Tumor-targeting and imaging micelles for pH-triggered anticancer drug release and combined photodynamic therapy

Qi, Qianqian; Zeng, Xianwu; Peng, Licong; Zhang, Ye; Zhou, Miao; Fu, Jingping; Yuan, Jianchao

doi:10.1080/09205063.2020.1760698

Cited by 10 publications

(4 citation statements)

References 31 publications

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“…106 One example is the encapsulation of Quercetin (Que), a drug for Alzheimer's disease treatment, in Exo by continuous ultrasonic incubation in an ice-water bath. 104 Fluorescence images of C57BL/6 mouse brains show that Exo-Que significantly increases Que accumulation in the brain when compared to free Que, and that Que-Exo is well localized in the brain's hippocampus region. The Exo-Que could attenuate OA-induced neurodegeneration in mice by reducing the apoptosis of neuron cells and improving memory and spatial learning ability.…”

Section: Biomimetic Nanoparticlesmentioning

confidence: 99%

“…For instance, some exosome surfaces are enriched with heat shock protein 70 (HSP70), which has specific binding to endothelial toll-like receptor 4 (TLR4) in the brain to enhance the BBB crossing. 104 The integrin α L β 2 (LFA-1) and α 4 β 1 (VAL-4) on the surface of MV-DEX make it capable of targeting the inflammation in the kidneys. 103 Hence, VAL-4 is also engineered on the surface of C1498-WT cells to target the vascular cell adhesion molecule-1 (VCAM-1), which is upregulated in the inflamed endothelial cells, which indicates that VAL-4 exhibits the crucial function for selective targeting.…”

Section: Other Mechanismsmentioning

confidence: 99%

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‘Passive’ nanoparticles for organ-selective systemic delivery: design, mechanism and perspective

Fu,

Zhang,

Farokhzad

et al. 2023

Chem. Soc. Rev.

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Section: Biomimetic Nanoparticlesmentioning

confidence: 99%

Section: Other Mechanismsmentioning

confidence: 99%

‘Passive’ nanoparticles for organ-selective systemic delivery: design, mechanism and perspective

Fu,

Zhang,

Farokhzad

et al. 2023

Chem. Soc. Rev.

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“…This journal is © The Royal Society of Chemistry 2023 self-assembled approach and previous approaches is that the hostguest and hydrophobic interactions drive the self-assembly process based on small organic molecules. 10 To evaluate the drug-loading and -release capacity of this self-assembled nanocarrier as a controlled-release drug delivery system, we used DOX as the anticancer drug to co-self-assemble with the Ag 2 S QDs and CP6 in PBS (pH 7.4). The encapsulation efficiency and loading efficiency of DOX were 50.7% and 10.2%, respectively.…”

Section: Papermentioning

confidence: 99%

“…[3][4][5][6][7] Combinatorial therapy, which involves using multiple treatment modalities, has been proposed as a method to enhance their complementarity and maximize their strengths to produce synergistic effects. 8,9 Self-assembly approaches using supramolecular This journal is © The Royal Society of Chemistry 2023 concepts are promising strategies for developing delivery nanosystems [10][11][12][13] that can encapsulate quantum dots (QDs) and anticancer drugs for targeted treatment of tumor lesions. However, these approaches face significant challenges such as low stability, resulting in disassembly and payload leakage during the delivery process, uncontrollable drug release in the extracellular matrix of tumor tissue, and low efficiency in cancer treatment.…”

Section: Introductionmentioning

confidence: 99%

Using host–guest interactions at the interface of quantum dots to load drug molecules for biocompatible, safe, and effective chemo-photodynamic therapy against cancer

Yang

Xing

et al. 2023

J. Mater. Chem. B

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Advanced Devices for Tumor Diagnosis and Therapy

Wang

Dai

Lan

et al. 2021

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Chinese mythology says that in the time of the Chou Dynasty ten suns were present in the sky, leading to a hard life for people because of the enormous heat. A hero named "Houyi" At present, tumor diagnosis is performed using common procedures, which are slow, costly, and still presenting difficulties in diagnosing tumors at their early stage. Tumor therapeutic methods also mainly rely on large-scale equipment or non-intelligent treatment approaches. Thus, an early and accurate tumor diagnosis and personalized treatment may represent the best treatment option for a successful result, and the efforts in finding them are still in progress and mainly focusing on non-destructive, integrated, and multiple technologies. These objectives can be achieved with the development of advanced devices and smart technology that represent the topic of the current investigations. Therefore, this review summarizes the progress in tumor diagnosis and therapy and briefly explains the advantages and disadvantages of the described microdevices, finally proposing advanced micro smart devices as the future development trend for tumor diagnosis and therapy.was sent from heaven to shoot down nine suns, leaving only the one that is still shining today to allow a normal life for people (Scheme 1). In real life, cancer threatens people's lives like the nine suns in mythology. The history of the struggle between human beings and tumors is represented by the development of science and technology. The diagnosis of diseases in ancient China by the Chinese medicine used the approach of "observing, listening, asking, and pulse feeling". Observing is referred to as the general inspection of the body and tongue inspection. Listening is referred to listening to sounds and smelling odor. Asking is referred to ask the symptoms. Pulse feeling represents the use of fingers to evaluate the radial artery pulsation behind the wrist, and it represents the essence of the diagnosis by traditional Chinese medicine. It is also the most difficult one among the four diagnostic methods because doctor should determine which organs have lesions from the pulsation changes, which is difficult to perceive by ordinary people. Therefore, without any anatomy support, pulse feeling in the diagnosis of incurable diseases has very large limitations. Pulse feeling can be replaced by intuitive diagnostic techniques in modern medicine. Indeed, tumors are diagnosed in various ways thanks to the development of modern science and technology, and the ever-evolving therapy technology is also transformed into an "arrow of Houyi" to shoot the "poisonous sun" that threatens human health.A timely and accurate diagnosis of cancer is crucial for choosing the correct treatment plan for a consequent successful cure. Usually, the methods to diagnose tumors include imaging, endoscopic investigation, and diagnostic pathology. Pathology techniques are important in clinical diagnosis, but they require biopsy and cannot be monitored in real time. Endoscopic technology allows a direct tumor monitori...

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Tumor-targeting and imaging micelles for pH-triggered anticancer drug release and combined photodynamic therapy

Cited by 10 publications

References 31 publications

‘Passive’ nanoparticles for organ-selective systemic delivery: design, mechanism and perspective

‘Passive’ nanoparticles for organ-selective systemic delivery: design, mechanism and perspective

Using host–guest interactions at the interface of quantum dots to load drug molecules for biocompatible, safe, and effective chemo-photodynamic therapy against cancer

Advanced Devices for Tumor Diagnosis and Therapy

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