Tumoral calcinosis: Evidence for concurrent defects in renal tubular phosphorus transport and in 1α,25-dihydroxycholecalciferol synthesis

Zerwekh, Joseph E.; Sanders, L. A.; Townsend, J C; Pak, Charles Y.C.

doi:10.1007/bf02408515

Cited by 41 publications

(9 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Hyperphosphatemia has been found in some individuals, but serum calcium and parathyroid hormone levels are reported normal [3,21,22,24,26,32,34,35,38,45]. An apparent inherited disorder of phosphate and vitamin D metabolism has also been described [8,19,28,34,37,38,48]. Trauma has been implicated as a cause in selected patients [5,10,15,30,36,39,42,44].…”

Section: Discussionmentioning

confidence: 99%

Tumoral calcinosis-like lesion of the proximal linea aspera

et al. 1990

View full text Add to dashboard Cite

Abstract. Tumoral calcinosis is presently a poorly defined disease. In its classic form, it consists of multiple large foci of benign mineralization in the soft tissuc adjacent to bone near large joints. Patients are generally of African descent and are adolescents or young adults at presentation. Both metabolic and traumatic etiologies have been proposed. We report six adult Caucasian patients with lesions that pathologically resembled tumoral calcinosis. All lesions were small (less than 3 x 3 cm) and were located along the proximal 1inca aspera of the femur. All patients presented with pain. Because of the atypical patient population and the unusual size and location of the lesions, we refer to this process as a "tumoral calcinosis-like lesion." A typical radiographic appearance and location, together with appropriate clinical history, can strongly suggest this diagnosis.

show abstract

Section: Discussionmentioning

confidence: 99%

Tumoral calcinosis-like lesion of the proximal linea aspera

et al. 1990

View full text Add to dashboard Cite

show abstract

“…The intra-and interassay variations were 8.5 and 15.0% respectively. Serum 25(OH) D 3 was assayed by means of a rat serum binding protein system (21,22).…”

Section: Biochemical Measurementmentioning

confidence: 99%

Skeletal responsiveness to parathyroid hormone in pseudohypoparathyroidism

Kanatani

Sugimoto²,

Kaji³

et al. 2001

European Journal of Endocrinology

View full text Add to dashboard Cite

Background: Although there have been some case reports suggesting that bone in patients with pseudohypoparathyroidism (PHP) might respond to parathyroid hormone (PTH), no information is available as to whether serum PTH concentration is related to bone metabolic markers or to bone mineral density (BMD) in PHP. Objective: To address these relationships, by comparing intact serum PTH, bone metabolic markers and BMD in patients with PHP with those in patients with idiopathic hypoparathyroidism (IHP) and postoperative hypoparathyroidism (OHP). Methods: Intact serum PTH, bone metabolic markers (osteocalcin, tartrate-resistant acid phosphatase, pyridinoline, deoxypyridinoline) and BMD by dual-energy X-ray absorptiometry or single-photon absorptiometry were measured in patients with PHP Ia n 2 and PHP Ib n 8X The results were compared with those in patients with IHP n 5 and OHP n 14X Results: All bone metabolic markers measured were present in significantly greater amounts in patients with PHP Ib than in those with IHP+OHP. The Z score (standard deviation of average BMD at each age) of the BMD of femoral neck was significantly lower in patients with PHP Ib than in those with IHP+OHP. The Z scores of BMD of lumbar spine and radius were also lower in patients with PHP Ib than in those with IHP+OHP, but the difference was not significant. Moreover, the intact serum PTH concentrations were significantly and positively related to bone metabolic marker levels in all patients, and the intact serum PTH concentrations were significantly and negatively related to BMD of lumbar spine in PHP patients. Conclusions: These results suggest that PTH stimulates bone turnover in PHP Ib patients, resulting in a relatively lower BMD in PHP Ib patients than in IHP+OHP patients. The present study indicates that bones of most cases of PHP could respond to PTH.

show abstract

“…Irradiation was not found to be effective. Dietary restrictions of calcium and phosphorus [18,26] or a ketogenic diet [6], if at all helpful, are unacceptable for children in their growth period. Colchicine is only feasible for a limited period of time.…”

Section: Discussionmentioning

confidence: 99%

Tumoral calcinosis revisited ? common and uncommon features

Metzker

Eisenstein

Oren³

et al. 1988

Eur J Pediatr

View full text Add to dashboard Cite

Familial cutaneous and subcutaneous tumoral calcifications are a recognized entity of unknown pathogenesis. The course of calcinosis and various treatments are discussed and the literature concerning the aetiology is reviewed. Our ten cases provided some experience in dealing with tumoral calcinosis and demonstrated, in addition, some clinical phenomena unrecognized previously, such as involvement of the mucous membranes and an erythematous rash preceding the development of calcified nodules.

show abstract

Tumoral calcinosis: Evidence for concurrent defects in renal tubular phosphorus transport and in 1α,25-dihydroxycholecalciferol synthesis

Cited by 41 publications

References 25 publications

Tumoral calcinosis-like lesion of the proximal linea aspera

Tumoral calcinosis-like lesion of the proximal linea aspera

Skeletal responsiveness to parathyroid hormone in pseudohypoparathyroidism

Tumoral calcinosis revisited ? common and uncommon features

Contact Info

Product

Resources

About