Tumoren nach einmaliger Röntgenbestrahlung weißer Ratten in verschiedenem Lebensalter

Reincke, U.; Stutz, E.; Wegner, G

doi:10.1007/bf02395342

Cited by 17 publications

(2 citation statements)

References 21 publications

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“…6 MeV protons from slow neutron captures in the rat tissues (table 3) . The only relevant tumour observed amongst 512 rats given 260 rad of 180 kV X-rays was a single squamous cell carcinoma with no such tumours occurring in 112 non-irradiated controls (Reincke, Stutz and Wegner 1964) . The average LET of the 0 .…”

Section: 2 2 Squamous Cell Carcinoma Of the Lungmentioning

confidence: 99%

The Carcinogenic Effect of Localized Fission Fragment Irradiation of Rat Lung

Batchelor

Buckley

Gore

et al. 1980

International Journal of Radiation Biology and Related Studies

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In a preliminary investigation of 'hot particle' carcinogenesis uranium oxide particles were introduced into the lungs of rats either by intubation of a liquid suspension of the particles or by inhalation of an aerosol. Subsequently the animals were briefly exposed to slow neutrons in a nuclear reactor, resulting in localized irradiation of the lung by fission fragments emitted from 235U atoms in the oxide particles. The uranium used in the intubation experiments was either enriched or depleted in 235U. Squamous cell carcinomas developed at the site of deposition of the enriched uranium oxide in many cases but no lung tumours occurred in the rats with the depleted uranium oxide, in which the lung tissue was exposed to very few fission fragments. Only enriched uranium oxide was used in the inhalation experiments. Pulmonary squamous cell carcinomas occurred after the fission fragment irradiation but were fewer than in the intubation experiments. Adenocarcinomas of the lung were seen in rats exposed to uranium oxide without subsequent irradiation by neutrons in the reactor and in rats irradiated with neutrons but not previously exposed to uranium oxide. It is concluded that (i) fission fragments were possibly implicated in the genesis of the squamous cell carcinomas, which only developed in those animals exposed to enriched uranium oxide and neutrons and (ii) the adenocarcinomas in the rats inhaling enriched uranium oxide only were likely to have been caused by protracted irradiation of the lung with alpha-rays emitted from the enriched uranium.

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Section: 2 2 Squamous Cell Carcinoma Of the Lungmentioning

confidence: 99%

The Carcinogenic Effect of Localized Fission Fragment Irradiation of Rat Lung

Batchelor

Buckley

Gore

et al. 1980

International Journal of Radiation Biology and Related Studies

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“…In most instances fibrosarcomas have been relatively rare after whole-body irradiation of rats and mice (Upton, Kimball, Furth, Chrestenberry and Benedict 1960, Reincke, Stutz and Wegner 1964, Reincke, Stutz and Hunstein 1965 but rats which survived an LD70 exposure of 660 R had an incidence of 11 per cent (Koletsky and Gustafson 1955) . In the present series of whole-body irradiated rabbits the medium dose groups, which were irradiated at well below the LD50 level, had an incidence of 50 and 63 per cent and even the low dose of neutrons produced 27 per cent (table 4) .…”

Section: 1 Fibrosarcomasmentioning

confidence: 99%

Tumour Incidence and Longevity in Neutron and Gamma-irradiated Rabbits, with an Assessment of R.b.e.

Hulse

1980

International Journal of Radiation Biology and Related Studies

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Rabbits were kept for the whole of their natural life-span (6-9 years) after exposures of 440-1410 rad of gamma-rays or 180-550 rad of fission neutrons . Irradiated rabbits did not live as long as unirradiated controls but the difference was statistically significant only after the higher doses of neutrons . Earlier deaths were explained by increased incidences of a wide variety of tumours . The increases were statistically significant for basal-cell tumours of the skin, fibrosarcomas, osteosarcomas and Sertoli-cell tumours of the testis . Other phenomena associated with natural ageing were unchanged or decreased in irradiated rabbits .The r .b .e . of the neutrons was assessed as 3-3. 5 for tumour induction and 3 . 5-4 .0 for longevity . Comparisons with previous data on acute and subacute effects suggest that the r .b .e . increased linearly with the logarithm of time for 5-2000 days after irradiation .

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Inhibition of radiogenic mammary carcinoma in rats by estriol or tamoxifen

Lemon

Kumar

Peterson

et al. 1990

Cancer

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Mammary carcinomas have been induced by 3.5 Gy whole-body gamma radiation administered at age 40 to 50 days to virgin female Sprague-Dawley rats. In 142 irradiated controls carcinoma incidence averaged 7.8% in survivors observed less than 300 days and 38.3% of those surviving longer (P less than 0.001 by t test). Mammary cancer promotion was inhibited by two methods: estriol (E3) 638 micrograms/month (2.2 microns/mo) subcutaneously for natural life span begun 2 weeks after exposure reduced cancer incidence from 76% in controls to 48% after 331 to 449 mean days observation until neoplasia was palpable (P less than 0.02 by chi-square analysis). Uterine weights were similar in control and treated groups, and were 15% to 18% greater than uteri of nonirradiated controls from other simultaneous experiments. Six monthly 638-micrograms doses of 17 alpha ethinyl estriol (EE3) reduced tumors from 88% in controls to 64% (P less than 0.05 by chi-square analysis) and delayed cancer onset (P less than 0.01-0.04 by life table analysis). Ethinyl estradiol (EE2) after 6 months' treatment similarly delayed mammary tumor development reducing incidence to 75% (NS), with a six-fold increase in nonmammary epithelial malignant tumors. Estriol administration begun between 3 days before to 5 days after radiation did not alter mammary cancer incidence in six experiments. Monthly implantation of 2.5 mg tamoxifen (4.44 microns/mo) started 2 weeks after radiation reduced mammary cancer incidence from 83% to 14% after 307 to 314 days' observation (P less than 0.001 by chi-square analysis). Treated rats had atrophic ovaries and uteri consistent with blockade of endogenous estradiol activity. Short-term parenteral E3 or EE3 therapy using 10 to 30 micrograms/kg/day (35-100 microns/kg/day) rapidly differentiated virgin rat mammary glands without impairment of subsequent estrus cycles and offers an alternative to castration or life-long antiestrogen therapy for reduction of risk of radiogenic mammary carcinoma.

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Tumoren nach einmaliger Röntgenbestrahlung weißer Ratten in verschiedenem Lebensalter

Cited by 17 publications

References 21 publications

The Carcinogenic Effect of Localized Fission Fragment Irradiation of Rat Lung

The Carcinogenic Effect of Localized Fission Fragment Irradiation of Rat Lung

Tumour Incidence and Longevity in Neutron and Gamma-irradiated Rabbits, with an Assessment of R.b.e.

Inhibition of radiogenic mammary carcinoma in rats by estriol or tamoxifen

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