Tumors and Fibrinogen

Simpson-Haidaris, Patricia J.; Rybarczyk, Brian J.

doi:10.1111/j.1749-6632.2001.tb03525.x

Cited by 247 publications

(57 citation statements)

References 76 publications

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“…Fibrinogen plays critical role in angiogenesis, tumor cell growth, proliferation and development by sequestering the growth factors like fibroblast growth factor-2 and vascular endothelial growth factor 39, 40 . Tumor cells utilize sequestered growth factors by degrading the fibrinogen 41 .…”

Section: Discussionmentioning

confidence: 99%

Subventricular zone involvement in Glioblastoma – A proteomic evaluation and clinicoradiological correlation

Gollapalli

Ghantasala

Kumar

et al. 2017

Sci Rep

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Glioblastoma multiforme (GBM), the most malignant of all gliomas is characterized by a high degree of heterogeneity and poor response to treatment. The sub-ventricular zone (SVZ) is the major site of neurogenesis in the brain and is rich in neural stem cells. Based on the proximity of the GBM tumors to the SVZ, the tumors can be further classified into SVZ+ and SVZ−. The tumors located in close contact with the SVZ are classified as SVZ+, while the tumors located distantly from the SVZ are classified as SVZ−. To gain an insight into the increased aggressiveness of SVZ+ over SVZ− tumors, we have used proteomics techniques like 2D-DIGE and LC-MS/MS to investigate any possible proteomic differences between the two subtypes. Serum proteomic analysis revealed significant alterations of various acute phase proteins and lipid carrying proteins, while tissue proteomic analysis revealed significant alterations in cytoskeletal, lipid binding, chaperone and cell cycle regulating proteins, which are already known to be associated with disease pathobiology. These findings provide cues to molecular basis behind increased aggressiveness of SVZ+ GBM tumors over SVZ− GBM tumors and plausible therapeutic targets to improve treatment modalities for these highly invasive tumors.

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Section: Discussionmentioning

confidence: 99%

Subventricular zone involvement in Glioblastoma – A proteomic evaluation and clinicoradiological correlation

Gollapalli

Ghantasala

Kumar

et al. 2017

Sci Rep

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“…As a major acute-phase protein, elevated levels of fibrinogen may be induced by an inflammatory reaction to tumour growth and a prothrombotic state in cancer patients [5,23,24]. Other studies show that fibrinogen can be endogenously synthesised by tumour cells themselves [7,25]. In tumourigenesis, fibrinogen is a multifunctional protein that influences many cellular processes.…”

Section: Discussionmentioning

confidence: 99%

“…In tumourigenesis, fibrinogen is a multifunctional protein that influences many cellular processes. During the formation of the tumour stroma, fibrinogen is embedded in the extracellular matrix and serves as a scaffold to combine growth factors with tumour cells, thereby providing structure to the tumour stroma and regulating invasive potential and malignant transformation [7,26,27]. Through interactions with fibroblast growth factor-2 (FGF-2) and vascular endothelial growth factor (VEGF), fibrinogen can for example regulate cellular adhesion, proliferation, and migration [25,28].…”

Section: Discussionmentioning

confidence: 99%

“…Fibrinogen and platelets, which are essential coagulation parameters during the coagulation cascade, are also closely linked to several pathophysiological processes, such as cell adhesion, inflammatory processes, and wound healing. In recent years, a substantial number of studies have supported the hypothesis that fibrinogen and platelets play vital roles in tumourigenesis, contributing to angiogenesis, stroma formation, and haematogenous metastasis of tumour cells [7,8,9,10]. In clinical studies, Polterauer et al [11] demonstrated that the pretreatment plasma fibrinogen level was an independent prognostic parameter for stage I-IV cervical cancer.…”

Section: Introductionmentioning

confidence: 99%

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Prognostic Significance of Pretreatment Plasma Fibrinogen and Platelet Levels in Patients with Early-Stage Cervical Cancer

Zhao

Deng²,

Qin

et al. 2014

Gynecol Obstet Invest

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Background: Hyperfibrinogenaemia and thrombocytosis, which usually occur in cancer patients, have been shown to contribute to cancer cell growth, progression, and metastasis. The aims of the present study were to assess the prognostic significance of pretreatment plasma fibrinogen and platelet levels in early-stage cervical cancer patients. Methods: The present study was a retrospective analysis of 220 cervical cancer patients with stage I-IIA disease. The pretreatment plasma fibrinogen and platelet levels were investigated along with clinicopathological findings and survival data. Results: The incidences of hyperfibrinogenaemia and thrombocytosis were 11.8 and 25.5%, respectively. Elevated fibrinogen levels were associated with advanced tumour stage, older age, large tumour size, deep stromal invasion, and tumour recurrence, whereas higher platelet levels correlated significantly with advanced tumour stage, large tumour size, and tumour recurrence. Kaplan-Meier analysis showed that hyperfibrinogenaemia and thrombocytosis were significantly associated with shorter disease-free and overall survival. Furthermore, patients with hyperfibrinogenaemia and thrombocytosis may suffer from a higher risk of recurrence. Multivariate survival analyses showed that fibrinogen levels, but not platelet levels, were an independent prognostic factor for poor survival in early-stage patients. Conclusion: Hyperfibrinogenaemia and thrombocytosis may be valuable biomarkers for predicting recurrence in patients with early-stage cervical cancer.

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“…Fibrinogen promotes the cellular response to adhesion, proliferation and migration during angiogenesis and tumour cell growth [36]. Human breast cancer cells synthesize and secrete fibrinogen polypeptides [36,37].…”

Section: Discussionmentioning

confidence: 99%

Proteomics of Grade 3 infiltrating ductal carcinoma in Malaysian Chinese breast cancer patients

Othman

Majid

Singh³

et al. 2009

Biotech and App Biochem

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Breast cancer is the leading cause of cancer-related mortality and morbidity among women worldwide and IDC (infiltrating ductal carcinoma) is the most common type of invasive breast cancer. The changes in the biological behaviour of cancer tissue can be predicted by measuring the differential protein expression of normal and cancerous tissues. Using a combination of SDS/PAGE and LC (liquid chromatography)-MS/MS (tandem MS), we identified 82 common and differentially expressed proteins from normal and cancerous breast tissues in 20 Malaysian Chinese patients with IDC. These proteins are extracted from the normal and cancerous tissue of patients and therefore represent the actual proteins involved in cancer development. Proteins identified possibly have significant roles in the development of breast cancer in Malaysian Chinese patients in view of their consistent expression in most of the patients, although some of the proteins had not been detected in earlier studies that were mostly carried out in Western countries. This observation suggests that molecular mechanisms leading to breast cancer development in this region may not be identical with those leading to IDC in Western regions.

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Tumors and Fibrinogen

Cited by 247 publications

References 76 publications

Subventricular zone involvement in Glioblastoma – A proteomic evaluation and clinicoradiological correlation

Subventricular zone involvement in Glioblastoma – A proteomic evaluation and clinicoradiological correlation

Prognostic Significance of Pretreatment Plasma Fibrinogen and Platelet Levels in Patients with Early-Stage Cervical Cancer

Proteomics of Grade 3 infiltrating ductal carcinoma in Malaysian Chinese breast cancer patients

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