Tumor-suppressive miR-29c binds to MAPK1 inhibiting the ERK/MAPK pathway in pancreatic cancer

Si, Hongtao; Zhang, Ning; Shi, Chang; Luo, Zhanjiang; Hou, Senlin

doi:10.1007/s12094-022-02991-9

Cited by 2 publications

(2 citation statements)

References 28 publications

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“…Downregulation of miR-29c was detected in clinical PDAC tissues, and this miRNA showed an antitumor function by inhibiting integrin subunit β1 [55]. A recent study showed that miR-29c targets MAPK1 to suppress activation of the ERK/MAPK pathway [56].…”

Section: Discussionmentioning

confidence: 98%

Coronin 1C, Regulated by Multiple microRNAs, Facilitates Cancer Cell Aggressiveness in Pancreatic Ductal Adenocarcinoma

Fukuda

Seki

Yasudome

et al. 2023

Genes

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Coronin proteins are actin-related proteins containing WD repeat domains encoded by seven genes (CORO1A, CORO1B, CORO1C, CORO2A, CORO2B, CORO6, and CORO7) in the human genome. Analysis of large cohort data from The Cancer Genome Atlas revealed that expression of CORO1A, CORO1B, CORO1C, CORO2A, and CORO7 was significantly upregulated in pancreatic ductal adenocarcinoma (PDAC) tissues (p < 0.05). Moreover, high expression of CORO1C and CORO2A significantly predicted the 5 year survival rate of patients with PDAC (p = 0.0071 and p = 0.0389, respectively). In this study, we focused on CORO1C and investigated its functional significance and epigenetic regulation in PDAC cells. Knockdown assays using siRNAs targeting CORO1C were performed in PDAC cells. Aggressive cancer cell phenotypes, especially cancer cell migration and invasion, were inhibited by CORO1C knockdown. The involvement of microRNAs (miRNAs) is a molecular mechanism underlying the aberrant expression of cancer-related genes in cancer cells. Our in silico analysis revealed that five miRNAs (miR-26a-5p, miR-29c-3p, miR-130b-5p, miR-148a-5p, and miR-217) are putative candidate miRNAs regulating CORO1C expression in PDAC cells. Importantly, all five miRNAs exhibited tumor-suppressive functions and four miRNAs except miR-130b-5p negatively regulated CORO1C expression in PDAC cells. CORO1C and its downstream signaling molecules are potential therapeutic targets in PDAC.

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Section: Discussionmentioning

confidence: 98%

Coronin 1C, Regulated by Multiple microRNAs, Facilitates Cancer Cell Aggressiveness in Pancreatic Ductal Adenocarcinoma

Fukuda

Seki

Yasudome

et al. 2023

Genes

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“…Several miRNAs have been suggested to regulate the expression of oncogenes or tumour suppressing genes which ultimately either positively or negatively contribute towards tumour development [ 81 ]. For example, downregulated miR-29c was found in PDAC tissues and was associated with upregulated MAPK1 and resulted in increased cell proliferation, and invasion through activating the downstream MAPK/ERK pathway [ 50 ]. Similarly, downregulated expression of miR-98-5p was shown to lead to upregulated MAP4K4 which promoted cell proliferation, invasion, and migration of PDAC cells in vitro by promoting MAPK/ERK signalling [ 56 ].…”

Section: Mirna Effects On Cell Proliferation and Cell Cycle Progressionmentioning

confidence: 99%

miRNAs in pancreatic cancer progression and metastasis

Mok,

Chitty,

Cox

2024

Clin Exp Metastasis

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Small non-coding RNA or microRNA (miRNA) are critical regulators of eukaryotic cells. Dysregulation of miRNA expression and function has been linked to a variety of diseases including cancer. They play a complex role in cancers, having both tumour suppressor and promoter properties. In addition, a single miRNA can be involved in regulating several mRNAs or many miRNAs can regulate a single mRNA, therefore assessing these roles is essential to a better understanding in cancer initiation and development. Pancreatic cancer is a leading cause of cancer death worldwide, in part due to the lack of diagnostic tools and limited treatment options. The most common form of pancreatic cancer, pancreatic ductal adenocarcinoma (PDAC), is characterised by major genetic mutations that drive cancer initiation and progression. The regulation or interaction of miRNAs with these cancer driving mutations suggests a strong link between the two. Understanding this link between miRNA and PDAC progression may give rise to novel treatments or diagnostic tools. This review summarises the role of miRNAs in PDAC, the downstream signalling pathways that they play a role in, how these are being used and studied as therapeutic targets as well as prognostic/diagnostic tools to improve the clinical outcome of PDAC.

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Tumor-suppressive miR-29c binds to MAPK1 inhibiting the ERK/MAPK pathway in pancreatic cancer

Cited by 2 publications

References 28 publications

Coronin 1C, Regulated by Multiple microRNAs, Facilitates Cancer Cell Aggressiveness in Pancreatic Ductal Adenocarcinoma

Coronin 1C, Regulated by Multiple microRNAs, Facilitates Cancer Cell Aggressiveness in Pancreatic Ductal Adenocarcinoma

miRNAs in pancreatic cancer progression and metastasis

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