1989
DOI: 10.1016/0030-4220(89)90123-0
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Tumoral calcinosis with unusual dental radiographic findings

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Cited by 13 publications
(11 citation statements)
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“…It is therefore not surprising that this condition is observed with greater frequency in patients with systemic disorders in which the "calcium-phosphate" product is elevated, particularly in hyperphosphatemic disorders such as vitamin D intoxication, chronic renal failure, and hyperphosphatemic tumoral calcinosis [4,9,14,25]. The latter disorder appears to be an autosomal dominant disease with variable penetrance, characterized by inappropriately avid renal phosphate retention, inappropriately high serum levels of the hormonal form of vitamin D (1,25-dihydroxyvitamin D), and a unique hypoplastic dental lesion [27,46].…”
Section: Discussionmentioning
confidence: 99%
“…It is therefore not surprising that this condition is observed with greater frequency in patients with systemic disorders in which the "calcium-phosphate" product is elevated, particularly in hyperphosphatemic disorders such as vitamin D intoxication, chronic renal failure, and hyperphosphatemic tumoral calcinosis [4,9,14,25]. The latter disorder appears to be an autosomal dominant disease with variable penetrance, characterized by inappropriately avid renal phosphate retention, inappropriately high serum levels of the hormonal form of vitamin D (1,25-dihydroxyvitamin D), and a unique hypoplastic dental lesion [27,46].…”
Section: Discussionmentioning
confidence: 99%
“…In hyperphosphatemic familial tumoral calcinosis (HFTC), the dental root malformations, which include pulp stones and pulp obliteration and a local thickening of the permanent tooth roots, are somewhat specific for this disorder and can serve as a phenotypic marker; 14 these malformations seem to fit somewhere between the classic descriptions for DD-I and DD-II. 15 The hallmark of hyperphosphatemic diseases is tumoral calcinosis. Ectopic calcifications are often observed in the thyroid cartilage and the large muscles of the lower extremities but can occur at many sites, such as the placenta, iliac vessels, and bone (resembling osteoarthritis).…”
mentioning
confidence: 99%
“…(2) and by HOGGINS & MARSLAND (3). Most other reports of tumoral calcinosis (4)(5)(6)(7)(8) do not give descriptions of dental radiographs and histopathology of teeth so the number of TC patients having dental lesions cannot be determined. The data from the kindred previously described by LYLES et al (1) suggest that tumoral calcinosis may be variably expressed in affected individuals, and that an elevated serum 1,25-dihydroxyvitamin D level is a generalized phenome-non occuring in all affected subjects even when no other clinical markers for the disorders are present.…”
mentioning
confidence: 99%