Tumoraciones mesenquimales de músculo liso de potencial maligno incierto (STUMP): revisión de un caso clínico

Muñoz, M. Guzmán; García-Pineda, V.; Arnanz, F.; Martínez-Gómez, Eduardo; Díez‑Corral, Cristina; Zapico, A.

doi:10.1016/j.gine.2011.06.002

Cited by 6 publications

(9 citation statements)

References 8 publications

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“…In our case series, as in the published literature [ 1 , 6 , 8 ], suspicions of STUMP had not been established prior to the interventions, since the signs and symptoms were similar to those of leiomyomas (abnormal uterine bleeding, pelvic pain, and pelvic compression). Only in one case was there suspicion of malignancy due to rapid growth and the appearance of degeneration in radiology (case no.…”

Section: Discussionmentioning

confidence: 84%

“…The diagnosis of benignity (leiomyoma) is characterized by an absence of atypia and tumour necrosis and ≤4 MF/10 HPF. Some variants of leiomyoma include more than 5 and less than 19 MF/HPF (mitotically active leiomyoma), or cytological atypia without tumour necrosis and <10 MF/10 HPF (atypical leiomyoma) [ 8 ], although this term is not universally accepted by pathologists. At present, “bizarre leiomyomas” or “leiomyomas with bizarre nuclei”, are classified as benign myomas [ 6 ].…”

Section: Discussionmentioning

confidence: 99%

“…Other factors have been related to tumour recurrence: after primary surgery by morcellation, it could be possible to disseminate the tumour if an unprotected morcellation is used [ 5 ]. Other less important prognostic factors include the infiltration of surgical borders, postmenopausal patients, and a tumour size greater than 3 cm [ 8 ].…”

Section: Discussionmentioning

confidence: 99%

“…Nevertheless, some patients can be asymptomatic, leading to a delayed diagnosis that might lead to a worse prognosis [5,6]. It is thought that STUMP may be the transition from leiomyoma to leiomyosarcoma or a sometimes underestimated low-grade leiomyosarcoma [7,8]. Most reports of uterine STUMP have found similar age of diagnosis to that of fibroids or sarcomas, and the median age of this is between 40 to 50 years [5].…”

Section: Introductionmentioning

confidence: 99%

“…Most reports of uterine STUMP have found similar age of diagnosis to that of fibroids or sarcomas, and the median age of this is between 40 to 50 years [ 5 ]. Compared to sarcomas, they have a better prognosis, but their biological potential is uncertain, as recurrence, malignization, and metastases are possible until many years later (11% mean recurrence rate diagnosed after a mean time of 51 months from initial diagnosis) [ 8 ]. It has been suggested that recurrence is more likely at younger ages [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

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A Review and Follow-Up of Uterine Smooth Muscle Tumours of Uncertain Malignant Potential (STUMP): A Case Series and Literature Review

Lapresa-Alcalde,

Ruiz-Navarro,

Sancho de Salas

et al. 2023

Diseases

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Objectives: to analyse the clinical–pathological characteristics, treatment, and evolution of uterine smooth muscle tumours with uncertain malignant potential (STUMP) diagnosed in the Salamanca University Hospital with the implementation of the 2014 WHO criteria. Materials and methods: a retrospective descriptive study of patients diagnosed with STUMP from January 2015 to March 2023 at the Salamanca University Hospital. Demographic data, preoperative clinical data, treatment, complications, therapeutic results, anatomopathological findings and recurrence time were obtained. Results: a total of four patients were identified and included in the study. The mean age at diagnosis was 48 years (range 36–67). The surgical indications were abnormal uterine bleeding, compressive symptoms, and the growth of a pelvic mass suspected to be a degenerated myoma from the residual cervix after a subtotal hysterectomy 6 years earlier. In all cases, a laparotomic procedure was performed. A total hysterectomy, sub-total hysterectomy, and the excision of the cervix with STUMP localization were accomplished in two, one, and one patient, respectively. The mean diameter of the tumour pieces was 13 cm (range 8–17 cm), with a mean volume of 816 cc (range 234–1467 cc). The mean follow-up was 47 months, with no recurrence to date. Conclusions: STUMPs are a heterogeneous group of tumours with a difficult-to-predict clinical evolution. In most cases, their diagnosis is histological after performing surgery for suspected leiomyoma. Due to their low incidence, there are no specific guidelines for their treatment and control. However, considering their potential risk of recurrence and metastasis, it is advisable to maintain six-monthly controls for 5 years and then annual controls for 5 years more.

