Tumor suppressor in lung cancer 1 (TSLC1), a novel tumor suppressor gene, is implicated in the regulation of proliferation, invasion, cell cycle, apoptosis, and tumorigenicity in cutaneous squamous cell carcinoma

Liu, Dong; Feng, Xing; Wu, Ximei; Li, Zhanguo; Wang, Wanling; Tao, Yipeng; Xia, Yonghua

doi:10.1007/s13277-013-0961-2

Cited by 22 publications

(25 citation statements)

References 40 publications

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“…In Kaplan-Meier survival analysis, we found that the overall survival (OS) of CADM1/TSLC1 negative group was significantly lower than that in CADM1/TSLC1 positive group, which was consistent with the results in other studies of esophageal squamous cell carcinoma (ESCC) [ 14 ], as well as skin squamous cell carcinoma [ 20 ], laryngeal carcinoma [ 13 ], meningioma [ 21 ], breast cancer [ 22 ], nasopharyngeal carcinoma (NPC) [ 23 ], lung adenocarcinoma [ 9 ], and colon cancer [ 12 ]. Furthermore, our results suggested that CADM1/TSLC1 negative expression was associated with shorter disease-free survival (DFS) and accordingly might predict early relapse of patients with ESCC after surgery.…”

Section: Discussionsupporting

confidence: 90%

Loss of CADM1/TSLC1 Expression Is Associated with Poor Clinical Outcome in Patients with Esophageal Squamous Cell Carcinoma

Zeng

Zheng

et al. 2016

Gastroenterology Research and Practice

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Aims. We sought to determine the relationship between CADM1/TSLC1 expression and clinicopathological characteristics in patients with esophageal squamous cell carcinoma (ESCC) and the correlation with survival. Materials and Methods. Two hundred and ninety-three ESCC tissues and paired adjacent normal esophageal tissues were immunohistochemically assessed in this study. The association of CADM1/TSLC1 with clinicopathological parameters, as well as disease-free survival (DFS) and overall survival (OS), was determined based on the Kaplan-Meier method and Cox regression models. Results. CADM1/TSLC1 was detected in 236 (80.5%) tumor tissues and 19 (8.0%) paired adjacent normal esophageal tissues. Decreased CADM1/TSLC1 expression was correlated with more advanced histological grade. CADM1/TSLC1 negative tumors were more frequently observed in male cases than in female cases. DFS and OS in the CADM1/TSLC1 negative group were significantly shorter than those in the positive group, particularly in male patients with ESCC. Conclusion. Loss or reduction of CADM1/TSLC1 expression is associated with more advanced histological grade and predicts early recurrence and short survival duration. Thus, loss of CADM1/TSLC1 could be a prognostic factor that can be used to assess the risk of recurrence and survival.

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Section: Discussionsupporting

confidence: 90%

Loss of CADM1/TSLC1 Expression Is Associated with Poor Clinical Outcome in Patients with Esophageal Squamous Cell Carcinoma

Zeng

Zheng

et al. 2016

Gastroenterology Research and Practice

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“…TSLC1 has been reported as a tumor suppressor gene that is involved in multiple cellular processes such as cell proliferation, differentiation, migration, and invasion [26, 27]. Tsujiuchi et al reported that in HCC induced by N-nitrosodiethylamine, the 5’ upstream region of TSLC1 was methylated and its expression was reduced [18].…”

Section: Discussionmentioning

confidence: 99%

MicroRNA-873 Promotes Cell Proliferation, Migration, and Invasion by Directly Targeting TSLC1 in Hepatocellular Carcinoma

