Tumor suppressor miR-128-3p inhibits metastasis and epithelial&amp;ndash;mesenchymal transition by targeting ZEB1 in esophageal squamous-cell cancer

Zhao, Lili; Li, Rui; Xu, Shanling; Li, Yang; Zhao, Pei; Dong, Wei; Liu, Zhenjun; Zhao, Qian; Tan, Bo

doi:10.1093/abbs/gmx132

Cited by 60 publications

(39 citation statements)

References 54 publications

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“…We found that MIAT was a direct target of miR‐128‐3p. Previous studies have reported that miR‐128‐3p was a tumor suppressor in hepatocellular carcinoma and esophageal squamous cell carcinoma . Our results showed that the expression of miR‐128‐3p was significantly down‐regulated both in OS tissues and cell lines, which was inversely associated with MIAT expression in OS.…”

Section: Discussionsupporting

confidence: 56%

LncRNA MIAT facilitates osteosarcoma progression by regulating mir‐128‐3p/VEGFC axis

et al. 2019

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The aberrant expression of long non‐coding RNAs (lncRNAs) has been involved in the progression of many human tumors including osteosarcoma (OS). However, the biological function and the underlying mechanism of the lncRNA myocardial infarction‐associated transcript (MIAT) in OS remain unclear. In the present study, we found that lncRNA MIAT was significantly up‐regulated in both OS tissues and cell lines, and high expression of MIAT was positively associated with tumor size and lymph node metastasis of OS patients. In addition, knockdown of MIAT inhibited proliferation, migration, invasion and promoted apoptosis of OS cells in vitro. Moreover, the expression of MIAT was negatively associated with miR‐128‐3p but positively correlated with vascular endothelial growth factor C (VEGFC) in OS. Further mechanistic study revealed that lncRNA MIAT promoted OS progression by up‐regulating VEGFC via sponging miR‐128‐3p in vitro. Taken together, our results suggest that MIAT/miR‐128‐3p/VEGFC axis contributes to OS progression and may be used as a novel therapeutic target for OS. © 2019 IUBMB Life, 9999(9999):1–9, 2019

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Section: Discussionsupporting

confidence: 56%

LncRNA MIAT facilitates osteosarcoma progression by regulating mir‐128‐3p/VEGFC axis

et al. 2019

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“…In vitro studies on the function of ncRNAs in ESCC are generally based on overexpression or knockdown of an ncRNA in ESCC cell lines. Overexpression plasmid or small interfering miRNA mimics and inhibitors are commonly used for transient overexpression or knockdown of miRNAs in ESCC cells [34,52,107]. RNA interference (RNAi), mainly involving siRNA and short hairpin RNA (shRNA), has been widely applied in knockdown of ncRNAs in ESCC cells [18,27,31,80].…”

Section: Experimental Approaches Of Studying Non-coding Rnas In Esccmentioning

confidence: 99%

Emerging Role of Non-Coding RNAs in Esophageal Squamous Cell Carcinoma

Feng

Zhang

Yao

et al. 2019

IJMS

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Esophageal squamous cell carcinoma (ESCC) is a highly prevalent tumor and is associated with ethnicity, genetics, and dietary intake. Non-coding RNAs (ncRNAs), specifically microRNAs (miRNAs), long ncRNAs (lncRNAs), and circular RNAs (circRNAs) have been reported as functional regulatory molecules involved in the development of many human cancers, including ESCC. Recently, several ncRNAs have been detected as oncogenes or tumor suppressors in ESCC progression. These ncRNAs influence the expression of specific genes or their associated signaling pathways. Moreover, interactions of ncRNAs are evident in ESCC, as miRNAs regulate the expression of lncRNAs, and further, lncRNAs and circRNAs function as miRNA sponges to compete with the endogenous RNAs. Here, we discuss and summarize the findings of recent investigations into the role of ncRNAs (miRNAs, lncRNAs, and circRNAs) in the development and progression of ESCC and how their interactions regulate ESCC development.

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“…The forest plots, Begg’s funnel plots, and sensitivity analyses are shown in Supplementary Figures 1 – 8 according to the logic sequencing of miRNA names. For the included 96 studies, 52 were excluded because the frequency of them evaluating prognostic value of miRNA was equal to 1 3 , 4 , 16 , 18 – 23 , 26 , 30 , 31 , 39 – 46 , 48 , 53 , 54 , 56 , 60 , 61 , 64 – 74 , 77 – 86 , 92 – 96 . In addition, although one article reported OS results about miR-193a-5p, it was excluded because it had non-dichotomous miRNA expression value 105 .…”

Section: Resultsmentioning

confidence: 99%

Prognostic Value of MicroRNAs in Esophageal Carcinoma: A Meta-Analysis

Gao

Zhao

Zhang

et al. 2018

Clinical and Translational Gastroenterology

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BackgroundNumerous articles have reported that abnormal expression levels of microRNAs (miRNAs) are related to the survival times of esophageal carcinoma (EC) patients, which contains esophageal adenocarcinoma (EAC) and esophageal squamous cell carcinoma (ESCC). Nevertheless, there has not been a comprehensive meta-analysis to assess the accurate prognostic value of miRNAs in EC.MethodsStudies published in English up to April 12, 2018 that evaluated the correlation of the expression levels of miRNAs with overall survival (OS) in EC were identified by online searches in PubMed, EMBASE, Web of Science, and the Cochrane Database of Systematic Reviews performed by two independent authors. The pooled hazard ratios (HRs) with 95% confidence intervals (CIs) were used to estimate the correlation between OS and miRNA expression. HR ≥ 2 was considered cutoff for considering the miRNA as prognostic candidate.ResultsForty-four pertinent articles with 22 miRNAs and 4310 EC patients were ultimately included. EC patients with tissue expression levels of high miR-21 or low miR-133a (HR = 2.48, 95% CI = 1.50–4.12), miR-133b (HR = 2.15, 95% CI = 1.27–3.62), miR-138 (HR = 2.27, 95% CI = 1.68–3.08), miR-203 (HR = 2.83, 95% CI = 1.35–5.95), miR-375 and miR-655 (HR = 2.66, 95% CI = 1.16–6.12) had significantly poorer OS (P < 0.05). In addition, EC patients with blood expression levels of high miR-21 (HR = 2.19, 95% CI = 1.31–3.68) and miR-223 had significantly shorter OS (P < 0.05).ConclusionsIn conclusion, tissue expression levels of miR-21, miR-133a, miR-133b, miR-138, miR-203, miR-375, and miR-655 and blood expression levels of miR-21 and miR-223 demonstrate significant prognostic value. Among them, the expression levels of miR-133a, miR-133b, miR-138, miR-203, and miR-655 in tissue and the expression level of miR-21 in blood are potential prognostic candidates for predicting OS in EC.

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Tumor suppressor miR-128-3p inhibits metastasis and epithelial–mesenchymal transition by targeting ZEB1 in esophageal squamous-cell cancer

Cited by 60 publications

References 54 publications

LncRNA MIAT facilitates osteosarcoma progression by regulating mir‐128‐3p/VEGFC axis

LncRNA MIAT facilitates osteosarcoma progression by regulating mir‐128‐3p/VEGFC axis

Emerging Role of Non-Coding RNAs in Esophageal Squamous Cell Carcinoma

Prognostic Value of MicroRNAs in Esophageal Carcinoma: A Meta-Analysis

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