2009
DOI: 10.1016/j.biomaterials.2009.01.058
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Tumor specificity and therapeutic efficacy of photosensitizer-encapsulated glycol chitosan-based nanoparticles in tumor-bearing mice

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Cited by 156 publications
(111 citation statements)
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“…Even simple PEGylation of the core photosensitizer itself results in high cellular uptake and low aggregation in biological media [121]. Similarly, protoporphyrin IX glycol-chitosan nanoparticles were shown to be superior to the non-encapsulated material [122].…”
Section: Biodegradable Nanoparticlesmentioning
confidence: 99%
“…Even simple PEGylation of the core photosensitizer itself results in high cellular uptake and low aggregation in biological media [121]. Similarly, protoporphyrin IX glycol-chitosan nanoparticles were shown to be superior to the non-encapsulated material [122].…”
Section: Biodegradable Nanoparticlesmentioning
confidence: 99%
“…Hydrophobically modified glycol chitosan derivatives can form stable self-aggregated nanoparticles in biological media solutions and be used as carriers for hydrophobic drugs and genes. [12][13][14][15] In our previous studies, cholesterol-modified glycol chitosan (CHGC) conjugate was synthesized and formed aggregated micelles in an aqueous medium. 16 In addition, the doxorubicin (DOX)-loaded CHGC nanoparticles exhibited prolonged circulation in the blood and showed higher antitumor efficacy against S180 tumorbearing mice through an enhanced permeability and retention effect than free DOX.…”
Section: Introductionmentioning
confidence: 99%
“…Biodegradable polymeric nanocarrier namely chitosan nanoparticles(CNPs) having an advantage of incorporating the hydrophobic drug PpIX to its hydrophobic inner core showed an improved tumor specificity and therapeutic efficiency for photodynamic therapy compared to free PpIX [17]. Studies on photosensitizers like PpIX, Rose Bengal (RB) with PAMAM and PPI dendrimers in HeLa cell lines, and with cyclic peptides in human cervical cancer SiHa cell line [18] are revealed to be non-toxic by PEGylation on their surface and also had good photodynamic activity both in vitro and in vivo [19].…”
Section: Introductionmentioning
confidence: 99%