Tumorigenic PVT‐1 gene locus is governed by miR‐2909 RNomics

Abstract

Genomic regulation and functional significance of PVT‐1 gene locus, in the MYC‐driven cancers, has remained enigmatic ever since its discovery. With the present study, an attempt is made to establish that cellular AATF genome encoded miR‐2909 RNomics pathway involving crucial genes coding for KLF4, Deptor, mTORC1, STAT3, and p53 has the inherent capacity to ensure sustained co‐amplification of PVT‐1 gene locus together with c‐Myc gene. Based upon these results, we propose that miR‐2909 RNomics pathway may play a crucial role in the regulation of tumorigenic PVT‐1 gene locus.