Tumor treatment by direct electric current-tumor temperature and pH, electrode material and configuration

Miklavčič, Damijan; Serša, Gregor; Kryžanowski, M.; Novaković, Srdjan; Bobanović, Fedja; Golouh, Rastko; Vodovnik, L.

doi:10.1016/0302-4598(93)80080-e

Cited by 63 publications

(52 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…As we have previously shown, a similar antitumor effect, resulting in tumor growth delay of approximately 2 days, was observed in three different electrode configurations (15). Electrotherapy was performed with the anode inserted centrally in the tumor and the cathode S.C. outside of the tumor (anodic ET) or vice versa (cathodic ET); or both electrodes were placed S.C. outside of the tumor so that the tumor lay between ("field" ET).…”

Section: Resultssupporting

confidence: 83%

“…These changes, however, do not explain the observed antitumor effect in field electrotherapy (15). It was also shown that the antitumor effect is not due to temperature rise, nor to metal deposited from the electrodes used (13,15,22). In the present study, an anatomically based numerical model was constructed to determine electric current and power density distributions in electrotherapy where different electrode configurations were used, in order to have more precise knowledge of the levels of electric values in the tumor.…”

Section: Introduction M I K L a V~c Etalmentioning

confidence: 84%

“…Thus pH seems to mediate the cytotoxic effect in tumors when one or both electrodes are inserted in the tumor. These changes, however, do not explain the observed antitumor effect in field electrotherapy (15). It was also shown that the antitumor effect is not due to temperature rise, nor to metal deposited from the electrodes used (13,15,22).…”

Section: Introduction M I K L a V~c Etalmentioning

confidence: 93%

“…Tumor growth retardation has been demonstrated in different murine tumor models (3,5,10,11,12,14,21,23) as well as in patients (1,17,18,20,28). The antitumor effects in murine tumor models were obtained using various electrode configurations; i.e., electrodes were either inserted in the tumor or were placed subcutaneously outside of the tumor, so that the tumor lay between the two electrodes (15). Different possible underlying mechanisms of the observed phenomena already have been examined in previous studies.…”

Section: Introduction M I K L a V~c Etalmentioning

confidence: 99%

“…However, no change of bioelectric potential was observed due to electrotherapy (16). Changes in local pH and temperature were measured and calculated (4,6,9,15); the role of different materials for electrodes was investigated (15,22); and metal dissolution from the electrodes was determined (13). Extreme local changes of pH were predicted and observed around the electrodes (4,6,9).…”

Section: Introduction M I K L a V~c Etalmentioning

confidence: 99%

See 4 more Smart Citations

Tumor Treatment by Direct Electric Current: Computation of Electric Current and Power Density Distribution

Miklavčič

Šemrov

Valenčic

et al. 1997

Electro- and Magnetobiology

View full text Add to dashboard Cite

Electrotherapy by direct electric current was shown to have an antitumor effect in different animal tumor models and in clinic. Information on the current density distributions in the tumor, surrounding tissues, and its differences in the different electrode configurations used in our previous studies could be useful in future studies of electrotherapy mechanisms. Therefore, a three-dimensional, anatomically based, finite element model of the mouse with a subcutaneous tumor was built. Different types of electrotherapy, i.e., different electrode configurations, were modeled by applying appropriate boundaq conditions in the grid points. The magnitude of current density in anodic/cathodic electrotherapy is 50 times higher in the middle and 10 times higher on the edge of the tumor when compared to the "field" electrotherapy. The results of the computation show that the effects of the electrotherapy on tumor growth, which were similar in terms of tumor growth delay in all three configurations, are not directly related to the magnitude of the electric current or power density in the tumor.Address for correseondence: Damijan Miklavcic,

show abstract

Section: Resultssupporting

confidence: 83%

Section: Introduction M I K L a V~c Etalmentioning

confidence: 84%

Section: Introduction M I K L a V~c Etalmentioning

confidence: 93%

Section: Introduction M I K L a V~c Etalmentioning

confidence: 99%

Section: Introduction M I K L a V~c Etalmentioning

confidence: 99%

See 3 more Smart Citations

Tumor Treatment by Direct Electric Current: Computation of Electric Current and Power Density Distribution

Miklavčič

Šemrov

Valenčic

et al. 1997

Electro- and Magnetobiology

View full text Add to dashboard Cite

show abstract

Electrochemical Processes During High‐Voltage Electric Pulses and their Importance in Food Processing Technology

Saulis

Rodaitė‐Riševičienė

Dainauskaitė

et al. 2015

Advances in Food Biotechnology

View full text Add to dashboard Cite

Platinum Nanoparticles to Enable Electrodynamic Therapy for Effective Cancer Treatment

et al. 2019

View full text Add to dashboard Cite

Electrochemical therapy (EChT), by inserting electrodes directly into tumors to kill cancer cells under direct current (DC), is clinically used in several countries. In EChT, the drastic pH variation nearby the inserted electrodes is the main cause of tumor damage. However, its limited effective area and complex electrode configuration have hindered the clinical application of EChT in treating diverse tumor types. Herein, a conceptually new electric cancer treatment approach is presented through an electro‐driven catalytic reaction with platinum nanoparticles (PtNPs) under a square‐wave alternating current (AC). The electric current triggers a reaction between water molecules and chloride ions on the surface of the PtNPs, generating cytotoxic hydroxyl radicals. Such a mechanism, called electrodynamic therapy (EDT), enables effective killing of cancer cells within the whole electric field, in contrast to EChT, which is limited to areas nearby electrodes. Remarkable tumor destruction efficacy is further demonstrated in this in vivo EDT treatment with PtNPs. Therefore, this study presents a new type of cancer therapy strategy with a tumor‐killing mechanism different from existing methods, using nanoparticles with electrocatalytic functions. This EDT method appears to be minimally invasive, and is able to offer homogeneous killing effects to the entire tumor with a relatively large size.

show abstract

Tumor treatment by direct electric current-tumor temperature and pH, electrode material and configuration

Cited by 63 publications

References 13 publications

Tumor Treatment by Direct Electric Current: Computation of Electric Current and Power Density Distribution

Tumor Treatment by Direct Electric Current: Computation of Electric Current and Power Density Distribution

Electrochemical Processes During High‐Voltage Electric Pulses and their Importance in Food Processing Technology

Platinum Nanoparticles to Enable Electrodynamic Therapy for Effective Cancer Treatment

Contact Info

Product

Resources

About