Tumor suppressing role of serum-derived exosomal microRNA-15a in osteosarcoma cells through the GATA binding protein 2/murine double minute 2 axis and the p53 signaling pathway

Wu, Chunyu; Li, Zhigang; Feng, Guang; Wang, Liqin; Xie, Juan; Yang, Jin; Wang, Long; Liu, Songjiang

doi:10.1080/21655979.2021.1987092

Cited by 13 publications

(14 citation statements)

References 40 publications

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“…Wu et al found that exosomal miR-15a expression decreased in plasma EVs, and exosomal miR-15a was absorbed by OS cells, which suppressed GATA2/MDM2 signaling via the p53 pathway. This inhibited OS cell growth and migration in vitro (104). Major exosome release process in OS.…”

Section: Extracellular Vesicles Are Involved In Osteosarcoma Prolifer...mentioning

confidence: 96%

Extracellular vesicles: A new diagnostic biomarker and targeted drug in osteosarcoma

Gao

2022

Front. Immunol.

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Osteosarcoma (OS) is a primary bone cancer that is highly prevalent among adolescents and adults below the age of 20 years. The prognostic outcome of metastatic OS or relapse is extremely poor; thus, developing new diagnostic and therapeutic strategies for treating OS is necessary. Extracellular vesicles (EVs) ranging from 30–150 nm in diameter are commonly produced in different cells and are found in various types of body fluids. EVs are rich in biologically active components like proteins, lipids, and nucleic acids. They also strongly affect pathophysiological processes by modulating the intercellular signaling pathways and the exchange of biomolecules. Many studies have found that EVs influence the occurrence, development, and metastasis of osteosarcoma. The regulation of inflammatory communication pathways by EVs affects OS and other bone-related pathological conditions, such as osteoarthritis and rheumatoid arthritis. In this study, we reviewed the latest findings related to diagnosis, prognosis prediction, and the development of treatment strategies for OS from the perspective of EVs.

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Section: Extracellular Vesicles Are Involved In Osteosarcoma Prolifer...mentioning

confidence: 96%

Extracellular vesicles: A new diagnostic biomarker and targeted drug in osteosarcoma

Gao

2022

Front. Immunol.

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“…MiR-15a is located at 13q14.3 of the human genome, and acts as a tumor suppressor in different types of cancers ( Huang et al, 2015 ; Liu et al, 2019a ; Wu et al, 2021 ). In HCC, MSCs-derived exosomes transferred miR-15a to target cells and then suppressed proliferation, migration, and invasion of tumor cells via inhibiting the expression of spalt like transcription factor 4 (SALL4) ( Ma et al, 2021 ).…”

Section: Exosomal Microrna In Osteosarcomamentioning

confidence: 99%

“…Further assays showed that serum-derived exosomes with miR-15a can be internalized by osteosarcoma cells and then miR-15a directly binds to GATA binding protein 2 (GATA2) to inhibit its expression. Since GATA2 can induce the transcription of murine double minute 2 (MDM2) to suppress the p53 signaling pathway, serum-derived exosomal miR-15a can promote apoptosis and cell cycle arrests of osteosarcoma cells via GATA2/MDM2/p53 axis, as demonstrated in Figure 4 ( Wu et al, 2021 ).…”

Section: Exosomal Microrna In Osteosarcomamentioning

confidence: 99%

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Exosomal MiRNAs in Osteosarcoma: Biogenesis and Biological Functions

Tang

Feng

et al. 2022

Front. Pharmacol.

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MiRNAs are a group of non-coding RNA molecules that function in mRNA translational inhibition via base-pairing with complementary sequences in target mRNA. In oncology, miRNAs have raised great attention due to their aberrant expression and pivotal roles in the pathogenesis of multiple malignancies including osteosarcoma. MiRNAs can be transported by exosome, the nano-extracellular vesicle with a diameter of 30–150 nm. Recently, a growing number of studies have demonstrated that exosomal miRNAs play a critical role in tumor initiation and progression, by exerting multiple biological functions including metastasis, angiogenesis, drug resistance and immunosuppression. In this review, we aim to depict the biogenesis of exosomal miRNAs and summarize the potential diagnostic and therapeutic functions of exosomal miRNAs in osteosarcoma.

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“…As such, MDM2 has been suggested as a promising target for cancer treatment [ 32 ]. For example, miR-15a suppresses the GATA2/MDM2 axis to inhibit the proliferation and invasiveness of osteosarcoma cells in vitro through the p53 signaling pathway [ 33 , 34 ]. In addition, the aberrant expression of MDM2 was linked to the development of BC [ 34–36 ].…”

Section: Introductionmentioning

confidence: 99%

CircMCTP2 (has-circ-0000658) facilitates the proliferation and metastasis of bladder carcinoma through modulating the miR-498/murine double minute-2 axis

Hou

Shi

et al. 2022

Bioengineered

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CircMCTP2 is a novel circRNA, which is associated with various kinds of malignant tumors progression, such as gastric cancer. However, the function of circMCTP2 in bladder carcinoma (BC) has no idea. The purpose of this study was tantamount to functionally dissect circMCTP2 in the progression of BC. In our study, circMCTP2 expression was strongly increased in BC tissues and cell lines. High expression of circMCTP2 predicted a poor prognosis of BC patients. CircMCTP2 deficiency impaired the cell growth, migration as well as invasive ability of BC cell lines (J82 and T24). In vivo , circMCTP2 deficiency cut the tumor growth rates and the tumor weight. In BC cells, circMCTP2 deficiency enhanced the translation of E-cadherin, while diminishing the translation of N-cadherin, Vimentin, and Snail. Moreover, circMCTP2 acted as a sponge of miR-498 to regulate murine double minute-2 (MDM2) expression. In BC tissues, a negative correlation was observed between the expression levels of circMCTP2 and miR-498. Additionally, either miR-498 silencing or MDM2 over-expression augmented the carcinogenic action of circMCTP2 on BC. In conclusion, our study showed that circMCTP2 regulates the expression of MDM2 by sponging miR-498 to promote the development of BC. These findings offer a new strategy for early diagnosis of BC and its therapeutics.

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Tumor suppressing role of serum-derived exosomal microRNA-15a in osteosarcoma cells through the GATA binding protein 2/murine double minute 2 axis and the p53 signaling pathway

Abstract: 2021): Tumor suppressing role of serum-derived exosomal microRNA-15a in osteosarcoma cells through the GATA binding protein 2/murine double minute 2 axis and the p53 signaling pathway, Bioengineered,

Cited by 13 publications

References 40 publications

Extracellular vesicles: A new diagnostic biomarker and targeted drug in osteosarcoma

Extracellular vesicles: A new diagnostic biomarker and targeted drug in osteosarcoma

Exosomal MiRNAs in Osteosarcoma: Biogenesis and Biological Functions

CircMCTP2 (has-circ-0000658) facilitates the proliferation and metastasis of bladder carcinoma through modulating the miR-498/murine double minute-2 axis

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