Tumor-Stroma Co-Cultures Modify the Invasive Properties of Human Pancreatic Adenocarcinoma Cells Through Different Patterns of Cytokine Secretion and Depending on the Type of Cell Lines.
Abstract:Background: Pancreatic ductal adenocarcinoma (PDAC) is among the most lethal cancer worldwide. One key feature of PDAC is a dense desmoplastic reaction that has become recognized to play important roles in tumor growth, metastasis, and therapeutic resistance. We aim to study tumor-stromal interactions in an in vitro co-culture model between human PDAC cells and fibroblasts.Methods: Capan-1 or PL-45 human pancreatic tumor cell lines and LC5 fibroblasts were grown in direct or indirect co-cultures, and their rel… Show more
Set email alert for when this publication receives citations?
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.