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SE hijacking.
TFs increase in expression and overexpression, leading to pathological gene activation Cell growth, proliferation, transdifferentiation | Isoxazole (ISX-9) | [ 175 ] | NB | — | SH-SY5Y (subclone with adrenergic (ADRN) phenotype) derived from SK-N-SH cells, 5 CD133-primary samples (2/5 had an isogenic pair of ADRN phenotype), SH-EP2 (subclone with undifferentiated mesenchymal (MES) phenotype) derived from SK-N-SH cells, 3 CD133+ primary samples (all with an isogenic pair of ADRN phenotype) | — | (1) DBH , CHGA , DLK1 (2) ASCL1 , EYA1 , GATA3 , HAND1 , SIX3 ( ZNF536 , PHOX2A , KLF13 , SOX11 , GATA2 , KLF7 , TFAP2B , ISL1 , HEY1 , DACH1 , PHOX2B , PBX3 , SATB1 ) (3) WNT5A , IGFBP2 , FN1 , IL13RA1 (4) MEOX1 , MEOX2 , SIX1 , SIX4 , SOX9 , SMAD3 WWTR1 ( PRRX1 , CREG1 , ELK4 , DCAF6 , ID1 , MAML2 , NOTCH2 , CBFB , IFI16 , ZNF217 , EGR3 , ZFP36L1 ABEP1 ) | (1) known markers of adrenergic differentiation (2) 18 ADRN-specific TFs. Although PHOX2B and PHOX2A are ADRN-specific, SEs associated with them are also found in some MES lines. |
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