Tumor suppressor gene E-cadherin and its role in normal and malignant cells

Pećina‐Šlaus, Nives

doi:10.1186/1475-2867-3-17

Cited by 323 publications

(129 citation statements)

References 44 publications

Supporting

Mentioning

127

Contrasting

Unclassified

Order By: Relevance

“…E-Cadherin downregulation in cancer cells often occurs as a result of promoter methylation. The dissolution of adherens junctions is a critical step of EMT, with loss/decrease or relocalization of CDH1 as the most commonly used determinant of the EMT phenotype [72,73,74,75,76]. …”

Section: The Clues Of Epithelial-mesenchymal Transitionmentioning

confidence: 99%

The Roles of Epithelial-to-Mesenchymal Transition (EMT) and Mesenchymal-to-Epithelial Transition (MET) in Breast Cancer Bone Metastasis: Potential Targets for Prevention and Treatment

Demirkan

2013

JCM

View full text Add to dashboard Cite

Many studies have revealed molecular connections between breast and bone. Genes, important in the control of bone remodeling, such as receptor activator of nuclear kappa (RANK), receptor activator of nuclear kappa ligand (RANKL), vitamin D, bone sialoprotein (BSP), osteopontin (OPN), and calcitonin, are expressed in breast cancer and lactating breast. Epithelial-mesenchymal transition (EMT) and mesenchymal-epithelial transition (MET) effectors play critical roles during embryonic development, postnatal growth, and epithelial homeostasis, but also are involved in a number of pathological conditions, including wound repair, fibrosis, inflammation, as well as cancer progression and bone metastasis. Transforming growth factor β (TGFβ), insulin-like growth factor I & II (IGF I & II), platelet-derived growth factor (PDGF), parathyroid hormone-related protein (PTH(rP)), vascular endothelial growth factor (VEGF), epithelial growth factors II/I (ErbB/EGF), interleukin 6 (IL-6), IL-8, IL-11, IL-1, integrin αvβ3, matrix metalloproteinases (MMPs), catepsin K, hypoxia, notch, Wnt, bone morphogenetic proteins (BMP), and hedgehog signaling pathways are important EMT and MET effectors identified in the bone microenviroment facilitating bone metastasis formation. Recently, Runx2, an essential transcription factor in the regulation of mesenchymal cell differentiation into the osteoblast lineage and proper bone development, is also well-recognized for its expression in breast cancer cells promoting osteolytic bone metastasis. Understanding the precise mechanisms of EMT and MET in the pathogenesis of breast cancer bone metastasis can inform the direction of therapeutic intervention and possibly prevention.

show abstract

Section: The Clues Of Epithelial-mesenchymal Transitionmentioning

confidence: 99%

The Roles of Epithelial-to-Mesenchymal Transition (EMT) and Mesenchymal-to-Epithelial Transition (MET) in Breast Cancer Bone Metastasis: Potential Targets for Prevention and Treatment

Demirkan

2013

JCM

View full text Add to dashboard Cite

show abstract

“…64 Importantly, E-cadherin plays a key role in epithelial cell polarity maintenance and acts as a potent tumor suppressor by firmly adhering adjacent epithelial cells, preventing their migration and invasion of other tissues. 65,66 E-cadherin loss is considered a hallmark of epithelial-mesenchymal transition (EMT). EMT is a mechanism intended to form mesenchymal cells in injured tissues; however, it can initiate invasive and metastatic behavior in epithelial cancers.…”

Section: Adherens Junction Signaling and Function During Pmn Transepimentioning

confidence: 99%

Epithelial adhesion molecules and the regulation of intestinal homeostasis during neutrophil transepithelial migration

Sumagin¹,

Parkos

2014

Tissue Barriers

View full text Add to dashboard Cite

Epithelial adhesion molecules play essential roles in regulating cellular function and maintaining mucosal tissue homeostasis. Some form epithelial junctional complexes to provide structural support for epithelial monolayers and act as a selectively permeable barrier separating luminal contents from the surrounding tissue. Others serve as docking structures for invading viruses and bacteria, while also regulating the immune response. They can either obstruct or serve as footholds for the immune cells recruited to mucosal surfaces. Currently, it is well appreciated that adhesion molecules collectively serve as environmental cue sensors and trigger signaling events to regulate epithelial function through their association with the cell cytoskeleton and various intracellular adapter proteins. Immune cells, particularly neutrophils (PMN) during transepithelial migration (TEM), can modulate adhesion molecule expression, conformation, and distribution, significantly impacting epithelial function and tissue homeostasis. This review discusses the roles of key intestinal epithelial adhesion molecules in regulating PMN trafficking and outlines the potential consequences on epithelial function.

show abstract

“…34) Class I suppressor gene products play direct roles in cellcycle checkpoint, protein degradation, tumor cell adhesion, and DNA repair. [35][36][37] For example, E-cadherin is associated with adherence to the calcium-dependent epithelial cell-cell junction, and thus loss of its function can lead to cancer metastasis. 36) Class II suppressor gene products play roles similar to class I cancer suppressor gene products in cancer suppression, but class II suppressor genes are not usually mutated, and expression of them is regulated by certain of the class I suppressor gene products.…”

Section: Discussionmentioning

confidence: 99%

“…[35][36][37] For example, E-cadherin is associated with adherence to the calcium-dependent epithelial cell-cell junction, and thus loss of its function can lead to cancer metastasis. 36) Class II suppressor gene products play roles similar to class I cancer suppressor gene products in cancer suppression, but class II suppressor genes are not usually mutated, and expression of them is regulated by certain of the class I suppressor gene products. Certain of the class I suppressor gene products coordinately regulate the expression of several class II suppressor genes as transcription regulators.…”

Section: Discussionmentioning

confidence: 99%