Tumor Therapeutic Response and Vessel Tortuosity: Preliminary Report in Metastatic Breast Cancer

Bullitt, Elizabeth; Lin, Nancy U.; Ewend, Matthew G.; Zeng, Donglin; Winer, Eric P.; Carey, Lisa A.; Smith, Jennifer K.

doi:10.1007/11866763_69

Cited by 18 publications

(16 citation statements)

References 11 publications

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“…Our imaging study included all 22 patients (female, age range 31-61, mean age 52 years) who consented to enter the imaging study and for whom an MRA was acquired both at baseline and at month two. An interim report on the imaging study was presented at a computer science conference (12).…”

Section: Patient Groupsmentioning

confidence: 99%

Blood Vessel Morphologic Changes Depicted with MR Angiography during Treatment of Brain Metastases: A Feasibility Study

Bullitt¹,

Lin²,

Ja³

et al. 2007

Radiology

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Purpose-To prospectively determine a) if magnetic resonance angiograms (MRA) can detect intracranial vascular morphological changes during treatment of brain metastases from breast cancer, and b) if serial, quantitative vessel tortuosity measurements might predict tumor treatment response in advance of traditional methods.Materials and Methods-Institutional review board approval and informed consent were obtained in this HIPAA-compliant study. Twenty-two women aged 31-61 underwent brain MRA imaging prior to and two months after initiation of lapatinib therapy for brain metastases from breast cancer. Vessels were extracted from MRA using a computer program. Changes in vessel number, radius, and tortuosity were calculated mathematically, were normalized by values defined from 34 healthy controls (19 females, 15 males, age range 19-72), and were compared to subsequent assessments of tumor volume and clinical course.Results-All tumor patients exhibited abnormal vessel tortuosity at baseline. Nineteen patients (86%) failed to exhibit improvement in vessel tortuosity at month 2 and all demonstrated tumor growth by month 4. Vessel tortuosity measurements correctly predicted treatment failure 1-2 months earlier than traditional methods. Three patients (14%) displayed quantitative improvement in vessel tortuosity at month 2, with dropout of small abnormal vessels and "straightening" of large vessels. The two patients for whom further follow-up was available each responded to treatment for over 6 months.Conclusion-Our results establish the feasibility of using MRA to quantify vessel shape changes during therapy. Although further research is required, results suggest that changes in vessel tortuosity might provide an early prediction of tumor treatment response.

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Section: Patient Groupsmentioning

confidence: 99%

Blood Vessel Morphologic Changes Depicted with MR Angiography during Treatment of Brain Metastases: A Feasibility Study

Bullitt¹,

Lin²,

Ja³

et al. 2007

Radiology

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“…Similar vessel segmentation and analysis methods have been previously implemented for tissue disease and tumor response assessment in magnetic resonance (MR) angiographic data (9,11,14,15). The physics of dualfrequency contrast-enhanced imaging, which enables the acoustic angiographic approach essential to microvessel seg-U ltrasonography (US) is an attractive medical imaging modality because of its relatively low cost, portability, and low level of invasiveness.…”

Section: Animal and Contrast Agent Preparationmentioning

confidence: 99%

Mapping Microvasculature with Acoustic Angiography Yields Quantifiable Differences between Healthy and Tumor-bearing Tissue Volumes in a Rodent Model

