Tumor vascular permeability and the EPR effect in macromolecular therapeutics: a review

Maeda, Hiroshi; Wu, Jun; Sawa, Tomohiro; Matsumura, Yasuhiro; Hori, Kentaro

doi:10.1016/s0168-3659(99)00248-5

Cited by 5,832 publications

(3,986 citation statements)

References 39 publications

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“…This effect relies on the fact that under some conditions, for example, inflammation which is typical for tumors and other pathological sites, the endothelial lining of the blood vessel wall become more permeable than under physiological conditions which allows particles ranging from 200 to 800 nm in size to accumulate inside the interstitial space [93]. These nanoparticles loaded with pharmaceutical agent have the ability to deliver their payload into the increased permeability area and release the drug very close to their target [93,94].…”

Section: Nano Pdt Passive Nanoparticlesmentioning

confidence: 99%

“…It is necessary for them to stay in blood system for extended time to provide a sufficient level of accumulation in the target area [93]. Thus, long-circulating pharmaceutical nanocarriers such as liposomes, micelles or polymeric nanoparticles are capable to accumulate in pathological area through the EPR effect and are widely use for drug delivery into tumor [93,94,95]. Nevertheless, this has to be carefully monitored as in the case of PDT this can also result in longer photosensitivity.…”

Section: Nano Pdt Passive Nanoparticlesmentioning

confidence: 99%

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Nanodrug applications in photodynamic therapy

Paszko

Ehrhardt

Senge

et al. 2011

Photodiagnosis and Photodynamic Therapy

319

210

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SummaryPhotodynamic therapy (PDT) has developed over last century and is now becoming a more widely used medical tool having gained regulatory approval for the treatment of various diseases such as cancer and macular degeneration. It is a two-step technique in which delivery of a photosensitizing drug is followed by irradiation of light. Activated photosensitizers transfer energy to molecular oxygen which results in generation of reactive oxygen species which in turn cause cells apoptosis or necrosis. Although this modality has significantly improved quality of life and survival time for many cancer patients it still offers significant potential for further improvement. In addition to the development of new PDT drugs, the use of nanosized carriers for photosensitizers is a promising approach which might improve the efficiency of photodynamic activity and which can overcome many side effects associated with classic photodynamic therapy. This review aims at highlighting the different types of nanomedical approaches currently used in PDT and outlines future trends and limitations of nanodelivery of photosensitizers. PDT -photodynamic therapy; PGA -poly(glycolic acid); PGLA -poly(D,L-lactide-coglycolide); PLA -poly(lactic acid); PS -photosensitizer; PEG -polyethylene glycol; ALA  aminolevulinic acid; m-THPC  5,10,15,20-tetra-(m-hydroxyphenyl)chlorine; m-THPP  meso-tetra(p-hydroxyphenyl); PpIX  protoporphyrin; Hp  hematoporphyrin; Pc4  silicon phthalocyanine; Ig  immunoglobulin; Tf  transferrin; TfR  transferrin receptor; VEGF  vascular endothelial growth factor; EPR  enhanced permeability and retention effect; FRET  fluorescence resonance energy transfer; MRI  magnetic resonance imaging; RES  reticuloendothelial system; ROS  reactive oxygen species; NP  nanoparticle; ND -nanodiamonds; SNP  silica nanoparticle; AMD  age-related macular degeneration; CNV  choroidal neovascularization; PTT  photothermal therapy;

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Section: Nano Pdt Passive Nanoparticlesmentioning

confidence: 99%

Section: Nano Pdt Passive Nanoparticlesmentioning

confidence: 99%

Nanodrug applications in photodynamic therapy

Paszko

Ehrhardt

Senge

et al. 2011

Photodiagnosis and Photodynamic Therapy

319

210

View full text Add to dashboard Cite

show abstract

“…The second is AuNPs attaching to targeted ligands (e.g. proteins, antibodies, aptamers, and small molecules), aiming for specific receptors, proteins and cell types [28,41,55,56]. Regarding the shape of AuNPs, some advantages were demonstrated when using star structures, but much work has also been done with spheres [4].…”

