Tumores neuroendocrinos no funcionantes de páncreas incidentales de pequeño tamaño: Resultados de una serie con manejo no quirúrgico

Galeano, Catalina Uribe; Prous, Joan Fabregat; Busquets, Juli; Serra, Núria; Medayo, Lluis Secanella; Ramos, Emilio; Osuna, Sandra Ruiz; Artero, Carles Villabona

doi:10.1016/j.ciresp.2016.12.006

Cited by 6 publications

(4 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…A message to point out in these cases subjected to expectant conduct is related to the necessity of a strict monitoring of patients through imaging examination every 3 months during the first year of follow-up, followed by every 6 months during the next 3 years. Furthermore, upon any signs of tumor growth or malignancy, the treatment must be switched immediately to surgical resection [ 7 , 21 ]. However, small tumors can be malignant at presentation, as shown in this study, suggesting that surgical resection is still the best approach.…”

Section: Discussionmentioning

confidence: 99%

Insights of Outcome after Resection of Small Nonfunctioning Neuroendocrine Pancreatic Tumors

Figueira

Ribeiro

et al. 2021

Gastroenterology Research and Practice

View full text Add to dashboard Cite

Background. The incidence of small nonfunctioning neuroendocrine pancreatic tumors (NF-PNETs) has been increasing systematically in the last few decades. Surgical resection was once considered the treatment of choice but has been questioned in the direction of a more conservative approach for selected patients. Our aim was to analyze the outcome of surgical resection of small (≤3cm) NF-PNETs. Methods. We retrospectively evaluated 14 patients with sporadic NF-PNETs who underwent pancreatic resection. Data were collected from patients’ medical records. Results. Of the 14 patients included, 35.71% were men, and the average age was 52.36 ± 20.36 years. Comorbidities were present in 92.86% of the cases. The incidence of postoperative complications was 42.86%, the 30-day mortality was zero, and the length of follow-up was 3.31 ± 3.0 years. The results of pathological evaluations revealed WHO grade I in 42.86% of cases, II in 21.43%, and neuroendocrine carcinoma in 35.71%. The median tumor size was 1.85cm (range, 0.5–3cm), and 2 cases had synchronous metastasis. The median TNM stage was IIa (range, I–IV). The disease-free and patient survival rates were 87.5% and 100% at 3 years and 43.75% and 75% at 10 years, respectively. The tumor pathological grade was significantly higher in head tumors than body-tail tumors, but there were no differences with respect to tumor size and TNM staging. Conclusion. A surgical approach to treat small sporadic NF-PNETs is safe with low mortality and high patient survival. Based on these data, small pancreatic head tumors can be more aggressive, suggesting that surgical resection is still the best option to treat small nonfunctioning PNETS. Thus, conservative treatment should be indicated very cautiously for only cases with absolute contraindications for surgery.

show abstract

Section: Discussionmentioning

confidence: 99%

Insights of Outcome after Resection of Small Nonfunctioning Neuroendocrine Pancreatic Tumors

Figueira

Ribeiro

et al. 2021

Gastroenterology Research and Practice

View full text Add to dashboard Cite

show abstract

“…The reported incidence of feline primary pancreatic neoplasia is extremely low and reports on pancreatic neuroendocrine neoplasia (pan-NEN), other than insulinomas, are even more rare, although the true incidence of pan-NEN might be higher than assumed (Seaman, 2004;Linderman et al, 2013). In general, pan-NENs are divided into two groups: functional (hormone-producing and -secreting) and nonfunctional neoplasms (Uribe Galeano et al, 2017). As in humans (Halfdanarson et al, 2008), most are non-functional, eventually producing hormones, but without inducing clinically evident hormone-related syndromes (Seaman, 2004;Linderman et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

Development of a non-functional pancreatic neuroendocrine tumor and a duodenal ulceration after cholecystoduodenostomy in a cat