Gessner¹,

Aylward²,

Dayton³

2012

Radiology

104

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Purpose:To determine if the morphologies of microvessels could be extracted from contrast material-enhanced acoustic angiographic ultrasonographic (US) images and used as a quantitative basis for distinguishing healthy from diseased tissue. Materials and Methods:All studies were institutional animal care and use committee approved. Three-dimensional contrast-enhanced acoustic angiographic images were acquired in both healthy (n = 7) and tumor-bearing (n = 10) rats. High-spatial-resolution and high signal-to-noise acquisition was enabled by using a prototype dual-frequency US transducer (transmit at 4 MHz, receive at 30 MHz). A segmentation algorithm was utilized to extract microvessel structure from image data, and the distance metric (DM) and the sum of angles metric (SOAM), designed to distinguish different types of tortuosity, were applied to image data. The vessel populations extracted from tumor-bearing tissue volumes were compared against vessels extracted from tissue volumes in the same anatomic location within healthy control animals by using the two-sided Student t test. Results:Metrics of microvascular tortuosity were significantly higher in the tumor population. The average DM of the tumor population (1.34 6 0.40 [standard deviation]) was 23.76% higher than that of the control population (1.08 6 0.08) (P , .0001), while the average SOAM (22.53 6 7.82) was 50.73% higher than that of the control population (14.95 6 4.83) (P , .0001). The DM and SOAM metrics for the control and tumor populations were significantly different when all vessels were pooled between the two animal populations. In addition, each animal in the tumor population had significantly different DM and SOAM metrics relative to the control population (P , .05 for all; P value ranges for DM, 3.89 3 10 27 to 5.63 3 10 23 ; and those for SOAM, 2.42 3 10 212 to 1.57 3 10 23). Conclusion:Vascular network quantification by using high-spatialresolution acoustic angiographic images is feasible. Data suggest that the angiogenic processes associated with tumor development in the models studied result in higher instances of vessel tortuosity near the tumor site. Kruse and Ferrara (16), and the design of the prototype imaging transducer has been previously presented by Gessner et al (17). The purpose of this analysis was to test our hypothesis that the morphologies of microvessels could be extracted from US images and used as a quantitative basis for distinguishing healthy from diseased tissue volumes in a rat model. Materials and Methods Animal and Contrast Agent PreparationAll animal protocols used in this prospective study were approved by our institutional animal care and use committee. Animals used in this prospective study were female Fischer 344 rats (approximately 250 g, Charles River Laboratories, Durham, NC). A fibrosarcoma tumor model was established through the implantation of a 1-mm 3 sample of tissue in the right flank region of the animals as previously described (18). Animals were imaged after the tumor had grown larger than 0.5 cm ...

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“…So far, only 1 group presented useful results on the method of cerebrovascular DSA in mice. 8,13,14,19,20 These results were obtained using a third-generation synchrotron radiation facility (SPring 8). Advantages of using a synchrotron are that it produces a significantly higher photon flux than conventional x-ray sources and the monochromatized x-ray energies just above the iodine K-edge energy produce the highest contrast.…”

Section: Discussionmentioning

confidence: 99%

“…While micro-CTA of the cerebral vasculature in live mice is feasible at high resolutions (16 m)-at the expense of relatively high contrast doses (tail vein injection of 350 L contrast agent over a 40-second scan time) and high radiation doses 9,11 -due to insufficient temporal resolution, micro-CTA and small-animal MRA [12][13][14][15][16] do not yet allow monitoring of the murine cerebrovascular blood flow.…”

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confidence: 99%

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In Vivo X-Ray Digital Subtraction and CT Angiography of the Murine Cerebrovasculature Using an Intra-Arterial Route of Contrast Injection

Figueiredo

Boll

Kramer

et al. 2012

AJNR Am J Neuroradiol

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BACKGROUND AND PURPOSE:Investigation of the anatomy, patency, and blood flow of arterial and venous vessels in small animal models of cerebral ischemia, venous thrombosis, or vasospasm is of major interest. However, due to their small caliber, in vivo examination of these vessels is technically challenging. Using micro-CT, we compared the feasibility of in vivo DSA and CTA of the murine cerebrovasculature using an intra-arterial route of contrast administration.

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Tumor Therapeutic Response and Vessel Tortuosity: Preliminary Report in Metastatic Breast Cancer

Cited by 18 publications

References 11 publications

Blood Vessel Morphologic Changes Depicted with MR Angiography during Treatment of Brain Metastases: A Feasibility Study

Blood Vessel Morphologic Changes Depicted with MR Angiography during Treatment of Brain Metastases: A Feasibility Study

Mapping Microvasculature with Acoustic Angiography Yields Quantifiable Differences between Healthy and Tumor-bearing Tissue Volumes in a Rodent Model

In Vivo X-Ray Digital Subtraction and CT Angiography of the Murine Cerebrovasculature Using an Intra-Arterial Route of Contrast Injection

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