“… 16 These IFDs do not lead to an absence of protein, but rather result in a shorter protein product. In neuroblastoma, both ATRX MEDs and point mutations have been reported, and these aberrations are strongly associated with ALT development 5 , 6 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 . ATRX aberrations are also present in various other pediatric 25 , 31 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 and adult cancers.…”