Tumor Therapeutic Modes

Peng, Yuzhong; Li, Yang; Lo, Hang Hong; Law, Betty Yuen Kwan; Wong, Vincent Kam Wai

doi:10.1007/978-981-15-5159-8_6

Cited by 2 publications

(2 citation statements)

References 397 publications

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“…Liver allograft recipient mice in the PD-1 inhibitor-treated group developed rejection within 29 d, suggesting that inhibition of the PD-1/PD-L1 pathway would enhance the recipient immune response to the donor, leading to rejection ( 37 ). Recipient mice treated with PD-L1 inhibitor after liver transplantation showed a high inflammatory response, with phlebitis, biliary intraepithelial lymphocyte infiltration, hepatic congestion, and hemorrhagic injury after 8 d after surgery ( 38 ). Compared with 5 d after surgery, CD8 + T cell infiltration increased in the transplanted liver tissue at 8 d, and the expression of related genes (e. g., granzyme B, FasL, perforin) and inflammatory factors (e.g.…”

Section: Expression Of Pd-1/pd-l1 In Liver Transplantation Tissuementioning

confidence: 99%

Progress of PD-1/PD-L1 signaling in immune response to liver transplantation for hepatocellular carcinoma

et al. 2023

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Primary liver cancer is one of the most common malignant tumors in China. The vast majority of primary liver cancer are hepatocellular carcinoma. Due to its high incidence and mortality from HCC, HCC has always been a feared type of cancer. Liver transplantation, as one of the important means to treat advanced liver cancer, has brought new hope to patients. However, as patients have been in a state of immunosuppression after liver transplantation, these patients face new problems of HCC recurrence and metastasis. A increasing number of studies have proved that blocking the PD-1/PD-L1 signaling pathway and restoring the immune killing inhibition of T cells can produce better therapeutic effects on tumors and chronic infectious diseases. As a promising treatment in the field of tumor immunotherapy, PD-1/PD-L1 inhibitors have achieved important results in liver cancer patients, but their application in liver transplantation patients is still highly controversial. This paper will introduce the mechanism of action of PD-1/PD-L1 signaling pathway and the current basic and clinical studies of PD-1/PD-L1 signaling pathway associated with immune response in HCC transplantation.

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Section: Expression Of Pd-1/pd-l1 In Liver Transplantation Tissuementioning

confidence: 99%

Progress of PD-1/PD-L1 signaling in immune response to liver transplantation for hepatocellular carcinoma

et al. 2023

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“…The cancer cells are subsequently heated and killed by the beam as directed around the tumor. Small tumors inside the breast can occasionally be removed with a laser [30]. Breast cancer can be treated with laser therapy in one of two ways: either as a preoperative procedure to shrink the size and number of cancer cells before surgery or as a postoperative procedure to eradicate any leftover cancer cells after the surgery [31].…”

Section: Figure (2): the Relation Between Pulse Duration And Ablation...mentioning

confidence: 99%

Advancements in Laser and Ultrasound Therapeutic Strategies for Cancer Cells: Recent Review

Rasul,

Abduljabbar,

Khalil

2023

NJES

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Cancer is a disease caused by uncontrollable cell growth and division. Surgery, chemotherapy, radiotherapy, and hormonotherapy are all cancer treatment options. In addition to noninvasive cancer ablative therapy. As an example, ultrasonic therapy, even with low-intensity pulsed ultrasound (LIPUS) or high-intensity focused ultrasound (HIFU), and Laser therapy (photo-biomodulation therapy) in low-level laser therapy (LLLT) with different wavelength ranges from ultraviolet (UV), visible and infrared (IR) that all have demonstrated different results depending on the target of treatment so previous trials therapies are being studied. This paper reviews recent studies on the in vitro treatment effect of ultrasound therapy and laser therapy on normal and cancerous cell lines with specific parameters. The effect of ultrasound results showed a decrease in cell proliferation and an increase in apoptosis in different types of cells, depending especially on sound intensity, known as Special Peak Temporal Average Intensity (ISPTA). While the laser effect is noticed on cell viability, either enhance or inhibit their viability depending upon the dose of exposure and other specific parameters like wavelength, energy density, and power density used in each treatment protocol. The previous studies conclude that each response would have a treatment method with specific parameters, even an increase or decrease in cell viability. Further studies need to be applying these methods in vivo.

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Tumor Therapeutic Modes

Cited by 2 publications

References 397 publications

Progress of PD-1/PD-L1 signaling in immune response to liver transplantation for hepatocellular carcinoma

Progress of PD-1/PD-L1 signaling in immune response to liver transplantation for hepatocellular carcinoma

Advancements in Laser and Ultrasound Therapeutic Strategies for Cancer Cells: Recent Review

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