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Section: Discussionmentioning

confidence: 84%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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A Review and Follow-Up of Uterine Smooth Muscle Tumours of Uncertain Malignant Potential (STUMP): A Case Series and Literature Review

Lapresa-Alcalde,

Ruiz-Navarro,

Sancho de Salas

et al. 2023

Diseases

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Tumor de estirpe mesenquimal uterino: Presentación de caso clínico y revisión bibliográfica

Gavilanes Sáenz,

López Haro

2024

MedicienciasUTA

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Introducción: Los tumores mesenquimales uterinos son relativamente frecuentes, se clasifican ampliamente en leiomiomas, leiomiosarcomas y tumores de músculo liso de potencial maligno incierto (STUMP). Su clínica es inespecífica y en ciertos casos debido a la dificultad en su diagnóstico se necesitan estudios especiales para ser clasificados como totalmente benignos o malignos. Objetivo: Describir el caso clínico de una paciente con tumor mesenquimal uterino realizando una revision adecuada y actualizada de la bibliografía. Materiales y métodos: Estudio descriptivo retrospectivo, mediante la presentación de un caso clínico. Previamente se obtuvo el consentimiento informado de la paciente, se realizó una revisión sistemática de información científica en los buscadores bibliográficos PubMed, Scopus, Nature Portafolio, Springer Link y Scielo. Resultados: Paciente de 50 años que consultó por distención abdominal y dolor abdominal difuso de aproximadamente 3 meses de evolución. Ecográficamente se visualizó una masa de contenido heterogéneo que impresiona originarse en ovarios con volumen de 4575 cc, la misma que se confirmó por tomografía axial computarizada, posteriormente se decide laparotomía exploratoria encontrando masa abdominopélvica dependiente de cuerno uterino izquierdo que impresiona mioma subseroso gigante con adherencias y abundante neovascularización a mesenterio por lo que se realiza histerectomía más anexectomía, se envía para estudio histopatológico que reveló neoplasia de estirpe mesenquimal sin especificar diagnóstico de benignidad o malignidad por lo que se solicita estudio inmunohistoquímico para clasificarlo. Conclusiones: A pesar de que la intervención quirúrgica constituye una medida inicial en el tratamiento ante la sospecha de tumor mesenquimal, resulta imperativo validar el diagnóstico mediante análisis histopatológico, inmunohistoquímico y, en algunos casos, mediante evaluación de la genética molecular. Este enfoque se realiza con el propósito de discernir entre una lesión maligna o benigna, permitiendo así la implementación de un protocolo de manejo y seguimiento apropiado

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Tumor de músculo liso uterino de potencial maligno incierto (STUMP): reporte de caso y revisión de la literatura

Serrano Ortiz,

Hernández Gómez,

Santana

et al. 2023

Rev. colomb. cancerol.

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Las neoplasias del músculo liso miometrial son los tumores ginecológicos más comunes, con una prevalencia de 70-80% a los 50 años. Entre las mujeres sometidas a histerectomía o miomectomía por un presunto diagnóstico de leiomioma, el 0,01% recibe el diagnóstico de STUMP. Clínicamente, la edad promedio de presentación es entre los 41-48 años. Se han descrito tumores desde 3 cm hasta 30 cm. Los signos y síntomas son similares a los leiomiomas, como sangrado uterino anormal, anemia, dismenorrea, dolor pélvico, masa pélvica, infertilidad u otros tipos de dolor secundario a la compresión de órganos adyacentes. Debido a la poca literatura disponible, no se tiene un consenso de manejo definido y las opciones de manejo y seguimiento se limitan a estudios observacionales. El tratamiento estándar es la histerectomía total con o sin salpingooforectomía bilateral si ya se ha completado la fertilidad, no hay rol para la terapia hormonal adyuvante o la quimioterapia. La supervivencia global a 5 años es de 92-100%. Se presenta el caso de una mujer de 31 años con un STUMP.

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Tumoraciones mesenquimales de músculo liso de potencial maligno incierto (STUMP): revisión de un caso clínico

Cited by 6 publications

References 8 publications

A Review and Follow-Up of Uterine Smooth Muscle Tumours of Uncertain Malignant Potential (STUMP): A Case Series and Literature Review

A Review and Follow-Up of Uterine Smooth Muscle Tumours of Uncertain Malignant Potential (STUMP): A Case Series and Literature Review

Tumor de estirpe mesenquimal uterino: Presentación de caso clínico y revisión bibliográfica

Tumor de músculo liso uterino de potencial maligno incierto (STUMP): reporte de caso y revisión de la literatura

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