Han¹,

Zhang²,

Ni³

et al. 2018

Cell Physiol Biochem

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Background/Aims: Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer and has the third highest mortality rate among all cancers. MicroRNAs are a class of endogenous, single-stranded short noncoding RNAs. The purpose of this study was to study the role of microRNA-873 in HCC. Methods: The expression of miRNA-873 and tumor suppressor in lung cancer 1 (TSLC1) in HCC tissues and cell lines was detected by real-time quantitative RT-PCR (RT-qPCR) or western blot. A CCK-8 assay was used to examine cell proliferation; flow cytometry was used to assess the cell cycle; the Transwell migration assay was used to test for metastasis. Luciferase assays were performed to assess whether TSLC1 was a novel target of miRNA-873. Results: We showed that miRNA-873 was upregulated in HCC tissues and cell lines compared with the normal control. Knockdown of miRNA-873 inhibited the growth and metastasis of HepG2 and accelerated G1 phase arrest, while overexpression of miRNA-873 had the opposite effect. The dual-luciferase reporter assays revealed that TSLC1 was a novel target of miRNA-873. Further study showed that TSLC1 was decreased in HCC tissues and cell lines. There was a negative correlation between the expression levels of TSLC1 and miRNA-873. The effect of miRNA-873 overexpression was neutralized by TSLC1. We also found that miRNA-873 activated the PI3K/AKT/mTOR signaling pathway and promoted HCC. Conclusions: Our data demonstrated that miRNA-873 promoted HCC progression by targeting TSLC1 and provided a new target for the therapy of HCC.

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“…Mutations in HRAS, KRAS, and EGFR have also been detected in cSCC, emphasizing the role of EGFR and extracellular signal-regulated kinase 1/2 (ERK1/2) signaling in development of cSCC (Ratushny et al, 2012). Recently, previously unreported markers for progression of cSCC have been identified and characterized (Farshchian et al, 2011(Farshchian et al, , 2015Liu et al, 2013;Riihilä et al, 2014Riihilä et al, , 2015Trimmer et al, 2012), but understanding of the molecular basis of cSCC progression from premalignant lesion (actinic keratosis, AK) to cSCC in situ (cSCCIS) and eventually to invasive cSCC remains incomplete.…”

Section: Introductionmentioning

confidence: 99%

Long Noncoding RNA PICSAR Promotes Growth of Cutaneous Squamous Cell Carcinoma by Regulating ERK1/2 Activity

Piipponen

Nissinen

Farshchian

et al. 2016

Journal of Investigative Dermatology

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Keratinocyte-derived cutaneous squamous cell carcinoma (cSCC) is the most common metastatic skin cancer, and its incidence is increasing globally. Long noncoding RNAs (lncRNA) are involved in various biological processes, and their role in cancer progression is emerging. Whole transcriptome analysis of cSCC cells (n = 8) and normal human epidermal keratinocytes (n = 4) revealed overexpression of long intergenic ncRNA (LINC00162) in cSCC cells. The expression of LINC00162 in cSCC cells was upregulated by inhibition of the p38α and p38δ mitogen-activated protein kinases. Analysis of tissue sections by RNA in situ hybridization showed that LINC00162 is specifically expressed by tumor cells in cSCCs but not by keratinocytes in normal skin in vivo. Knockdown of LINC00162 inhibited proliferation and migration of cSCC cells, and suppressed the growth of human cSCC xenografts in vivo. Furthermore, knockdown of LINC00162 inhibited extracellular signal-regulated kinase 1/2 activity and upregulated expression of dual specificity phosphatase 6 (DUSP6) in cSCC cells. Based on these observations, LINC00162 was named p38 inhibited cutaneous squamous cell carcinoma associated lincRNA (PICSAR). Our results provide mechanistic evidence for the role of PICSAR in promoting cSCC progression via activation of extracellular signal-regulated kinase 1/2 signaling pathway by downregulating DUSP6 expression. These results also identify PICSAR as a biomarker and putative therapeutic target in cSCC.

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Tumor suppressor in lung cancer 1 (TSLC1), a novel tumor suppressor gene, is implicated in the regulation of proliferation, invasion, cell cycle, apoptosis, and tumorigenicity in cutaneous squamous cell carcinoma

Cited by 22 publications

References 40 publications

Loss of CADM1/TSLC1 Expression Is Associated with Poor Clinical Outcome in Patients with Esophageal Squamous Cell Carcinoma

Loss of CADM1/TSLC1 Expression Is Associated with Poor Clinical Outcome in Patients with Esophageal Squamous Cell Carcinoma

MicroRNA-873 Promotes Cell Proliferation, Migration, and Invasion by Directly Targeting TSLC1 in Hepatocellular Carcinoma

Long Noncoding RNA PICSAR Promotes Growth of Cutaneous Squamous Cell Carcinoma by Regulating ERK1/2 Activity

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