Tumor targeting and penetrating biomimetic mesoporous polydopamine nanoparticles facilitate photothermal killing and autophagy blocking for synergistic tumor ablation

Huang, Xueqin; Chen, Lingzhi; Lin, Youping; Tou, Kai Ip; Cai, Huaihong; Jin, Hua; Lin, Wensen; Zhang, Jianglin; Cai, Jun; Zhou, Haibo; Pi, Jiang

doi:10.1016/j.actbio.2021.09.030

Cited by 44 publications

(30 citation statements)

References 49 publications

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“…As a PTA in clinical applications, MPDA has been recognized as a promising carrier for drug delivery due to its high surface area ratio, mesoporous structure, and easy functional modification; it has also been widely used in disease research. Huang et al [ 27 ] fabricated a biomimetic nano-platform by MPDA loading the autophagy inhibitor chloroquine (CQ), which blankets homologous prostate cancer cell membranes (CMs) for homotypic targeting effects. Compared with other groups, the MPDA@CMs-CQ group showed remarkable tumor ablation ability after irradiation.…”

Section: Discussionmentioning

confidence: 99%

Toxicity Analysis of Mesoporous Polydopamine on Intestinal Tissue and Microflora

Xie

Liao

et al. 2022

Molecules

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As a promising therapy, photothermal therapy (PTT) converts near-infrared (NIR) light into heat through efficient photothermal agents (PTAs), causing a rapid increase in local temperature. Considering the importance of PTAs in the clinical application of PTT, the safety of PTAs should be carefully evaluated before their widespread use. As a promising PTA, mesoporous polydopamine (MPDA) was studied for its clinical applications for tumor photothermal therapy and drug delivery. Given the important role that intestinal microflora plays in health, the impacts of MPDA on the intestine and on intestinal microflora were systematically evaluated in this study. Through biological and animal experiments, it was found that MPDA exhibited excellent biocompatibility, in vitro and in vivo. Moreover, 16S rRNA analysis demonstrated that there was no obvious difference in the composition and classification of intestinal microflora between different drug delivery groups and the control group. The results provided new evidence that MPDA was safe to use in large doses via different drug delivery means, and this lays the foundation for further clinical applications.

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Section: Discussionmentioning

confidence: 99%

Toxicity Analysis of Mesoporous Polydopamine on Intestinal Tissue and Microflora

Xie

Liao

et al. 2022

Molecules

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“…Huang et al described mesoporous PDA NPs displaying the ΔT of 30 °C upon irradiation with 0.8 W/cm 2 for 5 min at 808 nm. The system was encapsulated within cancer cell membrane to improve the targeting to the tumor tissue upon intravenous administration [ 117 ]. Semiconducting polymeric NPs are characterized by a photoactivable semiconducting polymeric core, which allows PTT, as well as PA or fluorescent imaging of tumors [ 118 ].…”

Section: Nps-based Pt For Cancer Treatment: Current Statusmentioning

confidence: 99%

Nanoparticles-based phototherapy systems for cancer treatment: Current status and clinical potential

Wang

Fontana

et al. 2023

Bioactive Materials

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“… The mPDA@CMs NPs-CQ could induce significant autophagosome accumulation, ROS generation, mitochondrial damage, endoplasmic reticulum stress, and apoptotic signal transduction, which finally results in synergistic prostate tumor ablation in vivo. [ 174 ] Immunotherapy The BSA-Man@Mn2 + -Ft@Lap nanoagonist induced robust tumor-specific T cell immunity and induced immunogenic apoptosis in tumor cells in vitro. The cooperative cGAS-STING nanoagonist mediated immunostimulation prolongs mouse survival, inhibits distal tumor growth, and reduces lung metastasis [ 175 ] PDT+PTT In vitro studies demonstrated that HER2 and CD44 receptor-mediated dual-targeting strategy could significantly enhance the cellular uptake of GNR-HA −ALA/Cy7.5 -HER2.…”

Section: Pdt And/or Ptt Combined With Immunotherapymentioning

confidence: 99%

Combined Photodynamic and Photothermal Therapy and Immunotherapy for Cancer Treatment: A Review

Kong¹,

Chen²

2022

IJN

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Photoactivation therapy based on photodynamic therapy (PDT) and photothermal therapy (PTT) has been identified as a tumour ablation modality for numerous cancer indications, with photosensitisers and photothermal conversion agents playing important roles in the phototherapy process, especially in recent decades. In addition, the iteration of nanotechnology has strongly promoted the development of phototherapy in tumour treatment. PDT can increase the sensitivity of tumour cells to PTT by interfering with the tumour microenvironment, whereas the heat generated by PTT can increase blood flow, improve oxygen supply and enhance the PDT therapeutic effect. In addition, tumour cell debris generated by phototherapy can serve as tumour-associated antigens, evoking antitumor immune responses. In this review, the research progress of phototherapy, and its research effects in combination with immunotherapy on the treatment of tumours are mainly outlined, and issues that may need continued attention in the future are raised.

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Tumor targeting and penetrating biomimetic mesoporous polydopamine nanoparticles facilitate photothermal killing and autophagy blocking for synergistic tumor ablation

Cited by 44 publications

References 49 publications

Toxicity Analysis of Mesoporous Polydopamine on Intestinal Tissue and Microflora

Toxicity Analysis of Mesoporous Polydopamine on Intestinal Tissue and Microflora

Nanoparticles-based phototherapy systems for cancer treatment: Current status and clinical potential

Combined Photodynamic and Photothermal Therapy and Immunotherapy for Cancer Treatment: A Review

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