Tumor staging in a Beagle dog with concomitant large B-cell lymphoma and T-cell acute lymphoblastic leukemia

Abstract

An 8-y-old spayed female Beagle dog was presented with peripheral lymphadenomegaly. Lymph node cytology and flow cytometry led to the diagnosis of large B-cell lymphoma (LBCL). We detected minimal percentages of LBCL cells in peripheral blood and bone marrow samples. However, a monomorphic population of neoplastic cells different from those found in the lymph node was found in the bone marrow. T-cell acute lymphoblastic leukemia was suspected based on flow cytometric immunophenotyping. PCR for antigen receptor rearrangement (PARR) revealed clonal rearrangement of both B-cell and T-cell receptors, and the presence of both neoplastic clones in the lymph node, peripheral blood, and bone marrow. The dog was treated with multi-agent chemotherapy but died 46 d following diagnosis. Tumor staging and patient classification are needed to accurately establish a prognosis and select the most appropriate therapeutic protocol.

Cardiotoxicity associated with immune checkpoint inhibitors: Current status and future challenges

“…Some cells can promote whereas some can inhibit the occurrence and development of cardiovascular diseases (Figure 4). (Gisterå and Hansson, 2017;Tabas and Lichtman, 2017;Albany et al, 2019;Wu et al, 2019;Martini et al, 2020;Saigusa et al, 2020;Varricchi et al, 2020;Ferrari et al, 2021) Current treatment strategy for ICIrelated cardiotoxicity…”