Tumor vascularity in ovarian cancer

Abstract

Tumor-infiltrating lymphocytes (TILs) are crucial for effective antitumor responses. However, hypoxia can skew T-cell differentiation and function, thereby perturbing TILs. We have demonstrated that TILs and their immune function are associated with tumor vascularization. These features are prognostic for improved disease-specific survival in ovarian cancer. Thus, new immunotherapies should consider how hypoxia impacts antitumor immunity.

Patterns of immune-cell infiltration in murine models of melanoma: roles of antigen and tissue site in creating inflamed tumors

“…Immune infiltration has been linked to intratumoral vascular abnormalities in human cancers [23]. We wished to determine whether the distributions of immune cells in Immunotypes B and C were related to differences in vascular density.…”

Prediction of immunocyte infiltration and prognosis in postoperative hepatitis B virus-related hepatocellular carcinoma patients using magnetic resonance imaging

“…The RE in the tumoral region is related to the arterial blood supply, oxygen supply, and tumor angiogenesis, which are closely associated with the activity of leukocyte and B lymphocyte infiltration [ 24 , 25 ]. A study has shown that immunocyte infiltration in tumors and their functions are related to tumor vascularization, which is closely associated with the prognosis of patients undergoing immunotherapy [ 26 ]. In this study, a negative correlation was found between the T1 pos and Treg cell infiltration in the tumor.…”