Tumor Thrombus

Ravina, Mudalsha; Hess, Søren; Chauhan, M. S.; Jacob, Mattakorottu Joseph; Alavi, Abass

doi:10.1097/rlu.0000000000000451

Cited by 31 publications

(12 citation statements)

References 21 publications

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“…The difference in SUV max was significant. In Ravina’s series (31), out of 21 tumor thrombosis cases incidentally detected by FDG PET/CT, 6 were from RCCs. Ferda et al also reported that FDG PET/CT successfully detected all 7 cases with tumor invasion into the inferior vena cava of 60 patients with RCC (19).…”

Section: Fdg Pet/ct For Restaging Rccmentioning

confidence: 99%

The Place of FDG PET/CT in Renal Cell Carcinoma: Value and Limitations

Liu

2016

Front. Oncol.

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Unlike for most other malignancies, application of FDG PET/CT is limited for renal cell carcinoma (RCC), mainly due to physiological excretion of 18F-fluoro-2-deoxy-2-d-glucose (FDG) from the kidneys, which decreases contrast between renal lesions and normal tissue, and may obscure or mask the lesions of the kidneys. Published clinical observations were discordant regarding the role of FDG PET/CT in diagnosing and staging RCC, and FDG PET/CT is not recommended for this purpose based on current national and international guidelines. However, quantitative FDG PET/CT imaging may facilitate the prediction of the degree of tumor differentiation and allows for prognosis of the disease. FDG PET/CT has potency as an imaging biomarker to provide useful information about patient’s survival. FDG PET/CT can be effectively used for postoperative surveillance and restaging with high sensitivity, specificity, and accuracy, as early diagnosis of recurrent/metastatic disease can drastically affect therapeutic decision and alter outcome of patients. FDG uptake is helpful for differentiating benign or bland emboli from tumor thrombosis in RCC patients. FDG PET/CT also has higher sensitivity and accuracy when compared with bone scan to detect RCC metastasis to the bone. FDG PET/CT can play a strong clinical role in the management of recurrent and metastatic RCC. In monitoring the efficacy of new target therapy such as tyrosine kinase inhibitors (TKIs) treatment for advanced RCC, FDG PET/CT has been increasingly used to assess the therapeutic efficacy, and change in FDG uptake is a strong indicator of biological response to TKI.

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Section: Fdg Pet/ct For Restaging Rccmentioning

confidence: 99%

The Place of FDG PET/CT in Renal Cell Carcinoma: Value and Limitations

Liu

2016

Front. Oncol.

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“…Bland non-catheter-related thrombus often has a lower SUV max compared to tumor thrombus. In general, SUV max greater than 3.35–3.63, contiguous intravascular spread from larger tumor, and location in the IVC have all been associated with tumor rather than bland thrombus [5–7]. …”

Section: Discussionmentioning

confidence: 99%

“…Some authors suggest that an inflammatory process surrounding chronic bland thrombus is responsible for associated FDG avidity [1, 2, 5]. When FDG activity occurs at the tip of the catheter that was used for the injection, physical FDG trapping becomes another possibility [1].…”

Section: Discussionmentioning

confidence: 99%

Cardiac Magnetic Resonance for Evaluating Catheter Related FDG Avidity

Jeong

Gage

Berman

et al. 2016

Case Reports in Radiology

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A 53-year-old female with a history of metastatic left arm melanoma presented for F(18) fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) which showed a moderately FDG avid focus at her port catheter tip near the cavoatrial junction. Although catheter tip related FDG avidity has previously been suggested to be bland thrombus or infection, melanoma can metastasize to unusual locations including the superior vena cava. In addition, the patient had an elevated risk of anticoagulation due to a history of hemorrhagic brain metastases. Therefore, confirmatory cardiac magnetic resonance (CMR) was obtained and findings were consistent with bland catheter-related thrombus.

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“…Higher risk, larger tumors are more FDG PET avid. For local staging FDG PET has been found useful in determining whether thrombus in the renal vein and inferior vena cava is malignant or “bland” 6 , a distinction that is considered important by some surgeons 7 . In general CT, MRI and bone scan in symptomatic patients are considered sufficient staging studies to clear a patient for surgery.…”

Section: Use Of Pet In Renal Cell Carcinomamentioning

confidence: 99%

PET/Computed Tomography in Renal, Bladder, and Testicular Cancer

Bouchelouche¹,

Choyke²

2015

PET Clinics

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Imaging plays an important role in the clinical management of cancer patients. Hybrid imaging with PET/CT is having a broad impact in oncology, and in recent years PET/CT is beginning to have an impact in uro-oncology as well. In both bladder and renal cancer there is a need to study the efficacy of other tracers than F-18 fluorodeoxyglucose (FDG), particularly tracers with only limited renal excretion. Thus, new tracers are being introduced in these malignancies. This review focuses on the clinical role of FDG and other PET agents in renal, bladder and testicular cancer.

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Tumor Thrombus

Abstract: This study supports results from other smaller studies regarding the usefulness of FDG PET/CT in TT and corroborates the hypothesis that the SUVmax and the patterns of FDG uptake can be helpful for differentiating BT from TT in oncological patients.

Cited by 31 publications

References 21 publications

The Place of FDG PET/CT in Renal Cell Carcinoma: Value and Limitations

The Place of FDG PET/CT in Renal Cell Carcinoma: Value and Limitations

Cardiac Magnetic Resonance for Evaluating Catheter Related FDG Avidity

PET/Computed Tomography in Renal, Bladder, and Testicular Cancer

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