 59 publications

References 10 publications

Peritoneal Sarcomatosis Associated with Telemetry Implants in Sprague Dawley CD Rats

Peritoneal Sarcomatosis Associated with Telemetry Implants in Sprague Dawley CD Rats

The Occurrence of Spontaneous Lymphomas but Not Adenomas or Sarcomas in Rats Treated With Sustained Release Naltrexone

A novel method for transuterine identification of piglets

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