Tumoral melanosis associated with nivolumab therapy for metastatic melanoma

Is tumoral melanosis still a challenge? A case of tumoral melanosis without metastasis

“…Lesions are usually oligo-symptomatic and persistent. 1 The cases present different grades of severity, from localized comedonal lesions to generalized comedones, nodules, and cysts like our case. The diagnosis can be challenging as it can be misdiagnosed as acne vulgaris, trichoepithelioma, familial dyskeratotic comedones, or warty dyskeratoma.…”

“…Histopathologically, CDD is characterized by acantholytic and dyskeratotic cells located in the follicular adnexal epithelium of variable enlarged hair follicles. 1,2 The keratin profile in CDD has also been reported presenting similari-…”

“…Clinically, it manifests as hyperpigmented flat or nodular lesions in sites of regressed melanocytic proliferations, including primary and metastatic melanoma. 1 Herein, we report a distinctive case of diffuse TM without any evidence of metastatic disease.…”

“…This entity has been related to completely regressed melanoma, and exceptionally it has also been reported in regressed epithelial lesions. 1 Recently, it has been described in the context of advanced melanoma treated with immunotherapy, and its identification in a patient with a history of melanoma can be a harbinger of metastatic disease. 2,3 The prognosis of TM is still unclear due to the limited number of reported cases with long-term follow-up.…”