Section: Nanoparticles and Raman Techniquesmentioning

confidence: 99%

Application of nanoparticles in cancer detection by Raman scattering based techniques

Ravanshad

Zadeh

Amani

et al. 2017

Nano Reviews & Experiments

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In vitro detection technique Raman spectroscopy (Rs), in one number times another Rs based expert ways of art and so on, are useful instruments for cancer discovery. top gave greater value to Raman spectroscopy sers is a relatively new careful way for in vitro and in vivo discovery that takes away bad points of simple Raman spectroscopy (Rs). Raman spectroscopy (RS) and in particular, multiple RS-based techniques are useful for cancer detection. Surface enhanced Raman spectroscopy (SERS) is a relatively new method for both in vitro and in vivo detection, which eliminates the drawbacks of simple RS. Using nanoparticles has elevated the sensitivity and specificity of SERS. SERS has the potential to increase sensitivity, specificity and spatial resolution in cancer detection, especially in cooperation with other diagnostic imaging tools such as magnetic resonance imaging (MRI) and PET-scan polyethylene terephthalate. Developing a hand held instrument for detecting cancer or other illnesses may also be feasible by using SERS. Frequently, novel nanoparticles are used in SERS. With a focus on nanoparticle utilization, we review the benefits of RS in cancer detection and related biomarkers. With a focus on nanoparticles utilizations, the benefits of RS in cancer detection and related biomarkers were reviewed. In addition, Raman applications to detect some of prevalent were discussed. Also more investigated cancers such as breast and colorectal cancer, multiple nanostructures and their possible special biomarkers, especially as SERS nano-tag have been reviewed. The main purpose of this article is introducing of most popular nanotechnological approaches in cancer detection by using Raman techniques. Moreover, have been caught up on detection and reviewed some of the most prevalent and also more investigated cancers such as breast, colorectal cancer, multiple intriguing nanostructures, especially as SERS nano-tag, special cancer biomarkers and related approaches. The main purpose of this article is to introduce the most popular nanotechnological approaches in cancer detection by using Raman techniques.

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“…Photothermal therapy is comprised of infrared-wavelength-range electromagnetic radiation for treating a number of medical circumstances, including cancer, which is less harmful to non-cancerous cells and tissues and also less energetic [159]. Gene therapy approaches involve gene manipulation on broad biological processes accountable for the spreading of diseases, hence making them a potential approach for the treatment of diverse cancers.…”

Section: Brief Overview Of Photothermal/radiation/gene Therapymentioning

confidence: 99%

Possible role of nanocarriers in drug delivery against cervical cancer

Gupta

2017

Nano Reviews & Experiments

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Introduction: Cervical cancer is the second most common cancer and the largest cancer killer among women in most developing countries including India. Although, various drugs have been developed for cervical cancer, treatment with these drugs often results in a number of undesirable side effects, toxicity and multidrug resistance (MDR). Also, the outcomes for cervical cancer patients remain poor after surgery and chemo radiation. Methods: A literature search (for drugs and delivery systems against cervical cancer) was performed on PubMed and through Google. The present review discuss about various methods including its current conventional treatment with special reference to recent advances in delivery systems encapsulating various anticancer drugs and natural plant products for targeting towards cervical cancer. The role of photothermal therapy, gene therapy and radiation therapy against cervical cancer is also discussed. Results: Systemic/targeted drug delivery systems including liposomes, nanoparticles, hydrogels, dendrimers etc. and localized drug delivery systems like cervical patches, films, rings etc. are safer than the conventional chemotherapy which has further been proved by the several drug delivery systems undergoing clinical trials. Conclusion: Novel approaches for the aggressive treatment of cervical cancer will optimistically result in decreased side effects as well as toxicity, frequency of administration of existing drugs, to overcome MDR and to increase the survival rates.

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Tumor vascular permeability and the EPR effect in macromolecular therapeutics: a review

Cited by 5,832 publications

References 39 publications

Nanodrug applications in photodynamic therapy

Nanodrug applications in photodynamic therapy

Application of nanoparticles in cancer detection by Raman scattering based techniques

Possible role of nanocarriers in drug delivery against cervical cancer

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