Tumoral calcinosis with unusual dental radiographic findings

Witcher, S. L.; Drinkard, Donald W.; Shapiro, Robert; Schow, Carl E.

doi:10.1016/0030-4220(89)90123-0

Cited by 13 publications

(11 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is therefore not surprising that this condition is observed with greater frequency in patients with systemic disorders in which the "calcium-phosphate" product is elevated, particularly in hyperphosphatemic disorders such as vitamin D intoxication, chronic renal failure, and hyperphosphatemic tumoral calcinosis [4,9,14,25]. The latter disorder appears to be an autosomal dominant disease with variable penetrance, characterized by inappropriately avid renal phosphate retention, inappropriately high serum levels of the hormonal form of vitamin D (1,25-dihydroxyvitamin D), and a unique hypoplastic dental lesion [27,46].…”

Section: Discussionmentioning

confidence: 99%

Tumoral calcinosis-like lesion of the proximal linea aspera

et al. 1990

View full text Add to dashboard Cite

Abstract. Tumoral calcinosis is presently a poorly defined disease. In its classic form, it consists of multiple large foci of benign mineralization in the soft tissuc adjacent to bone near large joints. Patients are generally of African descent and are adolescents or young adults at presentation. Both metabolic and traumatic etiologies have been proposed. We report six adult Caucasian patients with lesions that pathologically resembled tumoral calcinosis. All lesions were small (less than 3 x 3 cm) and were located along the proximal 1inca aspera of the femur. All patients presented with pain. Because of the atypical patient population and the unusual size and location of the lesions, we refer to this process as a "tumoral calcinosis-like lesion." A typical radiographic appearance and location, together with appropriate clinical history, can strongly suggest this diagnosis.

show abstract

Section: Discussionmentioning

confidence: 99%

Tumoral calcinosis-like lesion of the proximal linea aspera

et al. 1990

View full text Add to dashboard Cite

show abstract

“…In hyperphosphatemic familial tumoral calcinosis (HFTC), the dental root malformations, which include pulp stones and pulp obliteration and a local thickening of the permanent tooth roots, are somewhat specific for this disorder and can serve as a phenotypic marker; 14 these malformations seem to fit somewhere between the classic descriptions for DD-I and DD-II. 15 The hallmark of hyperphosphatemic diseases is tumoral calcinosis. Ectopic calcifications are often observed in the thyroid cartilage and the large muscles of the lower extremities but can occur at many sites, such as the placenta, iliac vessels, and bone (resembling osteoarthritis).…”

mentioning

confidence: 99%

Root anomalies and dentin dysplasia in autosomal recessive hyperphosphatemic familial tumoral calcinosis (HFTC)

Vieira

Lee

Vairo

et al. 2015

Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology

View full text Add to dashboard Cite

Hyperphosphatemic familial tumoral calcinosis (HFTC, OMIM #211900) is an autosomal recessive metabolic disorder characterized by hyperphosphatemia, tooth root defects, and the progressive deposition of calcium phosphate crystals in periarticular spaces, soft tissues, and sometimes bone.1 In this HFTC case report, we document the dental phenotype associated with a homozygous missense mutation (g.29077 C>T; c.484 C>T; p.Arg162*) in GALNT3 (OMIM 6017563), a gene encoding UDP-GalNAc transferase 3 that catalyzes the first step of O-linked oligosaccharide biosynthesis in the Golgi. The medical and dental pathology is believed to be caused primarily by high serum phosphate levels (hyperphosphatemia), which, in turn, is caused by failure of GALNT3 to glycosylate the phosphate regulator protein FGF23, impairing its ability inhibit reabsorption of filtered phosphate in the kidneys.

show abstract

“…(2) and by HOGGINS & MARSLAND (3). Most other reports of tumoral calcinosis (4)(5)(6)(7)(8) do not give descriptions of dental radiographs and histopathology of teeth so the number of TC patients having dental lesions cannot be determined. The data from the kindred previously described by LYLES et al (1) suggest that tumoral calcinosis may be variably expressed in affected individuals, and that an elevated serum 1,25-dihydroxyvitamin D level is a generalized phenome-non occuring in all affected subjects even when no other clinical markers for the disorders are present.…”

mentioning

confidence: 99%

Dental lesions in tumoral calcinosis

Burkes

Lyles

Dolan

et al. 1991

J Oral Pathology Medicine

View full text Add to dashboard Cite

Tumoral calcinosis (TC) is a rare inherited autosomal dominant metabolic disease manifested by elevated serum phosphorus and 1,25 dihydroxyvitamin D levels and periarticular cystic and solid tumorous calcifications. The dental findings in a large family have been critical in determining the genetic transmission of the condition. Radiographically the teeth have short bulbous roots, pulp stones and partial obliteration of the pulp cavity. Histologically, coronal dentin and a variable amount of radicular dentin appears to be deposited regularly. At nonspecific points the developing radicular dentin appears to encounter a mass of calcified material and proceed to grow around it. This mass has a unique histologic pattern with ovoid spaces surrounded by amorphous calcification. At levels of further root development the radicular dentin has an irregular bending tubule arrangement. The dental lesion of TC appears to be different from that of radicular dentin dysplasia in histologic structure and in the method of initiation of the dentin defect. These data suggest that the specific dental lesion is a new phenotypic marker for TC.

show abstract

Tumoral calcinosis with unusual dental radiographic findings

Cited by 13 publications

References 14 publications

Tumoral calcinosis-like lesion of the proximal linea aspera

Tumoral calcinosis-like lesion of the proximal linea aspera

Root anomalies and dentin dysplasia in autosomal recessive hyperphosphatemic familial tumoral calcinosis (HFTC)

Dental lesions in tumoral calcinosis

Contact Info

Product

Resources

About