Tumoral Calcinosis in the Nose in a Patient With Scleroderma

Abstract

Tumoral calcinosis is a rare calcifying disorder with deposition of calcium phosphate and calcium hydroxyapatite within the soft tissue at periarticular sites. There have been series of sporadic cases of tumoral calcinosis in the trunk and the extremities due to renal failure. However, we describe a 35-year-old woman without renal problems or trauma history who had tumoral calcinosis in the nose. This is the first report on facial occurrence.

Calcium orthophosphates (CaPO4): occurrence and properties

“…According to the data available (Poloni and Ward 2014 ), the unwanted depositions could consist of many substances and all of them always lead to various diseases. Regarding the unwanted depositions of CaPO 4 , they are found in soft tissue calcification (in damaged joints, blood vessels, dysfunctional areas in the brain, diseased organs, scleroderma, prostate stones) (Reid and Andersen 1993 ; Scotchford and Ali 1995 ; P’ng et al 2008 ; Brancaccio and Cozzolino 2005 ; Goff and Reichard 2006 ; Bittmann et al 2003 ; Molloy and McCarthy 2006 ; Giachelli 2004 ; Kazama et al 2007 ), kidney (Giannossi and Summa 2012 ; Mukherjee 2014 ) and urinary (Zhu et al 2014 ; Huo et al 2015 ; Selvaraju et al 2015 ) stones, dental pulp stones and dental calculus (Kakei et al 2009 ; Kodaka et al 1988 , 1998 ; Çiftçioglu et al 1998 ; Hayashizaki et al 2008 ), salivary stones (Zelentsov et al 2001 ; Luers et al 2014 ), gall stones (Qiao et al 2013 ; Hussain and Al-Jashamy 2013 ), pineal gland calcifications (Güney et al 2013 ), atherosclerotic arteries and veins (Ortlepp et al 2004 ; Tomazic 2001 ; Marra et al 2006 ; Kurabayashi 2013 ), coronary calcification (Fitzpatrick et al 2003 ; Matsui et al 2015 ), damaged cardiac valves (Suvorova and Buffat 2005 ), calcification on artificial heart valves (Giachelli 2001 ; Pettenazzo et al 2001 ; Schoen and Levy 2005 ; Delogne et al 2007 ), carpal tunnel (Sensui et al 2003 ; Namba et al 2008 ) and tumoral (Namba et al 2008 ; Carlson et al 2007 ; Sprecher 2010 ; Slavin et al 2012 ; Kim et al 2013 ; Burns et al 2013 ) calcifications, cataracts (Kim and Choi 2007 ; Koinzer et al 2009 ), malacoplakia (Ho 1989 ), calcified menisci (Katsamenis et al 2...…”

“…One author has mentioned on “apatite diseases” which are characterized by the appearance of needle-like crystals comparable to those of bone apatite in the fibrous connective tissue (Mohr 2003 ). All these cases are examples of a calcinosis (Sprecher 2010 ; Slavin et al 2012 ; Kim et al 2013 ; Burns et al 2013 ), which might be described as a formation of undesired CaPO 4 deposits in any soft tissue. In dentistry, a calculus or a tartar refers to a hardened plaque on the teeth, formed by the presence of saliva, debris and minerals (White 1997 ).…”

Calcium orthophosphates (CaPO 4 ): Occurrence and properties

“…One author has mentioned on ''apatite diseases'' which are characterized by the appearance of needle-like crystals comparable to those of bone apatite in the fibrous connective tissue (Mohr 2003). All these cases are examples of a calcinosis (Sprecher 2010;Slavin et al 2012;Kim et al 2013;Burns et al 2013), which might be described as a formation of undesired CaPO 4 deposits in any soft tissue. In dentistry, a calculus or a tartar refers to a hardened plaque on the teeth, formed by the presence of saliva, debris and minerals (White 1997).…”