Tumor therapy of neoplastic diseases with tumor cells and neuraminidase

Sedlacek, H.H.; Hagmayer, G.; Seiler, F. R.

doi:10.1007/bf00205649

Cited by 8 publications

(6 citation statements)

References 43 publications

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“…However, one study reported that combining intratumoral injection of BCG cell walls with surgery increased survival time over surgery alone [28]. Another study reported that canine mammary tumor cells treated with neuraminidase and used as a vaccine had antitumor activity in dogs [29].…”

Section: Canine Mammary Neoplasmsmentioning

confidence: 99%

Spontaneous tumors in dogs and cats: Models for the study of cancer biology and treatment

1990

Cancer Metast Rev

326

269

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Spontaneous tumors in dogs and cats are appropriate and valid model tumor systems available for testing cancer therapeutic agents or studying cancer biology. The pet population is a vastly underutilized resource of animals available for study. Dogs and cats develop spontaneous tumors with histopathologic and biologic behavior similar to tumors that occur in humans. The tumors with potential relevance for human cancer biology include osteosarcoma, mammary carcinoma, oral melanoma, oral squamous cell carcinoma, nasal tumors, lung carcinoma, soft tissue sarcomas, and malignant non-Hodgkin's lymphoma. Canine osteosarcoma is a malignant aggressive bone tumor with a 90% metastasis rate after surgical amputation. Its predictable metastatic rate and pattern and its relative resistance to chemotherapy make this tumor particularly attractive for studying anti-metastasis approaches. Canine and feline malignant mammary tumors are fairly common in middle-aged animals and have a metastatic pattern similar to that in women; that is, primarily to regional lymph nodes and lungs. Chemotherapy has been minimally effective, and these tumors may be better models for testing biological response modifiers. Oral tumors, especially melanomas, are the most common canine malignant tumor in the oral cavity. Metastasis is frequent, and the response to chemotherapy and radiation has been disappointing. This tumor can be treated with anti-metastatic approaches or biological response modifiers. Squamous cell carcinomas, especially in the gum, are excellent models for radiation therapy studies. Nasal carcinomas are commonly treated with radiation therapy. They tend to metastasize slowly, but have a high local recurrence rate. This tumor is suitable for studying radiation therapy approaches. Primary lung tumors and soft tissue sarcomas are excellent models for studying combined modality therapy such as surgery with chemotherapy or biological response modifiers. Finally, non-Hodgkin's lymphoma is a common neoplastic process seen in the dog. These tumors respond to combination chemotherapy and have great potential as a model for newer chemotherapeutic agents and biological response modifiers. This paper will further elaborate on the relative merits of each tumor type as a model for human cancer therapy and biology.

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Section: Canine Mammary Neoplasmsmentioning

confidence: 99%

Spontaneous tumors in dogs and cats: Models for the study of cancer biology and treatment

1990

Cancer Metast Rev

326

269

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“…Aqueous ammonia transformed 10 into 13 (0"; J(2,3) = 5.8 Hz, J(3,4) = 3.8 Hz) and, hence, into the addition products (r.t.), which were directly converted into a mixture of the anomeric D-alrro -imines 14 …”

Section: J(34) = 80 Hzmentioning

confidence: 99%

“…In pneumococcal and clostridial infections, high concentrations of sialidases in wounds and body fluids have been found [12] [13]. The role of sialidases -particularly those of Vibrio cholerae -in cancer and cancer therapy is unclear and controversial [14]. Selective inhibition of sialidases might, therefore, be a target for biochemical studies and clinical applications, particularly in view of the preparation of antiviral [ 151, antibacterial, and antiprotozoal drugs.…”

mentioning

confidence: 99%

Synthesis of New Sialidase Inhibitors, 6‐Amino‐6‐Deoxysialic Acids

Baumberger

Vasella

Schauer

1988

Helvetica Chimica Acta

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The synthesis of the 6-amino-6-deoxysialic-acid analogues 4,5, and 6 is described. Mitsunobu reaction of the 1-C-nitroglycal8 (PPh,, HCOOH, DEAD) gave the formiate 10 with inversion of configuration at C(3) (Scheme 2). Treatment of 10 with aq. NH, and subsequent protection of the amino function gave the imines 14 and 15 (Scheme 3 ) , which were transformed into the triflates 17. Substitution by azide, deprotection, and N-acetylation gave the anomeric 2-acetamido-3-azido-I-deoxy-1-nitro-D-mannoses 16 and the enol ether 18. Chain elongation of the nitro azides 16 followed by hydrolysis gave the nonulosonates 20/22, which upon reduction yielded the diols 23 and 24, respectively (Scheme 4 ) . The diol 23 was transformed into the sialic-acid analogues 5, 6, and 32 by ozonolysis, transfer hydrogenation, hydrogenolysis, and deprotection (Scheme 5 ) . and the diol 24 into 4 by a similar reaction sequence. The sialic-acid analogues 4 and 6 inhibit bacterial and viral sialidases competitively. The inhibitor constants for this enzyme from Vibrio cholerae are 0.12 mM for 4 and 0.19 mM for 6, respectively. The activity of fowl plague virus sialidase was reduced by 17% and 36% under the influence of 4 and 6, respectively, at a concentration of 0.1 mM. Compound 5 was inactive. Several sialidase inhibitors are known [16][17][18][19][20], e.g. N-acetyl-2-deoxyneur-2-enaminic acid ('2,3-dehydro-N-acetylneuraminic acid'; Neu2enSAc) [2 11 [22], N-acetyl-2-deoxy-4-epineur-Zenaminic acid (4epiNeu2enSAc) [22] [23], and N-acetyl-2-deoxy-4-oxoneur-2-

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“…Responses were infrequent and transient in nature (Sedlacek et al . , ). In another study, dogs with advanced CMC were treated with autologous tumour cell membranes that had been conjugated to bovine gamma globulins, but progression of disease was unaffected (Hannant et al .…”

Section: Cancer Vaccinesmentioning

confidence: 99%

Immunotherapy for canine cancer – Is it time to go back to the future?

Killick

Stell

Catchpole³

2015

J of Small Animal Practice

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Over the last 50 years, the significance of the immune system in the development and control of cancer has been much debated. However, recent discoveries provide evidence for a role of immunological mechanisms in the detection and destruction of cancer cells. Forty years ago veterinary oncologists were already investigating the feasibility of treating neoplasia by enhancing anticancer immunity. Unfortunately, this research was hindered by lack of a detailed understanding of cancer immunology, this limited the specificity and success of these early approaches. The great forward strides made in our understanding of onco-immunology in recent years have provided the impetus for a resurgence of interest in anticancer immunotherapy for canine patients. In this article both these initial trials and the exciting novel immunotherapeutics currently in development are reviewed.

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Tumor therapy of neoplastic diseases with tumor cells and neuraminidase

Cited by 8 publications

References 43 publications

Spontaneous tumors in dogs and cats: Models for the study of cancer biology and treatment

Spontaneous tumors in dogs and cats: Models for the study of cancer biology and treatment

Synthesis of New Sialidase Inhibitors, 6‐Amino‐6‐Deoxysialic Acids

Immunotherapy for canine cancer – Is it time to go back to the future?

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