Tumor suppressive microRNA-133a regulates novel targets: Moesin contributes to cancer cell proliferation and invasion in head and neck squamous cell carcinoma

Kinoshita, Takashi; Nohata, Nijiro; Fuse, Miki; Hanazawa, Toyoyuki; Kikkawa, Naoko; Fujimura, Lisa; Watanabe-Takano, Haruko; Yamada, Yasuaki; Yoshino, Hirofumi; Enokida, Hideki; Nakagawa, Masayuki; Okamoto, Yoshitaka; Seki, Naohiko

doi:10.1016/j.bbrc.2012.01.030

Cited by 55 publications

(40 citation statements)

References 32 publications

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“…Indeed, lower numbers of Tregs in cancer patients have been observed to correlate with better responses to chemotherapy (37), and multiple experiments suggest that therapeutically targeting Tregs promotes antitumor immunity and tumor rejection in mouse models of cancer (38). Moreover, analyses of moesin levels in tumors also correlate with poor prognosis of many cancers (39)(40)(41).…”

Section: Methodsmentioning

confidence: 99%

Membrane-organizing protein moesin controls Treg differentiation and antitumor immunity via TGF-β signaling

Ansa-Addo¹,

Zhang²,

Yang³

et al. 2017

Journal of Clinical Investigation

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Section: Methodsmentioning

confidence: 99%

Membrane-organizing protein moesin controls Treg differentiation and antitumor immunity via TGF-β signaling

Ansa-Addo¹,

Zhang²,

Yang³

et al. 2017

Journal of Clinical Investigation

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“…Increased expression of miR-1/-133a is associated with t(14;16) translocation multiple myeloma [152] , whilst reduced expression is associated with prostate cancer [102] and RCC [138] , respectively. Reduced expression of other myomiR combinations is also associated with TSCC [111] , ESCC [132] , HNSCC [114,143] , GIST [281] , bladder cancer (TCC) [93] , lung cancer [85,99] , colorectal cancer [86,87] and rhabdomyosarcoma [88] . downregulated and upregulated myomiRs respectively, and Table 6 lists validated myomiR targets related to enhanced cancer progression.…”

Section: Myomirs and Cancermentioning

confidence: 99%

“…Moesin, a member of the ezrinradixinmoesin protein family which links functionally between the plasma membrane and the actin-based cytoskeleton of cells and is found in invadopodia of metastatic cells [142] , is deregulated in HNSCC, breast cancer, CRC, and prostate cancer. In HNSCC cells both miR133a/133b target moesin specifically, and restoration of miR-133b levels in HNSCC cells, as well as in PC10 and H157 lung SCC cell lines, reduces moesin expression, inhibits cell proliferation, cell migration and invasion [143] . The phenotype is also associated with elevation of other miR133 targets such as ARPC5 and GSTP1 [115] .…”

Section: Other Pleiotropic Pathwaysmentioning

confidence: 99%

Roles of the canonical myomiRs miR-1, -133 and -206 in cell development and disease

Mitchelson¹

2015

WJBC

136

132

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MicroRNAs are small non-coding RNAs that participate in different biological processes, providing subtle combinational regulation of cellular pathways, often by regulating components of signalling pathways. Aberrant expression of miRNAs is an important factor in the development and progression of disease. The canonical myomiRs (miR-1, -133 and -206) are central to the development and health of mammalian skeletal and cardiac muscles, but new findings show they have regulatory roles in the development of other mammalian non-muscle tissues, including nerve, brain structures, adipose and some specialised immunological cells. Moreover, the deregulation of myomiR expression is associated with a variety of different cancers, where typically they have tumor suppressor functions, although examples of an oncogenic role illustrate their diverse function in different cell environments. This review examines the involvement of the related myomiRs at the crossroads between cell development/ tissue regeneration/tissue inflammation responses, and cancer development. Core tip: The roles of the canonical muscle-associated microRNAs are reviewed, including microRNA families miR-1 and miR-133, and single miR-206, which are collectively known as the "myomiRs". The myomiRs act at the crossroads of the molecular regulation of muscle cells, linking between pathways for cell differentiation, development and maintenance, but also potentiate aberrant cell growth in numerous non-muscle cancers. Typically myomiRs are downregulated in cancers, but some myomiRs are upregulated in a few cancers, yet each dysregulation event advances tumor progression. The review examines normal and disease-linked molecular changes associated with the myomiRs, and collates the extensive literature into accessible tables. REVIEW

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“…Recently, we sequentially identified tumor suppressive miRNAs in several types of cancers, such as head and neck squamous cell carcinoma, 9,10 esophageal squamous cell carcinoma, 11 bladder cancer, 12,13 renal cell carcinoma 14 and PCa 15 and described the molecular pathways they regulate. Our analysis of miRNA-regulated cancer pathways provided novel insights for diagnostic and therapeutic strategies for these cancers.…”

Section: Introductionmentioning

confidence: 99%

Tumor suppressive microRNAs (miR-222 and miR-31) regulate molecular pathways based on microRNA expression signature in prostate cancer

et al. 2012

Self Cite

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microRNAs (miRNAs) have key roles in human tumorigenesis, tumor progression and metastasis. miRNAs are aberrantly expressed in many human cancers and can function as tumor suppressors or oncogenes that target many cancer-related genes. This study seeks to identify novel miRNA-regulated molecular pathways in prostate cancer (PCa). The miRNA expression signature in clinical specimens of PCa showed that 56 miRNAs were significantly downregulated in PCa compared with nonPCa tissues. We focused on the top four downregulated miRNAs (miR-187, miR-205, miR-222 and miR-31) to investigate their functional significance in PCa cells. Expression levels of these four miRNAs were validated in PCa specimens (15 PCa tissues and 17 non-PCa tissues) to confirm that they were significantly reduced in these PCa tissues. Gain-of-function analysis demonstrated that miR-222 and miR-31 inhibited cell proliferation, invasion and migration in PCa cell lines (PC3 and DU145), suggesting that miR-222 and miR-31 may act as tumor suppressors in PCa. Genome-wide gene expression analysis using miR-222 or miR-31 transfectants to identify the pathways they affect showed that many cancer-related genes are regulated by these miRNAs in PC3 cells. Identification and categorization of the molecular pathways regulated by tumor suppressive miRNAs could provide new information about the molecular mechanisms of PCa tumorigenesis.

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Tumor suppressive microRNA-133a regulates novel targets: Moesin contributes to cancer cell proliferation and invasion in head and neck squamous cell carcinoma

Cited by 55 publications

References 32 publications

Membrane-organizing protein moesin controls Treg differentiation and antitumor immunity via TGF-β signaling

Membrane-organizing protein moesin controls Treg differentiation and antitumor immunity via TGF-β signaling

Roles of the canonical myomiRs miR-1, -133 and -206 in cell development and disease

Tumor suppressive microRNAs (miR-222 and miR-31) regulate molecular pathways based on microRNA expression signature in prostate cancer

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