Bianchini¹,

Devriendt²,

Cock³

et al. 2020

VDT

View full text Add to dashboard Cite

A six-year-old Ragdoll with previous extrahepatic biliary tract obstruction due to cholangiohepatitis, treated with cholecystoduodenostomy, was presented for acute vomiting, hyporexia, and weight loss. Abdominal ultrasound examination revealed randomly distributed hepatic nodules and dilated biliary ducts. Gastroduodenoscopy showed a patent cholecystoduodenostoma but disclosed a perforated duodenal ulceration. Conversion to celiotomy revealed extensive liver pathology, a discrete pancreatic nodule, and a duodenal ulcer opposite to the cholecystoduodenostoma. The cat was euthanized intra-operatively and necropsy was performed. The intrahepatic biliary tract of the right liver lobes was obstructed and severely dilated, whereas bile from the left lobes drained through the cholecystoduodenostoma. Histopathologic diagnoses were a primary pancreatic tumor, positive for glucagon on immunohistochemistry, with liver metastases, chronic purulent cholecystitis, and duodenal ulceration. To the authors’ knowledge, this is the first report in which the development of pancreatic neoplasia is described in a cat with a history of biliary tract disease.

show abstract

“…Se distingue entre técnicas ahorradoras de parénquima (enucleación, pancreatectomía central), como ocurrió en cuatro de nuestros pacientes, y técnicas de pancreatectomía regladas (duodenopancreatectomía cefálica, pancreatectomía corporocaudal), como se llevó a cabo en otros cuatro 3,5 . En recientes guías clínicas también se acepta el tratamiento conservador con control evolutivo, mediante pruebas de imagen, de tumores seleccionados (no funcionantes, menores de 1-2 cm, bien diferenciados, localizados en cabeza-cuello del páncreas), como fue el caso de uno de nuestros pacientes, que se trataba de un síndrome de MEN1 con TNEp de localización múltiple 3 . En los casos de enfermedad avanzada está indicado el tratamiento quirúrgico de las metástasis 5 .…”

Section: B Aunclassified

“…Pueden aparecer de manera esporádica o asociados a síndromes genéticos 1,2 . Los TNEp se dividen en funcionantes y no funcionantes 3 . Clásicamente, este tipo de lesiones se diagnosticaban a raíz del síndrome clínico producido por la hipersecreción hormonal, pero en las últimas décadas se ha incrementado el diagnóstico de TNEp no funcionantes y en la actualidad son el tipo más frecuente.…”

Section: Introductionunclassified

Tumores neuroendocrinos pancreáticos. Nuestra experiencia

Sánchez-Cifuentes¹,

Candel-Arenas²,

Luján-Martínez³

et al. 2018

CIRU

View full text Add to dashboard Cite

Los tumores neuroendocrinos pancreáticos son poco frecuentes. Es un grupo heterogéneo de neoplasias con comportamiento y pronóstico muy diferentes. Pueden aparecer de manera esporádica o asociados a síndromes genéticos. Se dividen en funcionantes y no funcionantes. Se realizó un estudio retrospectivo descriptivo de los pacientes diagnosticados de tumor neuroendocrino pancreático. Como se refleja en nuestra serie, cada vez es más frecuente el diagnostico incidental de estos tumores. El único tratamiento curativo de estos tumores es la exéresis quirúrgica, según la localización y las características del tumor y del paciente. En casos seleccionados se puede optar por una actitud conservadora.

show abstract

Tumores neuroendocrinos no funcionantes de páncreas incidentales de pequeño tamaño: Resultados de una serie con manejo no quirúrgico

Cited by 6 publications

References 32 publications

Insights of Outcome after Resection of Small Nonfunctioning Neuroendocrine Pancreatic Tumors

Insights of Outcome after Resection of Small Nonfunctioning Neuroendocrine Pancreatic Tumors

Development of a non-functional pancreatic neuroendocrine tumor and a duodenal ulceration after cholecystoduodenostomy in a cat

Tumores neuroendocrinos pancreáticos. Nuestra experiencia

Contact Info

Product

Resources

About