Tumor targeting potential of liposomes encapsulating GA-67 and antibody to dalton's lymphoma associated antigen (anti-DLAA)

Udayachander, M.; Meenakshi, A.; Muthiah, Rajah; Muthukumaran, S.

doi:10.1016/0360-3016(87)90168-4

Cited by 23 publications

(9 citation statements)

References 20 publications

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“…DL is a T-cell tumor that originates in thymus of DBA strain (H-2 d ) of mice [13,14]. DL can grow in the form of either an ascitic or a solid tumor [15] and has been reported to possess chromosomal aberrations [16]. Like some lymphoma and leukemia of human origin, DL cells do not metastasize to other lymphoid organs [17].…”

Section: Introductionmentioning

confidence: 99%

Gender dimorphism of tumor growth: role of gonadal hormones in differential regulation of apoptosis of a murine T cell lymphoma

Gupta

Singh

2007

J Biomed Sci

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The present investigation was undertaken to study if a gender-dependent differential induction of tumor cell apoptosis is responsible for the manifestation of gender dimorphism observed in the growth of a transplantable murine T cell lymphoma, designated as Dalton's lymphoma (DL). Tumor cell samples obtained from male tumor-bearing mice showed a higher number of cells with apoptotic morphology compared to that observed in female tumor-bearing mice. In this report we demonstrate that male hormone androgen and female hormone estrogen can differentially modulate tumor cell proliferation and apoptosis through alteration in the expression pattern of cell death regulating genes: p53 and CAD. DL cells were shown to express mRNA for androgen and estrogen receptors. Further these gonadal hormones also induced tumor cells to produce tumor growth regulating proteins: VEGF, TGF-beta, IL-2, IL-2R, SOCS, Hsp-70 and IFN-gamma which in turn either through autocrine action on tumor cells or via TAM-derived NO were observed to regulate tumor cell apoptosis leading to gender dimorphism of tumor growth. This study also discusses the possible mechanism involved. The study has clinical significance as these results will helps in understanding the mechanism of gender dimorphism with respect to the progression of T-cells tumors.

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Section: Introductionmentioning

confidence: 99%

Gender dimorphism of tumor growth: role of gonadal hormones in differential regulation of apoptosis of a murine T cell lymphoma

Gupta

Singh

2007

J Biomed Sci

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“…[23] Therefore, in this study, we sought to investigate the effect of chelerythrine on the apoptosis of Dalton's lymphoma (DL), a type of spontaneous murine T-cell lymphoma that has its own unique etiology and is characterized by highly deleterious, invasive, and rapid growth in murine models. [24][25][26][27][28][29][30] …”

Section: Introductionmentioning

confidence: 99%

A benzophenanthridine alkaloid, chelerythrine induces apoptosis in vitro in a Dalton′s lymphoma

et al. 2013

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“…DL was main tained in ascitic form by serial transplantation in C3H/ He mice [8], The mice survived for an average of 25 days after the DL transplantation (2 x 10s cells/mouse in 0.05 ml PBS).…”

Section: Mice and Tumor Systemmentioning

confidence: 99%

“…How ever, to the best of our knowledge, there has been no study on the possible alteration of the immune responses to exogenous antigens in a T cell lymphoma-bearing animal or human hosts. Earlier we reported that Dalton's lym phoma (DL), a spontaneous murine T cell lymphoma [8], alters various functions of macrophages both in vitro and in vivo [9,10], It was, therefore, speculated that the DL growth in vivo might also influence humoral and/or cellular immune responses of the host either directly or through the alteration of the macrophage functions.…”

Section: Introductionmentioning

confidence: 99%

Ascitic Growth of a T Cell Lymphoma in Mice Alters the Humoral and Cellular Immune Response to Exogenous Antigens

Parajuli¹,

Singh²

1997

Tumor Biol

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The effect of the ascitic growth of Dalton’s lymphoma (DL), a T cell lymphoma, on the immune responses of the host mice to exogenous antigens, with respect to the humoral response, delayed-type hypersensitivity (DTH) response and the antigen-presenting ability of macrophages was investigated. The humoral immune response to sheep red blood cells (SRBC) as well as the antigen-presenting ability of macrophages (with keyhole limpet hemocyanin as the standard antigen) in the DL-bearing mice were consistently higher than in the normal mice, although the magnitude showed a decline during later tumor stages. However, the DTH response to SRBC was suppressed in the DL-bearing mice compared with the response in the normal mice. The possible mechanisms are discussed. In vivo administration of FK565, a synthetic biological response modifier, enhanced the humoral immune response as well as the antigen-presenting ability of the macrophages in the normal and early DL-bearing mice, whereas these immune responses n the later tumor-bearing animals were found to be nonresponsive to FK565 treatment. In contrast, the DTH response in the normal as well as in the DL-bearing mice was suppressed on FK565 administration. This is the first study of its kind regarding the effect of the ascitic growth of any T cell lymphoma on various aspects of the immune response to exogenous antigens and the correlation thereof with an immuno-modulator.

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Tumor targeting potential of liposomes encapsulating GA-67 and antibody to dalton's lymphoma associated antigen (anti-DLAA)

Cited by 23 publications

References 20 publications

Gender dimorphism of tumor growth: role of gonadal hormones in differential regulation of apoptosis of a murine T cell lymphoma

Gender dimorphism of tumor growth: role of gonadal hormones in differential regulation of apoptosis of a murine T cell lymphoma

A benzophenanthridine alkaloid, chelerythrine induces apoptosis in vitro in a Dalton′s lymphoma

Ascitic Growth of a T Cell Lymphoma in Mice Alters the Humoral and Cellular Immune Response to Exogenous Antigens

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